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Showing 2 results for Muscle Strength
Bahman Ebrahimi-Torkamani , Marefat Siahkouhian, Ali Khazani, Anoshirvani Sajad, Bolboli Lotfali, Maryam Asadi,
Volume 20, Issue 3 (10-2020)
Abstract
Background & objectives: Over the last couple of decades, research has focused on attempting to understand the genetic influence on sports performance. Whole exome sequencing (WES) has great potential to explore all possible genetic variants associated with physical performance. However, this new technique has not been used in sports genetics research. Therefore the aim of this case study was to report new variants in genes involved in skeletal muscles strength (ACE, NOS3, IGF1R, IL-6) in an elite weightlifter using WES.
Methods: After obtaining a written testimony from a 32-year-old man, who is a member of the Iranian national weightlifting team, 5 cc of blood was taken and then DNA was extracted. DNA samples were analyzed using the whole exome sequencing method.
Results: Whole exome sequencing analysis revealed a missense variant (99454613G>A) in IGF1R, 22771156C>T polymorphism in IL-6, 150695726T>C and 150704250C>G polymorphisms in NOS3 and 61573761T>C and 61564052A>G in ACE genes.
Conclusion: Results of whole exome sequencing analysis revealed a missense variant and polymorphism in muscle strength and hypertrophy related genes in this elite weightlifter. However, other studies with larger sample sizes are needed to investigate the relationship between these variants and power athlete status.
Rezvan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Given the secretion of myokines from muscle tissue during exercise and their relationship with muscle strength development, the present study aimed to investigate the relationship between muscle strength and serum levels of irisin, brain-derived neurotrophic factor, myostatin and follistatin in inactive men and women following 12 weeks of strength training.
Methods: In this quasi-experimental study, 10 women (age: 37.6±6.09 years, weight: 80.5±20.76 kg) and 20 men (age: 39.6±6.05 years, weight: 84.89±5.67 kg) voluntarily participated. The subjects performed 12 weeks of strength training, 3 sessions per week, with an intensity of 65 to 80% of maximum strength. Blood samples were taken for measurement of irisin, brain-derived neurotrophic factor, myostatin, and follistatin by ELISA.
Results: Strength training significantly increased serum irisin, serum BDNF, follistatin and significantly decreased myostatin and fat percentage in both male and female groups (p≤0.05). There was also a positive and significant relationship between lower body strength and irisin in women (p=0.040) and upper body strength in women and BDNF (p=0.038). The results in the male group showed a significant and positive relationship between serum irisin levels with upper and lower body strength and follistatin with lower body strength (p≤0.05).
Conclusion: According to the results of the study, strength training in inactive individuals reduces serum levels of myostatin , increases secretion and serum levels of irisin, BDNF, follistatin, and increases muscle strength.
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