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Showing 2 results for Irisin
Ali Abdi, Nasrin Ramezani , Mehdi Amini ,
Volume 18, Issue 1 (4-2018)
Abstract
Background & objectives: Irisin is a novel myokine that encoded by FNDC5 gene and effects on obesity, metabolism and glucose homeostasis through browning of white adipose tissue and thermogenesis. The main purpose of this study was to investigate the changes of FNDC5 gene expression and Irisin protein level of visceral fat tissue after eight weeks of resistance training in type 2 diabetic rats.
Methods: Eighteen male Wistar rats (8 week old) were used for this study. Diabetes was induced using nicotinamide and streptozotocin . Five days after inducing diabetes, rats with fasting blood glucose levels between 127-600 mg / dl were selected as diabetic subjects. Rats were homogenized according to the body weight and assigned into two groups including control-diabetes (n=9) and resistance training-diabetes (n=9). Training group exercised resistance training for eight weeks (5 days a week). The resistance training protocol consisted of climbing a one-meter- high ladder, with a weight attached to a tail sleeve. Quantitative Real time RT-PCR and ELISA Kit were used for assessment of expression level of FNDC5 gene and Irisin protein, respectively. Data were analyzed using independent t- test at p≤0.05.
Results: Resistance training significantly increased the expression level of FNDC5 gene and Irisin protein in visceral adipose tissue in type 2 diabetic rats.
Conclusion: It seems that FNDC5 gene and Irisin protein have an important role in metabolic diseases and can be affected by resistance training. Perhaps the changes in the levels of these metabolic indicators is a potential new target for the treatment of metabolic disorders, such as T2DM (type 2 diabetes).
Rezvan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Given the secretion of myokines from muscle tissue during exercise and their relationship with muscle strength development, the present study aimed to investigate the relationship between muscle strength and serum levels of irisin, brain-derived neurotrophic factor, myostatin and follistatin in inactive men and women following 12 weeks of strength training.
Methods: In this quasi-experimental study, 10 women (age: 37.6±6.09 years, weight: 80.5±20.76 kg) and 20 men (age: 39.6±6.05 years, weight: 84.89±5.67 kg) voluntarily participated. The subjects performed 12 weeks of strength training, 3 sessions per week, with an intensity of 65 to 80% of maximum strength. Blood samples were taken for measurement of irisin, brain-derived neurotrophic factor, myostatin, and follistatin by ELISA.
Results: Strength training significantly increased serum irisin, serum BDNF, follistatin and significantly decreased myostatin and fat percentage in both male and female groups (p≤0.05). There was also a positive and significant relationship between lower body strength and irisin in women (p=0.040) and upper body strength in women and BDNF (p=0.038). The results in the male group showed a significant and positive relationship between serum irisin levels with upper and lower body strength and follistatin with lower body strength (p≤0.05).
Conclusion: According to the results of the study, strength training in inactive individuals reduces serum levels of myostatin , increases secretion and serum levels of irisin, BDNF, follistatin, and increases muscle strength.
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