Background & Objectives: Different studies have reported conflicting results on increased rate of early mortality after acute myocardial infarction (AMI) in females compared to males after adjustment for age and other confounding factors. The female gender plays a crucial role in early mortality after AMI. The aim of this study was to assess the role of gender as an important key factor in early mortality after acute myocardial infarction.

 Methods: In this research, patients (80 females and 174 males) with acute myocardial infarction were studies for six months (2003-2004) in terms of risk factors of coronary artery diseases, clinical conditions at admission, treatment modalities in the hospital and at the time of discharge, clinical accidents at the hospital and mortality and during one month after acute myocardial infarction and after being discharged.

 Results: Intrahospital mortality odds ratio for females compared to males was 2 (confidence interval 95%: 0.951-4.208). Mortality odds ratio during one month after acute myocardial infarction and discharge for females compared to males was 4.586 (confidence interval 95%: 1.294-16.252). This rate after adjustment for age was 3.15 (confidence interval 95%: 0.857-11.579) and after adjustment for confounders was 5.387 (confidence interval 95%: 1.296-22.393). In severe clinical conditions females referred to hospitals with more delay compared to men. Females were treated less than males with streptokinase, aspirin, betablockers and invasive diagnostic and treatment procedures. They received calcium channel blockers and nitrate much more than males.

 Conclusions : Females in comparison with males were at higher risk for early mortality (during one month after acute myocardial infarction and discharge). Age was not considered as the most important and potential factor for this higher rate.