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Showing 110 results for Rat
Masoud Entezari-Asl , Mohammadreza Ghodrati , Hamid Ebadizare , Khatereh Isazadehfar ,
Volume 2, Issue 2 (6-2002)
Abstract
Background & objective : Recovery state or post - anesthetic awakening is one of the most dangerous anesthetic stages . Respiratory, cardiovascular and other complications such as nausea, vomiting, shivering, pain and restlessness have been reported . This study designed to investigate prevalence of this complications and its probable risk factors in Ardabil Fatemi and Alavi hospitals. Methods : In this prospective study, 160 patients were selected in Alavi and Fatemi hospitals during winter of 2001. We completed a sheath for everybody about their history of medical diseases, pervious history of anesthesia, addiction, drug abuse, smoking, physical class of ASA, type of anesthesia, time and place of surgery . Data was analyzed by SPSS software. Results : These results were obtained in patients after surgery in recovery room: shivering
36.3 % , pain 26.9 % , restlessness 21.3 % , respiratory complications 13.8 % , cardiovascular complications 12 % , nausea and vomiting 8.8 % . We found significant correlation between some risk factors with complications, e. g: shivering with history of medical diseases, drug abuse and place of surgery and so, pain with restlessness, respiratory complication and place of surgery . Conclusion : This study according to similar studies revealed higher prevalence of some of post - anesthetic complications as shivering, pain and restlessness in our samples .
Saryeh Golmohammadlo , Farzaneh Bromand ,
Volume 2, Issue 2 (6-2002)
Abstract
Background & Objective : One percent of emergency ward receptions are acute abdomen problems. Gynecological causes include 20%of them. Relation between physiology of women and abdominal pains challenges diagnosis. Clinical diagnosis in these cases have no substitution and studies about accuracy of diagnosis helps to correct future clinical diagnosis . Methods : A cross-sectional study conducted over 148 women whom admitted for acute abdomen causes and operation in Urmia Kosar Hospital during 1375-79. Data of history and Para clinical and also pre and post operation diagnosis Collected by related questionnaire and interpreted . Results : Ectopic pregnancy (39.9%), ruptured ovarian cyst (23.6%), ovarian cyst torsion(18.2 % ), abdomen masses unrelated to gynecological system (4.1%), were respectively common causes. Two cases were normal. Five appendicitis cases diagnosed after laparatomy. We observed 76% similarity of diagnosis before and after laparatomy, which coordinated with other studies. Ectopic pregnancy with 66 cases of diagnosis before and 53cases confirmation after operation was related to over diagnosis and 22 cases of ovarian cyst ruptures before operation and 36 cases of them after operation were related to under diagnosis . Conclusion : Considering the results, common causes of acute abdomen incur most frequent misdiagnoses. So keeping in mind that sometimes common cases appear atypically and on time using of paraclinic measures can help the surgeon to diagnose correctly before laparatomy .
, , , ,
Volume 4, Issue 1 (4-2004)
Abstract
Background & Objective: Spinal anesthesia is one of the usual techniques in the surgery of hip fractures among the aged. On the other hand the hemodynamic complications of this method and the treatment of these complications by abundant Ir liquids and drugs such as Ephedrin and phenylephedrin have potential risk for aged patients. Intrathecal opioids have synergistic effects on the duration and quality of spinal block. Thus a number of efforts have been made to prevent the hemodynamic complications and probability of inadequate block by decreasing the dosage of local anesthetic drug and adding opioid drugs to it. This study investigates the hemodynamic effects and the quality of spinal anesthesia using the above-mentioned method. Methods: Forty-six patients above 60 years of age with hip fracture were randomized into 2 groups (A and B). Group A received a spinal of hyper tonic bupivacaine (5 mg) and fentanyl (20 m g) and group B received 12.5 mg of hypertonic bupivacaine for spinal anesthesia. Vital signs before and during the surgery, quality and quantity of blockage, amount of fluid and Ephedrine used, were recorded every 5 minutes. Results: MAP (Mean Arterial Pressure) fall and the dosage and frequency of ephedrine consumption were significantly different in two groups. MAP decrease in-group A was 23.6 ± 10.79 and in-group B it was 36 ± 11.1 (p=0.001). The average requirement of ephedrine in the groups were 2.25 ± 3.49 mg in-group A and 10 ± 8.45 mg in-group B (P=0.001). The average occurrence of hypotension and ephedrine usage was 0.71 ± 1.08 times in-group A and 2.91 ± 2.94 times in-group B (p=0.001). 29 % of group A had pain in the terminal stage of surgery but this amount in-group B was 13.6%. Tachycardia was 29.2 % in-group A and 68.2 % in group B (p=0.001). Conclusions: Adding 20 m g fentanyl to bupivacaine and decreasing its dosage can prevent the complications of intrathecal anesthesia. (MAP fall and the tachycardia occurred in the process of its treatment) to a great extent. But to lower the incidence of failure and obtain reliable block, more controlled studies must be accomplished.
Eiraj Lotfinia, Masoud Niazie Gazani , Shahnam Baboli, Marouf Ansari ,
Volume 4, Issue 1 (4-2004)
Abstract
Paraplegia can be caused by different factors like rupture or repair of the aortic aneurysm or aortic thrombosis, aortic dissection, anterior spinal cord artery emboli, coagulation disorders and lupus disease, all of which cause impaired spinal cord blood flow and spinal cord ischemia. In addition, hypotension may be the cause of spinal cord infarction but Medline researches have reported a few cases of spinal cord infarction in patients laparotomized for the reasons other than aortic lesions. In this paper we report one case of paraplegia who had experienced spinal infarction and paraplegia after internal bleeding and two times laparatomies due to long lasting hypotension. In this case regarding the patient ’ s age, occupation and physical health, the possibility of cardiovascular lesions and consequent thromboembolism seems very unlikely. Furthermore, considering the two operations performed and the temporal space between them, the only factor that could have led to ischemia and infarction of the spinal cord in this patient is long-standing hypotension.
Ali Nemati , Hosein Ali Mohammadi , Hamdollah Panahpoor , Seyedhashem Sezavar ,
Volume 4, Issue 1 (4-2004)
Abstract
Background & Objective: Foods of high fat may increase the risk of coagulation heart attacks. They can also increase coagulating factors and lead to higher mortality due to cardiovascular diseases and heart attacks. The aim of this study was to find out the effect of saturated (butter) and unsaturated (sunflower oil) fat intake on coagulating factors such as factor VII and fibrinogen as well as Bt, serum cholesterol and triglycerides. Methods: In this clinical trial 46 male healthy individuals from Ardabil University of Medical Sciences took part in this study (age: 18-28 years old) in 2002. These individuals were divided into two groups. The first group consumed 30 g of butter and the second group took 30g of sunflower oil everyday, for 14 days. Before the fat intake and at the end of first and second week blood sample was taken test to fibrinogen, factor VII, cholesterol, BT and triglycerid. Also during the study the 24-hour food-recall was taken three days a week. The collected data were analyzed with SPSS and Food Processor. Results: The results indicated that butter intake increases factor VII significantly at the end of the first and second week (p<0.05). But no significant about sunflower oil. BT decreased after butter intake at the end of first and second week. This decrease was significant at the end of first week (p<0.05). Bt increased significantly after sunflower oil intake at the end of second week (p<0.05). Serum fibrinogen after butter intake decreased significantly at the end of first and second week (p<0.05), but was not significant after sunflower oil intake (p<0.05). There was no significant difference in serum cholesterol and triglyceride level after butter intake, but at the end of first week after sunflower intake serum cholesterol decreased significantly (p<0.05). Conclusions: We concluded that the intake of saturated fat can affect factors in a short period of time and sunflower oil can decrease serum cholesterol level and as results increase the bleeding time.
Farnaz Ehdaivand , Masoumeh Rostamnegad , Homayoun Sadeghi , Nayereh Aminisani,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Cesarean section is one of the most common surgeries in women. In developed countries the rate of cesarean section is reported to be 21.2%. In Iran, the rate of cesarean section is even higher than the international norms. In a study in Ardabil, in 2001, cesarean section rate came out to be 42.86%. Postoperative pain after cesarean is one of the complications that all mothers experience in one-way or another. Besides bothering mother it can disorder newborn feeding, ambulation of mother and bonding between newborn and mother if it is not controlled effectively. This study was conducted to compare the effect of intramuscular Methadone and Diclofenac suppository for pain relief after cesarean section in Alavi hospital, Ardabil. Methods: This study was a double blind clinical trial. 56 women who experienced cesarean section for the first time were randomly divided into two groups. Diclofenac suppository (100 mg every 8hr) was given to first group and Methadone (5 mg every 8hr) was injected to the second group for 24 hours. Then, the severity of pain was measured with numerical scoring in serial postoperative visits. The data were analyzed by SPSS software using descriptive and analytical statistics such as chi-square and ANOVA. Results: The findings indicated that the severity of pain in 2nd, 3rd and 4th postoperative visits was significantly lower in patients who received Diclofenac suppositories than the other group (p<0.05). But overall, there was no statistically significant difference between the pain severity in Methadone receiving group (Mean & SD= 5.85 ± 3.5) and Diclofenac receiving group (Mean & SD= 6.46 ± 2.9). Conclusion: There was no significant difference between Diclofenac suppository and Methadone in terms of decreasing the postoperative pain after cesarean section. However, regarding the restrictions in the use of opioids, Diclofenac can be a suitable replacement for these drugs.
Farzad Izadi , Seyedbehzad Pousti , Fathollah Mousavi , Mohammad Mohseni , Abtin Doroudinia ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Recurrent respiratory papillomatosis (RRP) is the most common benign laryngeal tumor and the second common cause for hoarseness in children. Despite its omplete benign histology, it has a great tendency to spread through the respiratory track and frequent recurrences may occur following surgery, possibly due to the virus survival in apparently healthy adjacent tissues. According to the most recent evident experiences, the treatment of choice for RRP disease is repetitive resections with CO2 laser. The present study evaluates the efficacy of adjuvant medical therapies for eradication of this disease in affected children. Methods : This was an experimental study with sequential control (self-control). The subjects were children who referred to ENT-H&N surgery dept. of Hazrat-e- Rasoul hospital in Tehran between Mar 1998 and Mar 2001 with chief complaint of hoarseness and respiratory obstruction. Among these children patients with confirmed diagnosis of RRP were selected as study samples and the effect of acyclovir and alpha-interferon combination in reducing the severity and recurrence of RRP was evaluated. Results: Totally 18 patients entered this study (10 (55.5%) females and 8 (44.5%) males). The mean age of the patients was 6.5 and 94% of them were the first child of young mothers (under 25 years of age). The signs of respiratory obstruction in most of the cases with a mild to moderate severity was the main cause of referral in 45% of the subjects. Laryngeal lesions were mostly superficial and limited to glottis region. Severity and spread of RRP disease was greater in children under 3, which led to tracheotomy in 3 of them. The combined administration of alpha-interferon and acyclovir, made a significant reduction in disease severity and spread in 55.6% of the patients. Conclusion : The findings of this study indicated that combination of acyclovir and alpha-interferon can be effective in reducing RRP recurrences and severity. Nevertheless, because of small sample size(due to rarity of RRP), Further multi-institutional studies are required to obtain a greater sample size and more valid results.
Habib Ojaghi, Rahim Masoumi , Elham Ghaebi ,
Volume 5, Issue 2 (6-2005)
Abstract
Background & Objectives: Pterygium is a common ophthalmic disease which can cause astigmatism and restriction of visual field and cosmetic problems. Regarding the high recurrence rate using the common methods and because similar studies have never been done in Ardabil province, we decided to study the recurrence rate of pterygium after surgery with intraoperative application of mitomycin C. Methods: In this descriptive cross-sectional study all patients with primary pterygium who had undergone surgery between February 2001 and September 2003 were assessed and followed up for postoperative examinations. The findings were then statistically analysed. Results: In this study 83 eyes of 80 patients were examined. The highest prevalence of pterygium was in age group 31-40. Most of the patients had undergone unilateral surgery. In terms of size the most prevalence of pterygium was 3-4 mm. 4 cases (4.8%) had recurence one of which was observed in the first 2 months after surgery and three others in 2-6 months after it. In 50% of the recurred cases pterygium was 4 mm and in the rest of them it was 5 mm in size. After operation just 2 cases had granuloma which did not respond to topical corticosteroids and were excised by surgery. Conclusion: This study shows that the recurrence rate of pterygium after surgery with intraoperative mitomycin C is very low and this method has no serious complications. Using this method routinely is recommended. Moreover the recurrernce rate of pterygium is associated with its size.
Ahmad Hashemzadeh, Farhad Heidarian,
Volume 5, Issue 2 (6-2005)
Abstract
Background & Objectives: Respiratory distress is one of the most important causes of children admission in hospitals. In most cases, it is due to pneumonia, asthma or acute bronchiolitis. Since theses diseases have a lot of symptoms in common, we decided to study these disorders in more details to facilitate the appropriate diagnosis and treatment based on clinical, laboratory and radiologic findings. Methods: 238 children who suffered from respiratory distress and were admitted to pediatric ward in Ghaem hospital were studied. This descriptive study was performed during 3 years including 2 retrospective and one prospective year. The relationship between variables was analyzed using chi-square test. Results: The patients were six months to five years old. Pneumonia (40.3%) asthma (30.3%) and bronchiolotis (16.8%) were the most common causes of respiratory distress. Totally, 61.1% of the patients were male. The mean age of the patients was 10.3 months in bronchiolitis and 36.6 months for asthma. The most common symptom among these three diseases was tachypnea. Most of the patients were admitted in winter and fall respectively. The main radiologic pattern in pneumonia was pulmonary infiltration and for asthma and acute bronchiolitis it was pulmonary hyperinflation. Conclusion: Proper attention to signs and symptoms as well as laboratory and radiologic fndings is necessary for accurate diagnosis. In this study the most common cause of respiratory distress in children under 5 was found to be pneumonia, asthma and bronchiolitis respectively.
Khatere Seylani, Masoome Aghamohammadi, Khlil Rostami, Vadood Noroozi,
Volume 5, Issue 3 (9-2005)
Abstract
Background & Objective: Postoperative nausea and vomiting is the most common complication of anesthesia with an approximate prevalence of 30% up to 70% (in high risk patients). In recent years several articles have investigated the effects of antiemetic and anesthetic drugs on postoperative nausea and vomiting, but the nonpharmacological methods, which are cost-effective and have no side effects, are rare. Since it is essential for patients to be on fast before surgeries which require general anesthesia, occurrence of dehydration and extra cellular fluid volume deficit and subsequently nausea and vomiting are expected and anticipated. Thus in this study the effect of preoperative intravenous fluid on postoperative nausea and vomiting was explored. Methods: This clinical trial study was performed in two experimental and control groups, with 30 subjects in each. Experimental group were given a 1- liter bolus of intravenous normal saline preoperatively in addition to routine IV fluid. Finally the incidence of postoperative nausea and vomiting was observed and compared between two groups. Results : According to statistical tests, the differences between age, preoperative and postoperative NPO duration, use of antiemetics and the duration of hospitalization in two groups were statistically significant but the differences between other demographic variables and the volume of intraoperative intravenous fluid received during the surgery were not. Results showed that experimental group had significantly lower incidence of nausea and vomiting (20% and 10% respectively) in comparison with control group (50%). According to chi-square test, the rate of postoperative nausea and vomiting was significantly different in two groups. (p=0.015 and p=0.001 respectively) Also, preoperative NPO duration had significant relationship with postoperative vomiting (p= 0.05). Conclusion: Regarding the positive effect of intravenous fluid therapy on postoperative nausea and vomiting as a cost effective and harmless method in surgery, its use is recommended.
Firooz Amani , Manoogehr Barak , Naiere Aminisani, Mohammad Hosein Dehghan ,
Volume 5, Issue 4 (12-2005)
Abstract
Background & Objectives: Providing, maintainance and promotion of neonatal health as a special high-risk group has a special role in heath services. According to statistics, 4 million out of 130 million neonates, born every year, die in the first week of their life. 99% of this mortality takes place in developing countries. 38% of the deaths below the age of 5 belongs to neonatal deaths. To decrease this mortality, some factors such as mother condition (including health care both before and after pregnancy), perinatal factors and life-threatening factors in the first 28 days after birth. This study was performed in hospitals under Ardabil University of Medical Sciences to determine the related factors of neonatal mortality. Methods: This case-control study was conducted on 160 neonatals (80 cases of neonatal deaths and 80 live births as controls). The demographic data of two groups were separately analyzed to obtain descriptive results. Also the most common causes of neonatal mortality were obtained through studying cases. Moreover, the parents of live neonates were asked questions to evaluate the effect of social factors. Finally all of these related factors were compared. Results: From 160 neonates under study, 71 (44.4%) were female and others were male. Neonatal mortality in males was 1.3 times as much as that in females. 16(12.1%) mothers had history of still birth. 18(11.3%) mothers were illiterate and 27 (16.9%) had college education. 31(19.4%) neonates were under 1500gr, 42 (26.3%) 1500- 2500gr and others above 2500 gr. 37 (46.3%) mothers in case group and 24(30%) in control had no access to transportation facilities. The most common causes for neonatal mortality were prematurity with 44 (55.1%) cases and aspiration, septicemia, asphyxia each one with 4 (2.5%) cases. There were statistically significant relationship between neonatal mortality rate on the one hand and birth weight, access to transportation facilities and mothers, living place (rural or urban) (p=0.023). Conclusion: According to the results, factors such as birth weight, access to transportation facilities as well as the mothers’ living location (rural or urban) were determining factors in the neonatal mortality. Some measures seem necessary to by taken in order to decrease the effect of thses factors.
Fahimeh Sehhatie Shafaie , Alireza Nikniaz, Hosein Koushavar , Haleh Sadegie,
Volume 6, Issue 3 (9-2006)
Abstract
Background and Objectives: Children are one of the most vulnerable groups of society. Any qualitative and quantitative problem in offering health services to them is a main health and social problem. Cooperative health centers for the first time in Iran were established in East Azerbaijan as a proper strategy for solving health problems and limitations of expansion of government health centers. This study was conducted to evaluate their quality of services to children under one year old in comparison with governmental health centers. Methods: This descriptive and cross-sectional study was done on 7 cooperative health centers and 14 neighboring government health centers selected by convenience method. Data were collected by filling checklists obtained from observation of services offered to these children by healthcare personnel as well as studying the children's health records. Descriptive (absolute and percent frequency distribution, mean and standard deviation) and inferential (independent samples t-test) statistics were used for analyzing the data. Results: The findings showed that the quality of health care for children under one was good (85.71%) in cooperative centers and moderate (78.57%) in government health centers and their statistical difference was significant (P=0.002). In terms of services about growth monitoring of child, nutrition of infant and mothers' education, cooperative health centers had better practice compared to government health centers (P= 0.001, 0.007and 0.023respectively). Regarding the equipment both centers had good facilities (85.71%) and there was no statistically significant difference between them (P= 0.912). Conclusion: The results showed that, in most cases, the quality of health care given to children under one was good in cooperative health centers and moderate in government centers. This optimum performance of cooperative centers can encourage health care authorities to plan for the expansion of such centers to compensate for the deficiencies of health services especially in children under one year old.
Rahman Parniya , Darioush Savadi Oskuei , Seyedabbas Mousavi ,
Volume 6, Issue 4 (12-2006)
Abstract
Background & Objectives: Stroke is the third cause of mortality after cardiovascular diseases and cancer. It is also the most common debilitating neurologic disorder. Considering the high prevalence of intracerebral hemorrhage (ICH) and its mortality, it seems quite necessary to study the frequency of ICH risk factors and its mortality related to size and region of hemorrhage. Methods: 157 ICH patient units were studied to determine hemorrhage size and region via CT Scan reports. Patients were followed to record the mortality and a questionnaire was filled out for them. The data were analysed by SPSS version 13. Results: Females constituted 57.9% of the 157 patients and the rest were males. Mortality rate was 37.6%. Most of the patients were in 70-79 years age group. Hemorrhage had the highest frequency found in putamen (39.4%). Hemorrhage size less than 20 cm3 had the highest frequency among living patients and hemorrhage size in a range of 20-100 cm3 was most common among expired patients. There was a statistically significant relationship between mortality and hemorrhage size (P<0.05). Intraventricular hemorrhage was more frequent among expired patients (p<0.05). There was also a statistically significant relationship between a history of cardiovascular disease and mortality rate (P<0.05). Conclusions: Intraventricular hemorrhage and hemorrhage size were significantly related to mortality rate.
Vadood Norouzi , Eiraj Feizy , Firooz Amani , Pouneh Zamani ,
Volume 6, Issue 4 (12-2006)
Abstract
Background & Objectives: Pain acts as a defensive mechanism of body, which occurs following tissue damage. It is expected in surgical wounds. With regard to negative clinical outcomes resulting from surgery pain, this study was conducted to investigate the quality of pain control after appendectomy. Methods: In this descriptive, cross- sectional and prospective study, 200 patients undergoing appendectomy were randomly selected. Pain control in all of the patients was managed for 8 hours using narcotics injected intramuscularly. The patients were studied during 12 hours after surgery. The rating scale of 0-10 grade was used to estimate pain severity. The collected data were analysed by SPSS. Results: From 200 patients experiencing appendectomy, 101 (50.5%) were female and 99 (49.5%) were male. Pain was controlled with pethidine, methadon and pentazocin in 123 (61.5%), 51 (25.5%) and 26 (13%) patients, respectively. In 98 (49%) patients there was severe pain following the surgery. The most severe pain belonged to 21 (80.7%) patients who received pentazocin. Conclusions: With regard to multiple complications and problems resulting from pain after appendectomy, careful control of pain and more attention is necessary.
Mokhtar Mokhtari , Mehrdad Shariatie , Nazanin Tadayon ,
Volume 7, Issue 1 (4-2007)
Abstract
Background & Objectives: Spironolactone is a diuretic and antiandrogenic drug and is used in the treatment of hypertention 'secondary hyprealdosteronism congestive heart failure' cirrhosis of the liver, nephrotic syndrome 'androgenic alopecia' gynecomastia and hirsutism. In this research, the effects of spironolactone on the serum LH, FSH, testosterone, dihydrotestosterone, and changes in body weight and testicular tissue in adult male rats, were studied. Methods: For this purpose 190 10 g male wistar rats (n=40) were randomly divided into the following grups: control, sham operated (received water) and 25, 50, 100 mg/kg oral spironolactone treated groups. After 14 days body weight and testis weight under laboratory methods, were measured and blood samples were taken from heart and used for the measuring of LH/FSH/testosterone and dihydrotestosterone and then the rates' testes, in order to evaluate the histological changes, were removed and weighed and after obtaining tissue section and staining through HE, they were studied. Results: Serum LH level showed a significant increase and testosterone and dihydrotestosterone levels showed asignigicant decrease in 100mg/kg spironolactone treated group ( p 0.05 ) and there was no significant difference among serum FSH level, body weight and testicular weight as compared to control group. Conclusion: It can be concluded that oral administration of spironolactone maximum dose for 14 days could increase serum LHlevel and decrease testosterone and dihydrotestosterone levels.
Nayereh Amini Sani , Manoochehr Barak , Seyedmorteza Shamshirgaran , Firooz Amani , Saadollah Mohammadi , Benyamin Fazli ,
Volume 7, Issue 2 (6-2007)
Abstract
Background & Objectives: The high incidence of low birth weight (LBW) occurs in developing countries, and diarrhea and respiratory infections are the main causes of infant mortality and morbidity. This study was done to find out whether there was a growth or morbidity response to zinc supplememttion, among LBW infants during the first 6 mo of life. Methods: The study was a randomized, placebo-controlled, and double-blind trial study. LBW infants were given daily for 6mo 5mg zn, or a placebo. Questionnairs were filled out during the study by a pediatrician and a GP. Anthropometric measurements were made at 0, 4, 8, 12, 16, 20 and 24 wk via home visits by trained interviewers. Results: Baseline characteristics were similar in zinc and placebo groups. Weight gain in zinc group was significantly higher that of placebo group between 1 to 6 months (p=0.036). Length and head circumference gain were also greater in zinc group than in placebo groups, (p=0.04, p<0.001). The episodes of upper respiratory infections was greater in placebo group than zinc group (mean Episodes in zinc groups= 1.7 and in placebo group was 3) and there was significant difference between two groups (p=0.005). 8 Cases of lower respiratory infections in placebo group and 5 cases in zinc group were observed, but it was not significan diarrheal episods were observed only in placebo groups. Conclusion: It was found that low birth weight infants had better growth and lower morbidity during the first 6 months of life by receiving zinc supplementation.
Fariba Kahnamouei, Mohammadali Mohammadi, Farideh Mostafazadeh, Afshar Ebrahimi,
Volume 7, Issue 2 (6-2007)
Abstract
Backgrond & Objectives: Oligohydramnios is a disorder which is followed by unpleasant outcomes for fetus that can lead to termination of pregnancy before term and preterm delivery. For these patients' increase in gestational period and prevention of preterm delivery is the most important act. In this study the effect of intravenous and oral hydration therapy in increasing duration of gestation in patient with oligohydramnios was evaluated. Methods: In this study, the population was devided into two case and control groups with 30 female individual who were found to have oligohydramnios in course of hospital admission according to on sonographic results. Patients were randomly put in case or control groups. Case group were given 3-4 liter normal salin for 1 week and then were given oral hydration solution until the end of pregnancy, In each group whenever it was found that pregnancy was not possible the pregnancy continuance was stopped. Data collection was through history, physical examination completing relevant questionnaire and findings of sonography and in order to see the relationship among finding s, kitest and t-test from SPSS software were used. Results: The age means of case and control groups were 25 and 24 respectively. The mean of pregnancy duration from the diagnosis time in case group was 30.2 weeks and in control group 31.8 weeks. The mean of pregnancy terminatior in case group was 34.6 weeks and in control group 34.2. In increasing duration of pregnancy in case and control group. It was concluded that intravenous and oral Hydration therapy cause incerease in duration of pregnancy in patients suffering from oligo Hydraminos. According to the results of this study and significance of the difference.
Simin Atashkhoii, Rasool Azarfarin , Zahra Fardiazar ,
Volume 7, Issue 3 (9-2007)
Abstract
Background & Objectives: A common side effect associated with succinylcoline is postoperative myalgia. The pathogenesis of this myalgia is still unclear therefore there is no ideal method of decreasing the rate and severity of fasciculation and postoperative myalgia. The aim of this prospective and randomized study was to evaluate the influence of low-dose succinylcholine for tracheal intubation on the rate and severity of fasciculation and postoperative myalgia. Methods: In this study, 60 patients of ASA physical grading I or II were randomly entered into two groups of 30 patients each. One fasciculation was evaluated on the basis of Mingus and myalgia on the basis of Harvey Induction of anesthesia was performed with fentanyl/thiopentone, and then succinylcholine 1 mg/kg (control group) and 0.6 mg/kg (case group) were administered to patients for tracheal intubation. Results: There was not fasciculation in 50% (15 patients) of study group and on the rest no severe fasciculation occurred. Furthermore, the severity of fasciculation in the study group was significantly lower than that of control group (p<0.0001). In 16 (53.3%) patients of study group and 4 (13.3%) of control group myalgia were not occurred. Severity of myalgia was also significantly lower in study group than the control group (p<0.0001). Acceptable intubating conditions in all patients of two groups. Conclusion: Decreasing the dose of succinylcholine (from 1 mg/kg to 0.6 mg/kg) both provides acceptable intubation conditions, and reduces the rate and intensity of succinylcholine induced fasciculation and postoperative myalgia.
Masoud Entezariasl, Khatereh Isazadefar , Ghodrat Akhavanakbari,
Volume 7, Issue 3 (9-2007)
Abstract
Background & Objectives: Postoperative nausea and vomiting are among the main complication after anesthesia and various methods are used for the prevention of this complication. In this study, the effect of the pre induction use of 10mg Metoclopramide’ 8 mg Dexamethasone and the combination of the both, on decreasing in the rate of nausea and vomiting after cataract surgery in intravenous anesthesia is compared with placebo. Methods: In this double blind clinical trial, one hundred patients of cataract surgery who are appropriate for this study were, randomly divided in to four groups. In the group of placebo (P), 2cc normal saline, in group (M), 10mg metoclopramide, in group (D), 8mg Dexamethasone, and in group (M+D), 10mg metoclopramide and 8 mg Dexamethasone, one minute before the induction of anesthesia was injected. Patients were received the anesthetic drugs in the sameway and after the tracheal intubation infusion of propofol was started. After the end of surgical operation, the appearance of nausea and vomiting in the recovery room and also 6 and 24 hours after the surgery are recorded in the patients' information forms. Finally the data were analysed by statistical software of SPSS and the statistical tests. Results: After the use of these drugs, the rate of nausea in the recovery room decreased from 44% in placebo to 20% in metoclopromide group, 16% in Dexamethasone group, and 8% in combination of metoclopromide and Dexamethasone and the rate of vomiting decreased from 20% in placebo group to 4% in metoclopromide group, 4% in Dexamethasone group, and 0% in combination of these two drugs, both the nausea and vomiting the effect of combination of metoclopromide and Dexamethasone in decreasing of postoperative mausea and vomiting was significant (P<0.05). The 24 hour following of nausea and vomiting, also had the same results. Conclusion: With regrard to the results of this study, implication of the combination of 10mg metoclopromide and 8mg Dexamethasone before the induction of anesthesia remarkably decreased the rate of postoperative nausea and vomiting and is useful for the high risk groups for this complication especially in out patient surgery.
Davar Amani , Mohammadhasan Zahir , Mojtaba Karimzadeh, Sadegh Feizollah Zadeh, Mohammadhosein Dehghan ,
Volume 7, Issue 4 (12-2007)
Abstract
Background & Objective: Tumor-infiltrating lymphocytes (TILs) develop as recognition and defense against malignant cells by the host immune system. T cells are the most tumor infiltrating immune cells. There are controversial data about intratumor T cells and many have proposed diverse mechanisms for dysfunction of TILs. The aim of this study is analyzing Tumor Infiltrating T lymphocytes in patients with breast cancer by immunophenotyping. Methods: Sixteen women suffering from breast cancer were examined thirteen of them were confirmed histologically to be invasive ductal carcinoma (IDC). Tissue samples from patients and matched control group were processed for analysis by flow cytometry. Results: Results indicated that human breast cancer contain variable numbers of TILs. No significant changes in the percent of intratumor CD45+, CD3+ and CD3+/CD45+ cells were observed between studied group. Also there were no significant differences between cancer patients (group 1 and 2) and control group in the case of infiltration and activation status of T cells subpopulations. CD4+ cells in IDC patients and CD8+ cells in patients with other tumors (ILC+AMC) were the most infiltrated TILs. Intratumor TCD8+ cells expressed HLA-DR markers significantly more than CD25 as activation marker. In this investigation we could not find any correlation between TIL and both size and clinical stages of tumor. Conclusion: An immune infiltrate is an invariable finding in breast cancers, with considering the activation marker expression, TIL may be activated, albeit partially. Understanding the insensitive and/or suppressive nature of cancer cells to the immune system may provide important insights into tumor escape mechanisms as well as the development of anti-cancer strategies.
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