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Showing 1 results for Ifosfamide
Ahmad Salimi, Zhaleh Jamali, Mohammad Shabani, Deniz Bayrami, Amin Ashena Moghadam,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Ifosfamide-induced kidney damage is an important toxicity in children and adults undergoing chemotherapy. Studies have previously demonstrated that toxic metabolites of ifosfamide, such as acrolein, are associated with depletion of antioxidants, oxidative stress, and mitochondrial impairment, which may predispose the kidney to ifosfamide toxicity. Plant-derived active compounds, such as chrysin, found in fruits and vegetables, are renowned for their antioxidant and mitochondrial protective effects against toxicity-related mitochondrial damage and oxidative stress.
Methods: In this work, the protective effects of chrysin on ifosfamide-induced nephrotoxicity in male Wistar rats were investigated using biochemical, histopathological, and mitochondrial approaches. The animals were randomly divided into four groups: control, ifosfamide, ifosfamide + chrysin, and chrysin groups. Chrysin (25 mg/kg, i.p. daily) was administered to rats for 2 consecutive days, and ifosfamide (500 mg/kg, i.p.) was administered on the third day.
Results: The data demonstrated that pretreatment with chrysin significantly increased mitochondrial succinate dehydrogenase activity and protected against mitochondrial swelling, mitochondrial membrane potential loss, reactive oxygen species formation, lipid peroxidation, and glutathione depletion (p<0.001). Histopathological results showed that chrysin had protective effects and reduced histopathological abnormalities caused by ifosfamide.
Conclusion: These observations confirmed that chrysin pretreatment protects the kidneys against mitochondrial dysfunction, oxidative stress, and histopathological abnormalities induced by ifosfamide.
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