|
|
|
 |
Search published articles |
 |
|
Showing 9 results for Zinc
Mohammad Mazani , Hasan Argani , Nadereh Rashtchizadeh , Mohammad Rohbaninoubar , Amir Ghorbanihagjo , Reza Mahdavi , Reza Razzaghi , Babak Rahimi Ardabily , Seyedjamal Ghaemmaghami ,
Volume 6, Issue 3 (9-2006)
Abstract
Background and Objectives: A great amount of evidence shows that Oxidative stress is high among hemodialysis patients. The purpose of present investigation is examination of the effect of zinc supplementation on improvement of oxidative stress in chronic hemodialysis patients. Methods: In this double blind clinical trial 65 chronic hemodialysis patients were studied in two groups Group one (35 patients) received placebo and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in next 2 months. Then, the study continued for two other months in the cross-over from. The levels of serum zinc, total glutathione, malondialdehyde (MDA), total serum antioxidant capacity and the activity of whole blood superoxide dismutase (SOD) were determined on 0th, 60th,120th,180th days, in fasting, predialysis samples. Food record was recorded for one day prior to dialysis in above-mentioned days and their dietary zinc was assessed. Results: Basal serum zinc levels in both groups were below 80 μ g/dl. The zinc upplementation led to significant increase in the levels of serum zinc in both groups .The levels of serum total antioxidant capacity, total glutathione and activity of whole blood SOD increased significantly during zinc supplementation period. The concentrations of serum MDA decreased significantly in zinc supplementation period in both groups. During the placebo period the levels of MDA in first group increased significantly, whereas the concentration of glutathione in second group decreased significantly. The body mass index (BMI) values did not change significantly during the study. Conclusion: It can be concluded that in patients undergoing hemodialysis the oxidative stress enhanced during nonsupplementation period (zinc sulfate). Low serum zinc levels are improved by zinc administration and zinc supplementation improves oxidative stress.
Nayereh Amini Sani , Manoochehr Barak , Seyedmorteza Shamshirgaran , Firooz Amani , Saadollah Mohammadi , Benyamin Fazli ,
Volume 7, Issue 2 (6-2007)
Abstract
Background & Objectives: The high incidence of low birth weight (LBW) occurs in developing countries, and diarrhea and respiratory infections are the main causes of infant mortality and morbidity. This study was done to find out whether there was a growth or morbidity response to zinc supplememttion, among LBW infants during the first 6 mo of life. Methods: The study was a randomized, placebo-controlled, and double-blind trial study. LBW infants were given daily for 6mo 5mg zn, or a placebo. Questionnairs were filled out during the study by a pediatrician and a GP. Anthropometric measurements were made at 0, 4, 8, 12, 16, 20 and 24 wk via home visits by trained interviewers. Results: Baseline characteristics were similar in zinc and placebo groups. Weight gain in zinc group was significantly higher that of placebo group between 1 to 6 months (p=0.036). Length and head circumference gain were also greater in zinc group than in placebo groups, (p=0.04, p<0.001). The episodes of upper respiratory infections was greater in placebo group than zinc group (mean Episodes in zinc groups= 1.7 and in placebo group was 3) and there was significant difference between two groups (p=0.005). 8 Cases of lower respiratory infections in placebo group and 5 cases in zinc group were observed, but it was not significan diarrheal episods were observed only in placebo groups. Conclusion: It was found that low birth weight infants had better growth and lower morbidity during the first 6 months of life by receiving zinc supplementation.
Mohammad Mazani , Hormoz Iremlou, Hasan Argani ,
Volume 10, Issue 2 (6-2010)
Abstract
Background and Objectives: Neuropathy is a common complication in hemodialysis patients. The purpose of this investigation is examination of the effect of zinc supplementation on nerve conduction velocity in chronic hemodialysis patients. Methods: In this clinical trial 65 chronic hemodialysis patients were studied in two groups: Group one (35 patients) received 100 mg placebo (corn starch) and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in the next 2 months. Then, the study continued for two other months in the cross-over form group one received 100 mg zinc and group two received 100 mg placebo daily for 2 months . The function of central and peripheral nerves were evaluated at the 0th, 60th, 120th, 180th days by nerve conduction velocity of electrodiagnostic test . Results: The function of nerves didn’t change significantly or some parameters markedly decreased in placebo period in both groups. Significant increase was found in the function of nerves during zinc supplementation period in both groups. Conclusion: These data indicate that zinc supplementation improve neuron function in patients undergoing hemodialysis
Parsa Yousefi, Abolhasan Faraz , Fatemeh Dorreh , Mahmoodreza Nakhaie , Zahra Moghaddasi, Sahar ,
Volume 10, Issue 2 (6-2010)
Abstract
Background and objectives: Common cold is the most common disease in children. Young children have an average of 6 to 7 colds each year. Some complications of common cold include: secondary bacterial infections, school absence and excessive cost for treatment. The management of the common cold consists primarily of symptomatic treatment. An effective and safe drug is needed to reduce the duration of common cold ۥ s symptoms in children and reduce subsequent complications. In some studies zinc sulfate has showed an antiviral effect and immune enhancing activity. Therefore this study designed to evaluate the efficacy of zinc sulfate in duration of cold ۥ s symptoms in children. Methods: This was a clinical trial study. The subjects were children between 1 - 7 years old with common cold that attended to pediatrics clinic of Arak Amir Kabir Hospital. The study included 112 patients randomized in two groups. One group received zinc sulfate within 10 days and other group didn’t receive this drug. Using a researcher made questionnaire duration of symptoms: rhinorhea and nasal obstruction, cough, sneezing, fever and duration of illness, in both groups were evaluated. Results: Consumption of zinc sulfate significantly reduced the mean duration of rhinorhea and nasal obstruction in children with common cold (p < 0.05). Also the mean duration of cough in zinc group was lower than the control group (p < 0.05). Compared to the group that didn’t receive zinc sulfate, the zinc group had shorter mean duration of sneezing (p < 0.05). Also the mean duration of fever in zinc group was shorter than the other group (p < 0.05). The mean duration of illness in patients who had received the zinc sulfate was significantly less than the other group (p <0.05). No side effect was observed in subjects received zinc sulfate. Conclusion: According to the results zinc sulfate can be administered with other supportive treatments of common cold, for reduction of symptoms duration and complications in children.
Robab Sheikhpour,
Volume 11, Issue 1 (4-2011)
Abstract
Background & objectives: Diabetes mellitus is a common metabolic disorder resulting from insulin deficiency or resistance. One of the most common problem in diabetic patients is atherosclerotic cardiovascular disease which induced by hyperlipidemia. Primary strategies for prevention of atherosclerotic cardiovascular disease are lowering of the lipids level by food and drugs. Zinc as an essential trace element may affect plasma lipid status . The aim of this study was to evaluate the effect of zinc on the levels of plasma lipids in patients with type II diabetes. Methods: In this clinical trial study, 60 diabetic patients were divided intwo groups. The first group received 25 mg/kg/day zinc and second group received 50 mg/kg/day zinc for 8 week. The levels of fasting serum lipids, lipoproteins and zinc were evaluated in each group before and after administration of zinc. SPSS software (V.11.5) and t-test were used for statistical analysis. Results: In the study procedure in each group 8 patients were excluded and 22 patients completed the study. There were not significant changes in the levels of zinc and serum lipids between before and after zinc treatment in the first group (25 mg/kg/day). The serum levels of zinc significantly increased after administration of 50 mg/kg/day zinc in the second group (160 ± 30 μg/dL vs 140 ± 30, p = 0.002). There also were significant changes in the levels of LDL-Cholesterol, total cholesterol before and after zinc supplementation in the second group (50 mg/kg/day). LDL significantly reduced after supplementation (123.9±33.53 vs 96.5±32.50, p=0.001), cholesterol reduced (226.68±31.40 vs 199.8 ±37.8 p=0.001), HbA1C reduced after zinc supplementation (9.7±1.86 vs8.9±1.5, p=0.02). Conclusion: It seems that Zinc at higher doses (50 mg/kg/day) is effective to decrease the levels of serum lipids and glycosylated hemoglobin in diabetic patients.
Reza Alipanahmogadam , Mohammad Mazani , Abbas Naghizadeh Baghi, Ali Nemati, Mojtaba Amani , Bahman Bashardoost, Amir Mansour Vatankhah , Shahab Bohlooli,
Volume 11, Issue 3 (9-2011)
Abstract
Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis . Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test. Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different. Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.
Afrouz Mardi, Mahnaz Azari , Manoochehr Barak , Mehrnaz Mashoufi , Parvaneh Naftchi , Nasrin Foladi ,
Volume 11, Issue 4 (12-2011)
Abstract
Background & Objectives: Diarrhea is one the important causes of mortality among children in developing countries. The effect of zinc supplementation in reduction the rate of diarrhea is controversial. The aim of this study was to evaluate the effect of zinc supplementation on the severity and duration of diarrhea in children less than 5 years old hospitalized in Ali-Asghar hospital in Ardabil, 2005. Methods: This study was a double-blind, randomized, placebo-controlled trial including 228 children with acute diarrhea. The subjects randomly assigned into two placebo and experimental groups (114 patients in each group). The placebo group received glucose (5%), while the experimental group received 20 mg/day Zn sulfate. The severity and duration of diarrhea were assessed during the study. Data were analyzed using Chi-square, Pearson correlation coefficient tests and Students t-test by SPSS software. Results: Our findings showed that most of the patients in both groups were male (age range 1-12 months, weight range 3-11 kg, weight percentile 3-50). These children had breast feeding and complete vaccination. They were the first baby in their family and the majority of them were from urban area (Ardabil city). The severity of diarrhea in zinc supplemented children (74.6%) was less than placebo group (89.5 % ) (p=0.037). There was no significant difference between two groups in the duration of diarrhea (p=0.737). There also was no relationship between the severity of diarrhea and weight percentile (p= 0.085). Conclusion: Our data indicate that zinc supplementation reduces the severity of acute diarrhea and could be advised in children with acute diarrhea.
Bahador Karimi, Zohreh Ghotbeddin, Seyed Reza Fatemi Tabatabaei ,
Volume 16, Issue 4 (1-2016)
Abstract
Background & objectives: Zinc as one of the most important trace elements is needed for proper functioning of the nervous system and homeostasis. Many studies show that stress causes memory impairment through various mechanisms, including oxidative stress induction and some mechanisms which are directly effecting brain function. So, in this work we assessed the effect of zinc chloride on passive avoidance memory and oxidative stress following acute stress in male rats.
Methods: In this study, 50 male Wistar rats were used in five groups: control, sham, stress, zinc chloride treatment and zinc chloride treatment before stress induction. For stress induction, rats were restrained (not immobilized) for 6 h/day, 7 days in a Plexiglas restrainer, and treated rats received an oral dose of zinc chloride 32 mg/kg/day by gavage for 6 days. At the end of the experiment, passive avoidance memory was avaluated by shuttle box and some oxidative damage markers were determined in all groups.
Results: Results of this study showed that animals which were exposed to stress showed a significant decrease in passive avoidance memory compared to control group (p<0.01) and the oxidative stress parameters in this group showed significant changes compared to the control group (p<0.05). While passive avoidance memory and oxidative stress parameters in group treated with zinc chloride were nearly closed to control group.
Conclusion: According to our results, zinc chloride with antioxidant properties can have a protective effect on memory impairment and oxidative stress induced by stress.
Nasim Karimzadeh Shushbolagh , Sepideh Mansour Kiaie , Kamaloddin Hamidi Nokhostin ,
Volume 23, Issue 1 (4-2023)
Abstract
Background & objectives: Zinc sulfate binds to the R group of some amino acids, such as histidine and cysteine, resulting in protein precipitation. In an ELISA and colorimetric experiments, we determined the optimal concentration of zinc sulfate to precipitate hemoglobin, which in turn affects the level and activity of Caspase 3 in red blood cells.
Methods: Osmotic stress was induced on red blood cells under hypertonic and hypotonic conditions. An isotonic condition was used as a control without osmotic stress. The cells were incubated at 37oC for 15 min and 24 hrs. Different concentrations of zinc sulfate were set up experimentally, stepwise after the lysis of RBC samples with ultrasound waves and removal of cell membranes by centrifugation. Zinc sulfate was allowed to bind to hemoglobin at different time intervals at room temperature. Afterward, hemoglobin was precipitated at various time intervals through centrifugation. The supernatants were then measured by ELISA and colorimetric methods for Caspase 3 level and activity.
Results: The optimal conditions were found to be 6 mM zinc sulfate, 10 min incubation at room temperature to bind zinc sulfate to hemoglobin, and 30 min centrifugation at 3000 rpm to precipitate hemoglobin.
Conclusion: This study showed that zinc sulfate with a concentration of 6 mM precipitates and removes hemoglobin without affecting the level or activity of Caspase 3.
|
|
.png)
.png)
