Background & Objectives : Panel-reactive antibody (PRA) is a routine test to evaluate for sensitized human leukocyte antigens (HLA) before kidney transplantation. The present study evaluates the correlation of renin-angiotensin system (RAS) polymorphisms with the level of PRA in renal transplant candidates.

  Methods: This study included 108 renal transplant candidates. The current patients sera were screened by standard complement-dependent microlymphocytotoxicity technique. RAS polymorphisms were determined by polymerase chain reaction. PRA<10, 10-29, 30-49, and ≥50 considered as negative, mild, moderate, and highly positive PRA, respectively.

  Results: Twelve (11.1%) patients had positive PRA, among them 10 (83.3%) had mild and 2 (16.7%) of them had moderate PRA levels we had no highly positive PRA. Ninety-six of cases (88.9%) were negative for PRA. There was no significant correlation between discrete RAS polymorphisms (alone or together) and the degree of panel antibody reactivity (P>0.05).

 Conclusion: We suggest that none of the RAS polymorphisms could predict the positivity degree of PRA level.

 Background & Objective: As renin-angiotensin system (RAS) activity could affect the severity of oxidative stress and inflammatory markers the effect of enalapril and losartan on these markers in renal transplant recipients (RTRs) with RAS polymorphisms was assessed.

 Methods: After determination of RAS genotypes including angiotensin converting enzyme (ACE I/D), Angiotensinogen (AGT M235T) and angiotensin II type 1 receptor (ATR1 A1166C) by PCR, seventy-six RTRs recruited to four groups randomly: first group (17 patients) and second group (24 patients) were treated with E (E⁺: 10mg/daily) and L (L⁺: 50 mg/daily) alone, respectively. The third group (17 patients as positive control) received E+L (E⁺L⁺: 10mg/daily + 50 mg/daily) and the 4^th group (18 patients as negative control) received no medication (E^-L^-). Hs-CRP and total anti-oxidant (TA) as inflammatory and anti-oxidative markers were measured after 2 months. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and hs-CRP and TA were retested.

 Results: Following up the patients (after 2, 4 months of treatment) in treated groups revealed that hs-CRP and TA levels were significantly decreased and increased (consequently) in E⁺L⁺, L⁺, E⁺ groups (P<0.05). On analyzing the relationship between RAS polymorphisms with baseline hs-CRP and TA levels, CC genotype of ATR1 had lower hs-CRP levels (P=0.04). But none of the RAS polymorphisms could predict the anti-oxidative and anti-inflammatory response rate to the drugs (P>0.05).

 Conclusion: E and/or L reduce hs-CRP and increase TA regardless of the RAS genotypes.

  Background and objectives: Quality of life is an important aspect in the evaluation of different therapeutic interventions. Quality of life assessment helps to find patients problem and revise their therapeutic method. The purpose of this study was to evaluate the life quality among patients receiving renal transplantation in comparison with hemodialysis in Ardabil university of Medical Sciences.

  Method: In this comparative study a total of 70 patients with renal transplantation and 93 hemodialytic patients were chosen through census sampling. An interview based questionnaire was administered for subjects to gather information on demographic characteristics and kidney disease quality of life scale.

  Results: Findings show that, 65.7 percent of transplanted patients reported their quality of life as good. While, in 65.6 percent of hemodialytic patients life quality was moderate. The average quality of life score in transplanted patients was 95.44 ± 12.44 SD while it was 83.53 ± 14.89 for the patients under dialyzes. The difference between the two groups were significant (p< 0/001).