The OHS is characterized by hypersomnolence, hypoxia, polycytemia, headache and edema. Polysomnography is the gold standard diagnostic test. Overnight oximetry with significant oxyhemoglobin desaturation is reasonable to begin treatment. Weight reduction and Non invasive positive pressure ventilation (NIPPV) has evolved as the mainstay of treatment.

 Obesity is a risk factor for deep vein thrombosis (DVT). Heparin and warfarin are the drugs that used for treatment of DVT. HIT typically appears as a 50% or greater reduction in the platelet count after the first exposure to heparin. This case is a obese man with extreme DVT that diagnosed by duplex sonography and symptoms of obesity hypoventilation syndrom.

 In overnight pulseoximetry oxyhemoglobin desaturation was occurred more than 15 times per hours and treatment begins with NIPPV. Patients thrombosis were treated with heparin and warfarin. Heparin induced thrombocytopenia (HIT) and cutaneous necrosis was occurred and drug therapy withdrawn. After healing of cutaneous necrosis low dose warfarin was started.

 NIPPV promote airway occlusion and improve hypercapnia.hypoxia and quality of life and reduced cardiovascular complications.

  Background & objectives: Thrombocytopeniais, defined as a platelet count of less than 150,000/L complicates 7 to 10% of all pregnancies. Etiology of thrombocytopenia in pregnancy may include a ranging from benign disorders such as gestational thrombocytopenia to life threatening syndromes such as the HELLP (Hemolysis, Elevated liver Enzymes, Low Platelet count). The aim of this study was to evaluate frequency of thrombocytopenia in pregnancy among pregnantsrefered to Tonekabon health centers during 2009 .

  Methods: In a cross-sectional study, 150 normal pregnants bearing third trimester and refered to Tonekabon health centers were selected by random simple sampling. Patients´ demographic information and history were obtaied and CBC (complete blood count) test was done. Those pregnants suffered from thrombocytopenia were refered to a hematologist for compeleting tests if needed. Data analysis was done by SPSS 11.5 and chi-square test and p<0.05 was considered as signifcant difference .

  Results: The Prevalence of thrombocytopenia in pregnancy was 12.66% and the highest percent of thrombocytopenia (68%) was observed among nullipars. The cause of 95% of thrombocytopenia in pregnancy was gestational thrombocytopenia and 5% were due to ITP (Idiopathic Thrombocytopenia Purpura). The pregnants who suffered from gestational thrombocytopenia didn’t have any problems and no need to treatment but those who had been experienced ITP, used venous immunoglobin during labor for treatment .

  Conclusion: Gestational thrombocytopenia is the most common cause of the thrombocytopenia in pregnancy and isn’t dangerous for mother and fetus. So, it is no need to be done any intervention .