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Showing 2 results for Zinc Sulfate
Parsa Yousefi, Abolhasan Faraz , Fatemeh Dorreh , Mahmoodreza Nakhaie , Zahra Moghaddasi, Sahar ,
Volume 10, Issue 2 (6-2010)
Abstract
Background and objectives: Common cold is the most common disease in children. Young children have an average of 6 to 7 colds each year. Some complications of common cold include: secondary bacterial infections, school absence and excessive cost for treatment. The management of the common cold consists primarily of symptomatic treatment. An effective and safe drug is needed to reduce the duration of common cold ۥ s symptoms in children and reduce subsequent complications. In some studies zinc sulfate has showed an antiviral effect and immune enhancing activity. Therefore this study designed to evaluate the efficacy of zinc sulfate in duration of cold ۥ s symptoms in children. Methods: This was a clinical trial study. The subjects were children between 1 - 7 years old with common cold that attended to pediatrics clinic of Arak Amir Kabir Hospital. The study included 112 patients randomized in two groups. One group received zinc sulfate within 10 days and other group didn’t receive this drug. Using a researcher made questionnaire duration of symptoms: rhinorhea and nasal obstruction, cough, sneezing, fever and duration of illness, in both groups were evaluated. Results: Consumption of zinc sulfate significantly reduced the mean duration of rhinorhea and nasal obstruction in children with common cold (p < 0.05). Also the mean duration of cough in zinc group was lower than the control group (p < 0.05). Compared to the group that didn’t receive zinc sulfate, the zinc group had shorter mean duration of sneezing (p < 0.05). Also the mean duration of fever in zinc group was shorter than the other group (p < 0.05). The mean duration of illness in patients who had received the zinc sulfate was significantly less than the other group (p <0.05). No side effect was observed in subjects received zinc sulfate. Conclusion: According to the results zinc sulfate can be administered with other supportive treatments of common cold, for reduction of symptoms duration and complications in children.
Nasim Karimzadeh Shushbolagh , Sepideh Mansour Kiaie , Kamaloddin Hamidi Nokhostin ,
Volume 23, Issue 1 (4-2023)
Abstract
Background & objectives: Zinc sulfate binds to the R group of some amino acids, such as histidine and cysteine, resulting in protein precipitation. In an ELISA and colorimetric experiments, we determined the optimal concentration of zinc sulfate to precipitate hemoglobin, which in turn affects the level and activity of Caspase 3 in red blood cells.
Methods: Osmotic stress was induced on red blood cells under hypertonic and hypotonic conditions. An isotonic condition was used as a control without osmotic stress. The cells were incubated at 37oC for 15 min and 24 hrs. Different concentrations of zinc sulfate were set up experimentally, stepwise after the lysis of RBC samples with ultrasound waves and removal of cell membranes by centrifugation. Zinc sulfate was allowed to bind to hemoglobin at different time intervals at room temperature. Afterward, hemoglobin was precipitated at various time intervals through centrifugation. The supernatants were then measured by ELISA and colorimetric methods for Caspase 3 level and activity.
Results: The optimal conditions were found to be 6 mM zinc sulfate, 10 min incubation at room temperature to bind zinc sulfate to hemoglobin, and 30 min centrifugation at 3000 rpm to precipitate hemoglobin.
Conclusion: This study showed that zinc sulfate with a concentration of 6 mM precipitates and removes hemoglobin without affecting the level or activity of Caspase 3.
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