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Background & objectives: In recent years, regarding the side effects of chemical drugs, the use of medicinal plants has increased due to their low side effects, low costs and effective compounds. The aim of this study was to investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic effects of hydroalcoholic extract of Rosa canina L. fruit in male mice.
Methods: In this experimental study, 120 male BALB/c mice weighing 23-30 g were used. In each test, the mice were divided into 5 groups (in each group, n=6), including control group, positive control and three experimental groups treated intraperitoneally with hydroalcoholic extract of Rosa canina L. fruit at doses of 100, 200 and 400 mg/kg respectively. The anti-inflammatory and antipyretic activities were measured using xylene-induced ear edema and brewer’s yeast-induced pyrexia tests, respectively. In addition, the antinociceptive activity was measured using the abdominal constrictions induced by acetic acid and formalin tests. The data were analyzed by SPSS statistical software and One Way ANOVA test. The level of significance was set at   p<0.05.
Results: 200 (p<0.05) and 400 mg/kg (p<0.001) doses of extract reduced significantly inflammation. Doses of 100 (p<0.05), 200 (p<0.01) and 400 (p<0.001 significantly reduced pain in the abdominal constriction test and dose of 400 mg/kg (p<0.05) decreased the chronic pain in formalin test. Extract treatment did not reduce fever in any of the existing doses.
Conclusions: The findings of this study suggest that Rosa canina L. fruit has anti-inflammatory and visceral analgesic activity, which may be due to its antioxidant potential.
 

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Background & objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) - induced peptic ulcer disease is a common gastrointestinal disorder affecting many people worldwide. Rosa canina L. is a member of Rosa species that has been widely used as an herbal medicine in many countries. Rosa canina has therapeutic effects against various disorders through its antioxidant, anti-inflammatory and cytoprotective properties. The aim of the present study was to evaluate the potential beneficial effect of Rosa canina on indomethacin-induced ulceration in mice.
Methods: Experiments were performed on male Swiss albino mice. Indomethacin (80 mg/kg, orally) was used to induce gastric ulceration. The extract of Rosa canina fruits (200 and 400 mg/kg/day) was given orally five days before the administration of indomethacin. Normal mice were used as a normal control group.
Results: Macroscopic evaluation of gastric mucosa revealed that indomethacin administration (80 mg/kg) produced apparent gastric mucosal ulcers, while pretreatment with Rosa canina (200 and 400 mg/kg) effectively protected gastric mucosa against indomethacin induced ulcers. Rosa canina significantly increased the level of glutathione (GSH) and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO) in the gastric tissues compared with those in the control group.
Conclusion: Oral treatment with the Rosa canina fruit extract decreased the gastric ulcer induced by indomethacin through antioxidant and anti-inflammatory mechanisms

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Background & objectives: Paraquat is a toxic herbicide that is widely used in many countries. Paraquat selectively accumulates in the lung tissue and leads to severe pulmonary injury through the oxidative and inflammatory processes. The plant Rosa canina L. has been used for long years as an herbal medicine throughout the world. Rosa canina L. is a member of Rosacea family and shows therapeutic effects against numerous disorders by its antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidant effect of Rosa canina fruits on the paraquat induced lung injury in a mouse model.
Methods: Animal experiments were performed on male NMRI mice. Paraquat was injected at a single dose (20 mg/kg, ip) to induce pulmonary damage in mice. The extract of Rosa canina fruits (200 and 400 mg/kg/day, orally) administered by gavage for four days after the injection of paraquat. The treated mice were compared to normal mice as a control group. At the end of the experiment, lung tissue samples were collected for biochemical analysis.
Results: The results showed that administration of paraquat caused an oxidant-antioxidant imbalance in the lung tissue. However, treatment with Rosa canina increased the levels of glutathione (GSH) and catalase (CAT) antioxidants and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO) in the lung tissues compared with those in the paraquat group.
Conclusion: Treatment of paraquat-exposed mice with the extract of Rosa canina fruits improved oxidant-antioxidant balance in the lung tissue of mice. In other words, the present study demonstrated that Rosa canina has remarkable antioxidant effects against paraquat induced oxidative damage.