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Showing 2 results for Liver Enzymes
Lale Naderi , Allahyar Arabmomeni,
Volume 19, Issue 3 (10-2019)
Abstract
Background & objectives: Due to the prevalence of obesity and the subsequent development of metabolic risk factors, cardiovascular and fatty liver complications, exercise programs and the use of natural supplements can play a significant role in controlling and preventing these diseases. Therefore, the purpose of this study was to review the effect of eight weeks of combined exercise and Chlorogenic acid intake on C-reactive protein and liver enzymes in obese women.
Methods: In this quasi-experimental study, which was performed as a pre-test, post-test with a control group, a total of 48 obese women were selected purposefully and divided randomly into four equal groups (n=12); exercise, supplement, exercise+supplementation and control group. The exercises program consisted of 8 weeks of aerobic and resistance training, 3 sessions with 60 minutes per week. The chlorogenic acid supplement group received daily Green coffee in capsule form contain 400 mg powder for 8 weeks and the concurrent group performed exercise and received Green coffee simultaneously. By using blood sampling the variables were measured at baseline and after 8 weeks of intervention. Data were analyzed by t-test and ANOVA at significance level of p<0.05.
Results: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the supplement group were the lowest and in the exercise+supplementation group had the highest decrease and there was no significant difference in the control group. The C-reactive protein (CRP) in the training+supplementation group was significantly decreased and in the three experimental groups there was a significant difference compared to the control group (p≥0.05).
Conclusion: It seems that combined exercise and natural substances rich in chlorogenic acid can decrease inflammatory factors such as C-reactive protein and liver enzymes.
Hossein Kalarestaghi, Mir-Mahdi Hosseini, Ramin Salimnejad,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Liver aging is an important risk factor for chronic liver diseases. Oxidative stress is considered a common pathological mechanism for liver aging. This study aims to investigate caffeic acid's effects against liver injuries in a D-galactose-induced mouse aging model.
Methods: Forty male mice were randomly divided into 5 groups (n=8): 1) control (Con); 2) Sham; 3) caffeic acid (CA), 4) aging (Ag), and 5) aging+ caffeic acid (Ag+CA). The aging model was induced through daily intraperitoneal (i.p) injections of D-galactose (300 mg/kg) for 6 weeks. Caffeic acid (60 mg/kg, i.p.) was injected daily for 6 weeks. One day after the last injection, the mice were anesthetized, blood was withdrawn (for liver enzymes evaluation) and the liver was removed. The histopathological changes in the liver were examined using hematoxylin-eosin staining.
Results: The results showed that D-galactose-induced aging significantly increases the level of liver enzymes (AST, ALT and ALP) as well as liver tissue destruction compared to the control and sham groups (p<0.05). Treatment with caffeic acid in the Ag+CA group significantly decreased the level of liver enzymes and tissue damage index (p<0.05).
Conclusion: The results indicated that caffeic acid can reduce the destructive effects of D-galactose-induced aging in liver tissue.
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