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Showing 1 results for Non-Coding Rnas
Parham Mansouri, Dariush Shanehbandi,
Volume 25, Issue 2 (7-2025)
Abstract
Colorectal cancer (CRC) remains one of the most prevalent gastrointestinal malignancies, posing significant challenges in diagnosis and treatment. Recent research has highlighted exosomes and their non-coding RNA (ncRNA) cargo as key players in tumor progression and novel diagnostic tools. Exosomes are extracellular vesicles (50-150 nm) secreted by normal and cancer cells that mediate intercellular communication. This comprehensive review examines the role of exosomal miRNAs, lncRNAs, and circRNAs in critical oncogenic processes including angiogenesis, metastasis, drug resistance, and immune modulation. Emerging evidence demonstrates that specific exosomal ncRNA contents may serve as sensitive and specific biomarkers for early detection, prognosis prediction, and monitoring of treatment response. However, challenges persist regarding standardization of exosome isolation methods and the need for expanded clinical validation. Advances in exosome research technologies hold promise for translating these findings into personalized medicine approaches. This review synthesizes current knowledge on the pathophysiological significance of exosomal ncRNAs in CRC and their clinical potential as diagnostic and therapeutic targets, while addressing existing limitations and future research directions in this rapidly evolving field.
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