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Showing 2 results for Spinal Cord Injury
Ali Niapour, Zahra Taghipour, Sahar Kiani, Fereshteh Karamali, Nazila Niapour, Mohammad Mehdi Mir Hosseini, Mohammad Reza Piri, Hosein Salehi, Noruz Najafzadeh, Mohammad Hosein Nasr-Esfahani ,
Volume 13, Issue 4 (1-2013)
Abstract
Objective: Spinal cord injury (SCI) has become an especially challenging target in experimental neuroscience. Approach into the spinal cord is the interface among all different types of spinal cord injury modeling. The lower thoracic spinal cord has generated special interest due to the lower limbs’ spinal pattern generator position and presence of relative scales for behavioral assessment. However, a clear method with which to approach the thoracic spinal cord has yet to be determined. Methods : A total of 20 animals were subjected to this study. Following induction of anesthesia, the 10th thoracic vertebra were positioned, and muscles were retracted. Using the high speed rotary, the vertebral lamina were carefully thinned. As a final point, the reduced lamina was meticulously removed away to expose underlying spinal cord. Loco motor behavioral test (BBB) was implemented before and after surgery procedure. Results: This manuscript has presented the stepwise method to expose rat thoracic spinal cord. Whole procedure took less than an hour. Animals acquired complete BBB loco motor rating score before and after surgery indicating the safety of procedure. Conclusion: This article introduces simple and practical approach for the rat lower thoracic spine. The anatomical orientation, anesthesia , postoperative management , and common problems are discussed .
Kaveh Samadi, Ramin Salimnejad, Mohammad Jannat Dost, Behnam Ahadi, Zeinab Namjoo,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Curcumin is the main and active compound of turmeric and a yellow phenolic pigment that has antioxidant and anti-inflammatory properties. This study aimed to investigate the effect of curcumin on the morphology of cerebellar Purkinje neurons in rats with spinal cord injury.
Methods: In this experimental study, 9 rats were randomly divided into 3 groups: 1) spinal cord injury (SCI); 2) laminectomy; and 3) spinal cord injury+curcumin (SCI+curcumin). Spinal cord injury was induced by compression at the T10 segment of the spinal cord by placing a 50-gram weight for 5 minutes. In the treatment group, curcumin was administered at a dose of 100 mg/kg daily for 8 weeks by gavage. At the end of the 8th week, the BBB motor test was performed on the rats in all three groups, and after euthanasia, their cerebellum was removed and stained with hematoxylin and eosin. Finally, the tissue organization of the molecular, Purkinje, and granular layers and the tissue damage index were analyzed histologically.
Results: The results of our study showed that the morphology of cerebellar Purkinje cells changes after spinal cord injury, but treatment with curcumin can reduce the destruction of these cells and maintain their typical morphological characteristics.
Conclusion: Based on the present study, curcumin can reduce the destruction of cerebellar Purkinje neurons in rats with spinal cord injury and also lead to motor improvement in these animals.
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