1. Timar M, Banaei S. Protective effect of saponin on sperm DNA fragmentation of mice treated with cyclophosphamide. Andrologia. 2022;54(2):e14336. [DOI:10.1111/and.14336] [PMID]

2. Golmohammadi MG, Banaei S, Timar M, Abedi A. Saponin protects against cyclophosphamide-induced kidney and liver damage via antioxidant and anti-inflammatory actions. Physiol Int. 2023;110(2):108-120. [DOI:10.1556/2060.2023.00190] [PMID]

3. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330-8. [DOI:10.1038/nrc1074] [PMID]

4. Tanaka F, Fukuse T, Wada H, Fukushima M. The history, mechanism and clinical use of oral 5-fluorouracil derivative chemotherapeutic agents. Curr Pharm Biotechnol. 2000;1(2):137-64. [DOI:10.2174/1389201003378979] [PMID]

5. Chalabi-Dchar M, Fenouil T, Machon C, Vincent A, Catez F, Marcel V, et al. A novel view on an old drug, 5-fluorouracil: an unexpected RNA modifier with intriguing impact on cancer cell fate. NAR cancer. 2021;3(3):zcab032. [DOI:10.1093/narcan/zcab032] [PMID] []

6. Chibber S, Farhan M, Hassan I, Naseem I. White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study. Tumor Biol. 2011;32:881-92. [DOI:10.1007/s13277-011-0189-y] [PMID]

7. Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon Jr, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008;26(13):2131-8. [DOI:10.1200/JCO.2006.10.4182] [PMID]

8. Alter P, Herzum M, Soufi M, Schaefer J, Maisch B. Cardiotoxicity of 5-fluorouracil. Cardiovasc Hematol Agents Med Chem. 2006;4(1):1-5. [DOI:10.2174/187152506775268785] [PMID]

9. Kimura Y, Okuda H. Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5‐fluorouracil without loss of antitumor activity in mice. Jpn J Cancer Res. 1999;90(7):765-74. [DOI:10.1111/j.1349-7006.1999.tb00813.x] [PMID] []

10. Al‐Khrashi LA, Badr AM, AL‐Amin MA, Mahran YF. Thymol ameliorates 5‐fluorouracil‐induced intestinal mucositis: Evidence of down‐regulatory effect on TGF‐β/MAPK pathways through NF‐κB. J Biochem Mol Toxicol. 2022;36(1):e22932. [DOI:10.1002/jbt.22932] [PMID]

11. Noorbakhsh MF, Ahmadi N, Nazifi S, Nikravesh A-A, Hosseini Fard SE. The protective effects of silymarin in 5-fluorouracil-ınduced hepatotoxicity and nephrotoxicity in rats. Iran Vet J. 2022;18(3):103-13.

12. Safarpour S, Pirzadeh M, Ebrahimpour A, Shirafkan F, Madani F, Hosseini M, et al. Protective effect of kaempferol and its nanoparticles on 5-fluorouracil-induced cardiotoxicity in rats. Biomed Res Int. 2022:2273000. [DOI:10.1155/2022/2273000] [PMID] []

13. Safarpour S, Safarpour S, Moghadamnia AA, Kazemi S, Ebrahimpour A, Shirafkan F, et al. Cardioprotective effect of silymarin nanoemulsion on 5‐fluorouracil‐induced cardiotoxicity in rats. Arch Pharm (Weinheim). 2022;355(7):e2200060. [DOI:10.1002/ardp.202200060] [PMID]

14. Rishmawi S, Haddad F, Dokmak G, Karaman R. A Comprehensive Review on the Anti-Cancer Effects of Oleuropein. Life. 2022;12(8):1140. [DOI:10.3390/life12081140] [PMID] []

15. Romero-Márquez JM, Navarro-Hortal MD, Jiménez-Trigo V, Vera-Ramírez L, Forbes-Hernández TJ, Esteban-Munoz A, et al. An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative-and heat shock-stress responses in Caenorhabditis elegans. Food Chem Toxicol. 2022:162:112914. [DOI:10.1016/j.fct.2022.112914] [PMID]

16. Hadrich F, Mahmoudi A, Chamkha M, Isoda H, Sayadi S. Olive leaves extract and oleuropein improve insulin sensitivity in 3T3-L1 cells and in high-fat diet-treated rats via PI3K/AkT signaling pathway. Oxid Med Cell Longev. 2023:6828230. [DOI:10.1155/2023/6828230] [PMID] []

17. Menezes RCR, Peres KK, Costa-Valle MT, Faccioli LS, Dallegrave E, Garavaglia J, et al. Oral administration of oleuropein and olive leaf extract has cardioprotective effects in rodents: A systematic review. Rev Port Cardiol. 2022;41(2):167-175. [DOI:10.1016/j.repc.2021.05.011] [PMID]

18. Pojero F, Aiello A, Gervasi F, Caruso C, Ligotti ME, Calabrò A, et al. Effects of oleuropein and hydroxytyrosol on inflammatory mediators: Consequences on inflammaging. Int J Mol Sci. 2022 26;24(1):380. [DOI:10.3390/ijms24010380] [PMID] []

19. Geyikoglu F, Emir M, Colak S, Koc K, Turkez H, Bakir M, et al. Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury. J Food Drug Anal. 2017;25(2):447-459. [DOI:10.1016/j.jfda.2016.07.002] [PMID] []

20. Stringer JM, Swindells EO, Zerafa N, Liew SH, Hutt KJ. Multidose 5-fluorouracil is highly toxic to growing ovarian follicles in mice. Toxicol Sci. 2018;166(1):97-107. [DOI:10.1093/toxsci/kfy189] [PMID]

21. Naren G, Wang L, Zhang X, Cheng L, Yang S, Yang J, et al. The reversible reproductive toxicity of 5-fluorouracil in mice. Reprod Toxicol. 2021;101:1-8. [DOI:10.1016/j.reprotox.2021.02.002] [PMID]

22. Demir EA, Mentese A, Demir S, Kucuk H, Turkmen N, Aliyazicioglu Y. Evaluation of therapeutic effect of chrysin against 5-Fluorouracil-induced ovarian damage in rats. Farabi Tıp Dergisi .2023;2(1):1-7.

23. Taraborrelli S. Physiology, production and action of progesterone. Acta Obstet Gynecol Scand. 2015;94 Suppl 161:8-16. [DOI:10.1111/aogs.12771] [PMID]

24. Sinchak K, Wagner EJ. Estradiol signaling in the regulation of reproduction and energy balance. Front Neuroendocrinol. 2012;33(4):342-63. [DOI:10.1016/j.yfrne.2012.08.004] [PMID] []