|
|
|
 |
Search published articles |
 |
|
Showing 3 results for Superoxide Dismutase
,
Volume 6, Issue 2 (6-2006)
Abstract
Background & Objectives: Diabetes mellitus may be associated with the imbalance between protective effect of antioxidants and increased free radical production with regard to discrepancies of the findings in previous researches the present study set out to determine the changes of plasma malondialdehyde and erythrocyte antioxidant superoxide dismutase activity in patients with type II diabetes mellitus. Methods: This case-control study was conducted in 2005 using random sampling. 38 patients with type II diabetes mellitus who referred to 5th Azar diabetes center and 19 age and sex matched healthy controls were selected for this study. Heparinated blood samples were taken from the cases. The separated plasma was tested for blood sugar, lipid peroxidation and blood cells (for glycolisated Hb and superoxide dismutase enzyme activity). The collected data were analyzed by SPSS (ver. 10) using t-test. Results: The level of plasma malondialdehyde from type II diabetes mellitus patients (6.27±0.80 nmol/ml) was significantly different from that in control group (3.56±0.98 nmol/ml)(p<0.05). Erythrocyte superoxide dismutase activity from type II diabetes mellitus patients (678.78±59.36 U/gr Hb) was significantly lower than control group (1056.47±52.98 U/gr Hb) (p<0.05). Conclusion: The significant difference between the increase in malondialdehyde and decrease in the activity of antioxidant enzymes in patients with type II diabetes mellitus may predispose to the development of serious complications leading to cellular damage. This suggest that diabetic patients may need more antioxidants than normal. Supplementation with medical or non-medical free radical scavengers such as vitamins E and C or foods untaining vitamin C (sitrus fruits) have a potential role in reinforcing antioxidant defence and can be important in diabetic patients.
Reza Alipanahmogadam , Mohammad Mazani , Abbas Naghizadeh Baghi, Ali Nemati, Mojtaba Amani , Bahman Bashardoost, Amir Mansour Vatankhah , Shahab Bohlooli,
Volume 11, Issue 3 (9-2011)
Abstract
Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis . Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test. Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different. Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.
Farid Manafi , Reza Alipanah-Moghadam , Ali Nemati, Vadood Malekzadeh, ,
Volume 17, Issue 4 (1-2017)
Abstract
Background & objectives: Andrographolide has potent antioxidant properties. There is still not a complete understanding of the antioxidant effects of andrographolide. In this study, the effect of andrographolide on the serum antioxidant activity of superoxide dismutase and catalase was investigated in the rats with secondary iron overload.
Methods: In this experimental study, 32 rats were divided into 4 groups of 8 each. The groups included: 1-Control 2- Receiving iron 3- Receiving iron treated with 7 mg/kg andrographolide 4- Receiving 7 mg/kg andrographolide. The serum activity of superoxide dismutase and catalase and serum level of malondialdehyde (MDA) was measured using colorimetric method. Prussian blue was used to evaluate iron deposition in liver.
Results: The results showed that iron was deposited in the liver. The activity of superoxide dismutase and catalase in the secondary iron receiving group, compared to control group, was significantly increased (p<0.05). The activity of catalase was significantly decreased in the group receiving iron and treated with andrographolide, compared to the control and iron receiving groups (p<0.05). Also, the activity of superoxide dismutase in the group receiving iron and treated with andrographolide decreased significantly compared to the iron receiving group (p<0.05). Serum levels of malondialdehyde in the iron receiving group were higher than the control group (p<0.05). Serum levels of malondialdehyde in the group receiving iron and treated with andrographolide, compared with the iron receiving group, showed a significant decrease (p<0.05).
Conclusion: Andrographolide (7mg/kg) reduced the serum activity of catalase and superoxide dismutase and malondialdehyde serum levels in rats with secondary iron overload.
|
|
.png)
.png)
