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Showing 25 results for Stress
Ahmad Hashemzadeh, Farhad Heidarian,
Volume 5, Issue 2 (6-2005)
Abstract
Background & Objectives: Respiratory distress is one of the most important causes of children admission in hospitals. In most cases, it is due to pneumonia, asthma or acute bronchiolitis. Since theses diseases have a lot of symptoms in common, we decided to study these disorders in more details to facilitate the appropriate diagnosis and treatment based on clinical, laboratory and radiologic findings. Methods: 238 children who suffered from respiratory distress and were admitted to pediatric ward in Ghaem hospital were studied. This descriptive study was performed during 3 years including 2 retrospective and one prospective year. The relationship between variables was analyzed using chi-square test. Results: The patients were six months to five years old. Pneumonia (40.3%) asthma (30.3%) and bronchiolotis (16.8%) were the most common causes of respiratory distress. Totally, 61.1% of the patients were male. The mean age of the patients was 10.3 months in bronchiolitis and 36.6 months for asthma. The most common symptom among these three diseases was tachypnea. Most of the patients were admitted in winter and fall respectively. The main radiologic pattern in pneumonia was pulmonary infiltration and for asthma and acute bronchiolitis it was pulmonary hyperinflation. Conclusion: Proper attention to signs and symptoms as well as laboratory and radiologic fndings is necessary for accurate diagnosis. In this study the most common cause of respiratory distress in children under 5 was found to be pneumonia, asthma and bronchiolitis respectively.
Mohammad Narimani , Yoosof Khonya , Abbas Abolghasemi , Masoud Ganji , Gafar Majidi ,
Volume 6, Issue 2 (6-2006)
Abstract
Background & Objectives: Clinical findings show that stress can gradually affect the activity of various systems of the body such as immune system and impair them. Different variables potentiate and modify this effect. This research aimed at studying the relationship of personality traits (self-respect, tenacity, type A personality), stress, and stress coping skills with immune system status in nurses. Methods: In this descriptive-analytical study, 246 individuals were selected by simple random sampling method. At the first stage, the subjects on the job completed the questionnaires of self-respect, tenacity, type A personality, stress, and stress coping skills. At the second stage to determine the amount of antibodies, 2-cc blood of the subjects was assessed. The data were analyzed using correlational methods. Results: The findings indicated a significant, positive and meaningful relationship of immunoglobulin antibody with “self-respect”, and IgM antibody with “type A personality” in male nurses (p<0.05). But there was no significant relationship between the immune system variables and tenacity, stress, and stress coping skills. From among the predictive variables (self-respect, tenacity, type A personality, stress, and stress coping skills) only the stress variable had significant relationship with the criterion variable (IgA antibody)(p=0.05). Conclusion: Regarding the results it can be said that self-respect may adjust IgG variable in stress positions (especially in chronic stress). So in hard jobs such as nursing, psychological characteristics should be considered as an important job factor along with physical capabilities.
Mohammad Mazani , Hasan Argani , Nadereh Rashtchizadeh , Mohammad Rohbaninoubar , Amir Ghorbanihagjo , Reza Mahdavi , Reza Razzaghi , Babak Rahimi Ardabily , Seyedjamal Ghaemmaghami ,
Volume 6, Issue 3 (9-2006)
Abstract
Background and Objectives: A great amount of evidence shows that Oxidative stress is high among hemodialysis patients. The purpose of present investigation is examination of the effect of zinc supplementation on improvement of oxidative stress in chronic hemodialysis patients. Methods: In this double blind clinical trial 65 chronic hemodialysis patients were studied in two groups Group one (35 patients) received placebo and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in next 2 months. Then, the study continued for two other months in the cross-over from. The levels of serum zinc, total glutathione, malondialdehyde (MDA), total serum antioxidant capacity and the activity of whole blood superoxide dismutase (SOD) were determined on 0th, 60th,120th,180th days, in fasting, predialysis samples. Food record was recorded for one day prior to dialysis in above-mentioned days and their dietary zinc was assessed. Results: Basal serum zinc levels in both groups were below 80 μ g/dl. The zinc upplementation led to significant increase in the levels of serum zinc in both groups .The levels of serum total antioxidant capacity, total glutathione and activity of whole blood SOD increased significantly during zinc supplementation period. The concentrations of serum MDA decreased significantly in zinc supplementation period in both groups. During the placebo period the levels of MDA in first group increased significantly, whereas the concentration of glutathione in second group decreased significantly. The body mass index (BMI) values did not change significantly during the study. Conclusion: It can be concluded that in patients undergoing hemodialysis the oxidative stress enhanced during nonsupplementation period (zinc sulfate). Low serum zinc levels are improved by zinc administration and zinc supplementation improves oxidative stress.
Ferdos Ghomashchi,
Volume 8, Issue 3 (9-2008)
Abstract
Background & Objectives: Serious reactions which normally is delayed and occur against serious stressor factors like natural disasters (for example: earth quake, flood and etc) and human made disasters (for example war, murder and etc) calls post traumatic stress disorder (PTSD). The aim of this study was Assessing the effectiveness of teaching problem solving skills in decreasing the symptoms of PTSD. Methods:The type of this research is experimental. After clinical assessment and selecting with clinical assessment these individuals showed PTSD symptoms through the results of both Mississippi scale and clinical appointment, in which there were 160 cases. The cases were separated to two groups of experimental and control. Through an experimental method, we studied and measured changes of their status before and after examination and only case group had been chosen for problem solving skills teaching. In order to analyze the results of the study, a T test and Variance analysis (ANOVA) were used. Results: The results showed that 61.6 percent of population showed PTSD symptoms and there was no significant difference between male and female in level of PTSD symptoms. There was a significant difference between, means level of PTSD in pre-test and post-test conditions, in addition there was no significant difference between levels of PTSD symptoms-decreasing, in female group after intervention, and male group. By comparing mean numbers of samples, in pre-test and post-test results of control and experiment groups in using problem-focused coping skills and decreasing emotion-focused coping skills, there was a significant differences. Also there was not any difference in using levels of coping methods, but indeed in amount of using emotion-focused coping method there was significant difference between male and female. Conclusion: Presence of significant differences between pre-test and post-test results showed that training problem-solving-skills in decreasing PTSD symptoms is effective.
Saeid Nafisi , Seyed Shamsaddin Athari , Reza Kazemi , Ehsan Hosseini ,
Volume 9, Issue 4 (12-2009)
Abstract
Background and objectives: During the last years the effects of pulsative electromagnetic fields have been studied in the human and animals nervous system. The using of these fields in today living has caused worriment in safety of human. Stress causes very problems in behavior and function of biological systems. In this survey the effects of electromagnetic fields on stress behaviors of rats have been studied. Methods: In this study we aimed to investigate the effects of electromagnetic fields with 700 milli Gauss currency produced by triangle electrical currents with low (10 Hz) and high (110 kHz) frequencies on stress behaviors in 60 adult, male Wistar rats. The rats were divided to two groups of control and test. The animals were exposed to the field for 80 minutes and in order to evaluate the possible effect of electromagnetic fields the Tail pinch (T.P.) test was conducted. The results were analyzed using statistical tests. Results: Analyzing of the results of response time and stress behavior by T-test. In the group exposed electromagnetic fields of triangular low waves (10 Hz) for 80 min the results were meaningful (p < 0.05). The response and stressed behavior with this field is decreased very much. The results of two groups after 80 min under this field that have a difference in frequency showed that effects of frequency in behavior was meaningless. Conclusion: The results of this study showed that electromagnetic fields produce anti-stress effect in rats. The radio waves (A.W) have higher effects.
Behnam Molaie , Mohammadali Mohamadi , Aghil Habibi , Vahid Zamanzadeh , Behrouz Dadkhah , Parviz Molavi, Naser Mozaffari ,
Volume 11, Issue 1 (4-2011)
Abstract
Background and Objectives: The importance of considering to job stress among women is not related to loss of economics alone, but it makes an unsafe condition in health of body and soul of person, family and society, too. This study was aimed to determine the rate of job stress among employed women in Ardebil during 2010. Methods: In a descriptive cross-sectional study, 1250 governmental-employed women were selected in different offices of Ardabil city. Data were collected by job-contained Karasek questionnaire and results were analyzed by chi-square test. Results: The results showed that 62.8% of women experienced medium level of stress and 36.5% revealed to have severe stress. Our findings significantly showed that there are relationship between stress rate of individuals with number of children, level of education, place of living, job experience, rate of work hours per day and night work shift, employment status, physical and mental diseases (p <0.05 ( . Conclusion: With respect to severe stress found in employed women in study setting, it seems to need to increase mental health indices in individuals, families and community, and the authorities should develop a comprehensive plan to enhance productivity and satisfaction among employees.
Reza Mahdavi , Ali Nemati , Eiraj Feizi, Mojtaba Amani , Hosein Alimohammadi Asl, Mohammad Mazani M, Phd4; Nagizadeh Bagi , Abbas , Ali Shadman , Reza Alipanah Mogadam, Asghar Pirzadeh, Mousa Ghayour Nahand,
Volume 11, Issue 2 (6-2011)
Abstract
Background & Objectives: Consumption of ω3 fatty acids supplementation inhibits oxidative stress injury, increases activity of antioxidant enzymes and decreases lipid peroxidation in gastric cancer patients. In this study, we examined effects of ω-3 fatty acid intakes on oxidative stress in gastric cancer patients undergoing chemotherapy. Methods: This double blind clinical trial study was conducted on 30 adult patients (15 cases and 15 controls) with gastric cancer during chemotherapy in Ardabil city in 2010. Case and control groups were selected by randomized allocation. Three grams ω -3 fatty acid supplementation (1.8 g EPA & 1.2 g DHA in 10 g fish oil) and placebo were given case and control groups for 45 days, respectively. Anthropometric indices (weight, height & BMI) were measured. Blood samples were taken and then biochemical factors including triglycerides, total cholesterol, HDL and LDL cholesterol, MDA, and total antioxidants were evaluated at the beginning, middle and end of the study . The data were analyzed by using Paired sample t-test, Independent sample t-test and repeated measures test. Results: MDA, Weight and BMI of omega group after intervention were significantly more than control group at the end of the study (p<0.05). Weight and BMI were decreased but serum MDA was significantly increased in control group during the study (p<0.05). Weight, BMI , and total antioxidants were significantly increased in omega group during day 30-45, (p<0.05). There were no significant differences in other biochemical factors at the end of study. Conclusion: The present investigation shows administration of ω3 fatty acid supplements to gastric cancer patients during chemotherapy increases the total antioxidants capacity and prevents the enhancement of oxidative stress.
Reza Alipanahmogadam , Mohammad Mazani , Abbas Naghizadeh Baghi, Ali Nemati, Mojtaba Amani , Bahman Bashardoost, Amir Mansour Vatankhah , Shahab Bohlooli,
Volume 11, Issue 3 (9-2011)
Abstract
Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis . Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test. Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different. Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.
Maryam Ghasemi , Farzad Rajaei, Darioush Mohammadnejad, Amir Javadi,
Volume 11, Issue 4 (12-2011)
Abstract
Background & Objectives: Stress in developing countries is an important problem in human health. Feelings of stress in humans result from interactions between persons and their environment. Stressor is an external stimulus or an event that provokes a stress response in an organism. Animal models enable preclinical testing of new treatments and therapies for physical symptoms of stress disorder. In the present study the effects of social stress on male mouse reproductive system were investigated. Methods: Sixty male mice were divided into 6 groups, including two non-stressed control groups (2 cages, 5 mice per cage), two mild-stressed groups (2 cages, 10 mice per cage), and two high-stressed groups (2 cages, 15 mice per cage). Three cages (one cage from each group) kept for one month and three cages kept for two months. After one and two months the mice were anaesthetized with ketamine and xylazine. Tissue samples of testes , epididymis and vas deferens for light microscopy were removed . Data analysis was performed using one-way ANOVA. P<0.05 was considered significant. Results: The results showed that there was no significant difference between mild and high-stresses groups in the diameter of seminiferous tubules, vas deferens, height of epithelial cells of epididymis and vas deferens. The diameter of epididymis in mild and high-stressed groups was significantly decreased as compared with that in non-stressed control groups (P<0.02, P<0.009). The diameter of vas deferens in mild-stressed groups was significantly decreased as compared with in non-stressed control groups (P<0.02). The height of epithelial cells of vas deferens in mild and high-stressed groups was significantly decreased as compared with that in non-stressed control groups (P<0.001, P<0.001). Conclusion: This study shows that crowding stress can decrease the diameter and height of epithelial cells of epididymis and vas deferens of male mice .
Sara Rahbar, Naser Ahmadiasl,
Volume 12, Issue 3 (9-2012)
Abstract
Background & Objectives: Numerous studies have been conducted to assess the effects of acute resistance exercises on the structure and the function of heart, but little works done on effects of chronic resistance exercises. So, the objective of current study was to investigate the long term effect of regular exercises on cardiac function and oxidative stress. Methods: Forty male Wistar rats in the weight range of 250- 300 g were used in this study. They were divided in 2 following groups: The 3 months exercises test group and control group which remained without exercises. Regular resistive exercise was carried out according to the model proposed by Tamaki et al. Test group rats exercised for three months. Finally the hearts of 10 rats in each group were taken for homogenization, oxidative stress measurement and the other ten were examined for heart function. Malondialdhyde as an index of oxidative stress and superoxide dismutase, glutathione peroxides and catalase as an indicator of antioxidant capacity with special kits were specifically measured. Results: Regular resistive exercise didn't significantly affect the rats' weight, but heart weight in exercise group showed a significant increase (p<0.05). There was a significant decrease in heart rate in exercise group (p<0.05). Left ventricle contraction strength and coronary flow had a significant increase in exercise group in comparison with control group (p<0.05). There was not any significant difference in Malondialdhyde and antioxidant enzymes activity. Conclusion: This study showed that, heart efficiency had a significant improvement under effect of regular resistive exercise. Meanwhile, regular resistive exercise didn’t have any significant effect on oxidative stress and heart antioxidant defense capacity.
Ali Shadmanfard, Ali Nemati , Abbas Naghizadeh Baghi, Mohammad Mazani,
Volume 12, Issue 5 (11-2012)
Abstract
Background & Objectives: The intake of antioxidant supplementations can have key role in prevention of oxidative stress in healthy individuals. Pomegranate has antioxidant effects and may play a role in reduction of oxidative stress in healthy males. Therefore, this study examined the effect of pomegranate juice supplementation on oxidative stress in young healthy males. Methods : In semi-experimental study, 14 healthy students living in Dormitories of Ardabil University of Medical Sciences were included. Subjects were given one cup of pomegranate juice supplementation per day for two weeks . Fasting blood samples were taken both at the start and the end of 2-week period to measure the antioxidant enzyme activities such as superoxide dismutase , glutathione peroxidase , paraoxonase - 1, aryl esterase , and the values of serum total antioxidant capacity , glutathione, and lipid profiles . Data were analyzed using descriptive and paired t - test s. Results: T he level of serum total antioxidant capacity and activities of enzymes such as superoxide dismutase, glutathione peroxidase, arylesterase, and standardized arylesterase activity were significantly increased at the end of two weeks (p<0.05). The serum level of malondialdehyde was significantly decreased after intervention (p<0.05). Changes were not significant, although the serum levels of glutathione and HDL- cholesterol increased and LDL- cholesterol decreased at the end of two weeks period. Conclusion: The results of this study showed that the pomegranate juice supplementation had beneficial effects in helping body's antioxidant defense system and reduction of oxidative stress in young healthy males . This study suggests that the pomegranate juice supplementation can be useful against oxidative stress included in dietaries of young healthy males.
Mostafa Nachvak , Sheida Ahani Kamangar , Ali Nemati , Saeid Sadeghieh Ahari ,
Volume 14, Issue 2 (7-2014)
Abstract
Background & Objectives: Epidemiological and experimental evidences suggest that oxidative stress is elevated in children with Down syndrome (DS). Some studies show that consumption of diets with a high content of fruits and vegetables results in a significant reduction in markers of oxidative stress. We investigated the frequency of fruits and vegetables intake in children with DS and the influence of variations in the level of this consumption on biomarkers of oxidative stress . Methods: Frequency of consumption of fruit and vegetables by children with DS were recorded by interview with the children’s parents. Serum malondialdehyde (MDA) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) were also measured as biomarkers of oxidative stress. Data analysed using ANOVA and Student’s t-tests . Results : Mean consumption of fruits and vegetables was 4.6 and 0.74 servings per week, respectively. No significant relationships were found between consumption of fruits and vegetables with markers of oxidative stress. Based on our findings, the 65.9 % of the children did not eat any vegetables and the rest of the children consumed less than one serving per day. There was a significant correlation between the frequency of fruits and vegetable consumption (r=0.212 p <0.04). Conclusion : There wasn’t any significant relationship between fruits and vegetables consumption and indicators of oxidative stress in children with DS. This lack of correlation could be due to low consumption of fruits and vegetables in children with DS.
Mojghan Mirghafourvand , Fahimeh Sehhatieshafaie , Jaleh Vosoughi-Niri ,
Volume 14, Issue 4 (1-2014)
Abstract
Background & objectives: Childbirth is the most stressful event for the women both mentally and physically affecting their physiological and psychological indicators during labour. The aim of this study was to assess the effect of non-pharmacological methods of labor pain relief in mothers’ perceived stress conducted in Alavi hospital of Ardabil, 2013. Methods: In this double blind randomized controlled trial, 320 mothers were allocated into two groups by stratified block randomization . The intervention group (n=158) received continuous support throughout the labour process, positioning and movement, music, aromatherapy, showering andconsumption of a light diet or water.The control group received only a routine care. The perceived stress scale (PSS) was employed to collect data in three stages at the beginning of the active phase, before the intervention, six hours after birth and then eight weeks postpartum. The two groupswere compared using General Linear Model with controlling the baseline scores. Results: There were 14 participants loss to follow-up. The mean of perceived stress score in the intervention group was significantly lower than the control group at 6 hours [adjusted mean difference: -1.0 (95% confidence interval: -0.01 to -1.9]. However, there was no difference between two groups in terms of perceived stress score at 8 weeks postpartum (p=0.692). Conclusion: Non-pharmacological methods of labor pain relief are an effective intervention for reducing perceived stress level in mothers during labor and therefore use of this intervention is recommended.
Farnaz Seifi-Skishahr, Arsalan Damirchi , Manoochehr Farjaminezhad , Parvin Babaei ,
Volume 15, Issue 1 (4-2015)
Abstract
Background & objectives: The “redox” state represents the oxidation/reduction potential within the cell in a way that more “redox” is the marker of health, while the more oxidized reflects predisposition to diseases. Different types of exercise training may change the thiol/disulfide ratio of redox couples such as glutathione and represent a shift in redox balance. This study was assessed the influence of high-intensity aerobic exercise on glutathione redox state in red blood cells in professional, recreational athletes and nonathletes.
Methods: Ten voluntary well trained (WT), moderately trained (MT) and untrained men subjectswere randomly selected for this semi-experimental study (mean ages of 21.10±1.72 21.70±1.88 and 20.10±1.44, respectively). Blood samples were collected before, immediately, 10 min and 30 min after acute aerobic exercise with 75%VO2max. The levels of reduced glutathione (GSH), oxidized glutathione (GSSG) and (GSH/GSSG) in red blood cells (RBCs) as well as serum levels of cortisol and creatine kinase (CK) were measured.
Results: The results showed reduction, elevation and no changes in RBCs GSH/GSSG ratio in UT, MT and WT groups, respectively. The lowest levels of GSH/GSSG ratio in RBCs and the highest one were detected in the WT and MT groups, respectively. The serum levels of cortisol and creatine kinase were increased following the exercise in three groups.
Conclusion: It is concluded that acute aerobic exercise with high intensity does not change redox balance in well trained subjects, however it is capable to shift redox balance towards more reducing environment in moderately trained subjects and also to more oxidizing one in untrained subjects.
K Tahmasebi, M Jafari, F Izadi,
Volume 15, Issue 2 (7-2015)
Abstract
Background & objectives: Diazinon (DZN) as an organophosphate pesticide widely used in agriculture is associated with reducing the antioxidant capacity of the cell. Use of thiol compounds such as N-acetyl cysteine (NAC) as an antioxidant decreases oxidative stress in the cells. The aim of this study was to investigate the effect of NAC as an antioxidant against DZN- induced oxidative stress in rat brain and heart.
Methods: In present experimental study, male Wistar rats were randomly divided into four groups including: control group (corn oil as DZN solvent), DZN group (100 mg/kg), NAC group (160 mg/kg), and NAC+DZN, all of which were given intraperitoneally. 24 hours after injection, animals were anesthetized by ether, and the brain and heart tissues were quickly removed. After tissues hemogenation, superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and lactate dehydrogenase (LDH) activities, as well as glutathione (GSH) and malondialdehyde (MDA) levels were determined by biochemical methods.
Results: DZN increased SOD and GST activities and MDA level and decreased LDH activity and GSH content in brain and heart. Also, DZN increased CAT activity in the heart and increased it in the brain. Administration of NAC inhibited the change in these parameters.
Conclusion: DZN through free radical production leads to enhanced membrane lipid peroxidation, depleted GSH content and oxidative stress induction in the brain and the heart. Administration of NAC as antioxidant decreases the DZN-induced oxidative stress by scavenging free radicals and GSH synthesis, but its protection is not complete.
Amir Azizi , Javad Mohamadi ,
Volume 16, Issue 1 (4-2016)
Abstract
Background & objectives: Depression and perceived stress are considered among the most common symptoms of irritable bowel syndrome. Dialectical behavior therapy was presented as one of the most effective treatment of many disorders in the past decade. Therefore, the purpose of this study was to determine the effectiveness of dialectical group behavior therapy on perceived stress and depression in patients with the irritable bowel syndrome.
Methods: The research method was an experimental pretest-posttest control group design with random assignment). Of all the patients referred to medical centers in Tabriz during 1393 SH, 30 patients selected with irritable bowel syndrome and Rome-III diagnostic criteria after using the interview, completed perceived stress questionnaire and the Beck Depression Inventory. The subjects were selected and randomly assigned to experimental and control groups (n=15 per group). After completing dialectical behavior therapy in the experimental group, the questionnaire was administered in both groups. Data were analyzed using multivariate analysis with SPSS-20 software.
Results: Dialectical group behavior therapy was significantly effective in reducing perceived stress (p= 0.004, F= 9.91) and depression (p= 0.005, F= 9.60) in patients with irritable bowel syndrome in experimental group, so that after the intervention the perceived stress and depression scores decreased in experimental group.
Conclusion: It seems that dialectical behavior therapy is effective in reducing perceived stress and depression in patients suffering from irritable bowel syndrome and can be helpful in improving the symptoms of perceived stress and depression in these patients.
Bahador Karimi, Zohreh Ghotbeddin, Seyed Reza Fatemi Tabatabaei ,
Volume 16, Issue 4 (1-2016)
Abstract
Background & objectives: Zinc as one of the most important trace elements is needed for proper functioning of the nervous system and homeostasis. Many studies show that stress causes memory impairment through various mechanisms, including oxidative stress induction and some mechanisms which are directly effecting brain function. So, in this work we assessed the effect of zinc chloride on passive avoidance memory and oxidative stress following acute stress in male rats.
Methods: In this study, 50 male Wistar rats were used in five groups: control, sham, stress, zinc chloride treatment and zinc chloride treatment before stress induction. For stress induction, rats were restrained (not immobilized) for 6 h/day, 7 days in a Plexiglas restrainer, and treated rats received an oral dose of zinc chloride 32 mg/kg/day by gavage for 6 days. At the end of the experiment, passive avoidance memory was avaluated by shuttle box and some oxidative damage markers were determined in all groups.
Results: Results of this study showed that animals which were exposed to stress showed a significant decrease in passive avoidance memory compared to control group (p<0.01) and the oxidative stress parameters in this group showed significant changes compared to the control group (p<0.05). While passive avoidance memory and oxidative stress parameters in group treated with zinc chloride were nearly closed to control group.
Conclusion: According to our results, zinc chloride with antioxidant properties can have a protective effect on memory impairment and oxidative stress induced by stress.
Faranak Hasanpour, Kamaleddin , Hamidi , Saber Zahri, Saeeid Latifi Navid ,
Volume 17, Issue 2 (7-2017)
Abstract
Background & Objectives: Breast cancer is one of the most common cancers of women in the world. Apoptotic pathway is one of the most important pathways to deal with cell damage, especially cancer, which is usually blocked in this disease. One of the main enzymes to set up this pathway is JNK (1,2,3α,3β), which is activated by cellular stress.
Methods: In this study, breast cancer cells with the origin of MCF-7 cell lines were cultured in RPMI medium using 10%fetal bovine serum.Then , they were subjected to heat (42 & 45 ̊ C) for 1,2,4,6 and 8 hours under X-ray and γ-ray radiations for 1,2,3 and 4 hours as well. Their viability and enzyme level were evaluated by MTT and ELISA tests, respectively.
Results: The obtained results showed that abiotic stresses including heat and radiations resulted in JNK level increase and recovery of apoptosis pathway function in breast cancer cells. In addition, they led to decreased of cell viability and increase of JNK level depending on the duration and kind of stress.
Conclusion: The results in this study showed abiotic stress directly affected the JNK level. Increase of this enzyme in the cell resulted in activity of JNK apoptosis pathway. We hope to find methods to help to cancer treatment by means of more studies on JNK enzyme and relevant pathways.
Keyvan Amirshahrokhi , Shahab Bohlooli , Mohammad Yousefi ,
Volume 18, Issue 3 (10-2018)
Abstract
Background & objectives: The purpose of this study was to show the dose response relationship of anti-inflammatory effect of methylsulfonylmethane (MSM) on carrageenan induced rat paw edema as an acute model of inflammation.
Methods: A total of 54 male, Sprague-Dawley rats, weighing 180-190 g, were used. One hundred, 200, 400, 800 and 1200 mg/kg of MSM were administered intraperitoneally to the rats 30 minutes before induction of paw edema with injection of 0.1% carrageenan. Diclofenac was used as a control drug. Rats were divided into three groups: MSM, diclofenac and normal saline, and their paw tissue were collected for the study of inflammatory and oxidative markers (MDA, GSH, TNF-α and IL-1 β). The relationship between the different concentrations of MSM and decrease in rat paw edema was calculated using a simple Emax model.
Results: the ED50 value for effect of MSM on carrageenan induced rat paw edema was 193±9.7 mg/kg. A significant reduction in paw edema following administration of MSM at 200, 400, 800 and 1200 mg/kg was observed, but statistical analysis did not reveal any significant reduction in paw edema after administration of 100 mg/kg. MSM did not show statistically significant difference from control group in tissue level of GSH, but it was able to decrease MDA level significantly. MSM was able to significantly alleviate IL-1 β and TNF-alpha tissue levels.
Conclusion: The recommended anti-inflammatory dosing range of MSM is 200-800 mg/kg for pharmacological studies in rats and the average appropriate dose is 400 mg/kg. Also, it seems that anti-inflammatory effect of MSM is more profound than its anti-oxidant effects.
Sara Taghizadeh , Alireza Moradian, Mohammad Narimani ,
Volume 19, Issue 1 (4-2019)
Abstract
Background & objectives: Chronic illnesses are one of the most important causes of mortality. The purpose of this study was to investigate the relationship between perfectionism and stress with life satisfaction in cardiovascular patients.
Methods: The research method is descriptive correlational. The statistical population of this study included patients who came to receive the services in Ardabil in the first half of 1396. The sample consisted of 60 cardiovascular patients who were selected by simple random sampling. Data was collected using questionnaires of perfectionism scale, stress scale and life satisfaction scale. Data were analyzed by descriptive statistics and multiple regression analysis using spss-19 software.
Results: The results showed that there is a significant negative relationship between perfectionism and life satisfaction. Also, there was a significant negative relationship between stress and life Satisfaction (p<0.01). In other words, with increasing stress, life satisfaction decreases. There is a multiplicity relationship between perfectionism and stress with life satisfaction (p<0.01).
Conclusion: The results of this study showed that reducing the perfectionism and stress of individuals helps to increase the satisfaction of people from life and also effective in the process of treatment.
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