Background & Objectives: Delivery is a process with pain so one of the midwives duties is to decrease the severity of pain during delivery so decrease in labor period has been much of a concern. Atropine and Hyosine are two common drugs in decreasing time of labor and decreasing the need for labor stimulation with oxytosine. The aim of this study was to investigate the effects of hyoscine and atropine in the progress and time of labor.

 Methods:�This study was double blind clinical trial on 200 primiparous women who had labor pain and were admitted in labor in Alavi hospital in 2008. Who were randomly divided into two groups .the case group infused 20 mg Hyoscine with Atropine in the onset of active phase of labor (4cm dilation, Ruptured membrane) and in the control group 2cc, Dextrose water was infused 0.05. Then, progression in dilatation and effacement, time of active labor, time of 2^nd and 3^rd stage of labor, fetal heart rate monitoring, infant APGAR score of the 1^st and 5^th minute were registered. The data were analyzed by SPSS software using descriptive and analytical statistics as chi- square.

 Results: The findings indicated that there was a significant difference in dilatation & effacement between two groups (5/2cm/h, 1/5cm/h) (p<0.05). Duration of active phase of labor was 105 min in case group and 251 min in control group (p<0.05), duration of stage 2 was 17 min in case group and 33 min in the control group (p<0.05). Total time of labor and deliver (121 min in case group, 274 min in control group).incidence of Tachycardia and bradycardia in FHR in 30 min after infusion 25%(15% Tachycardia and 10% bradycardia in case group) 20% (12% Tachycardia and 8% bradycardia in control group) and no difference in two group was seen.

 Conclusion:�According to the finding s of this study Hyoscine and Atropine are effective in the progression of labor and delivery.

Background & objectives: Hyoscine (scopolamine) as an anticholinergic and antinociceptive drug, has some side effects. Recently, it has been received much attention to the interactions between synthetic drugs and herbal extracts and their pharmacological responses which made the possibility of using the minimum dose and low side effects. In this study, we evaluated the effect of Salvia officinale extract, hyoscine and their combinationin management of pain in rats.

Methods: In this experimental study animals were divided randomly into eight groups (n=6). Hyoscine (0.5, 1 and 5 mg/kg) administrated by intraperitoneal injection and extract (100 and 200 mg/kg) was administered by gavages one hour before administration of hyoscine. Thirty minutes after treatment, rats were subjected to tail-flick test and data were recorded. Statistical significance was considered at p<0.05.

Results: Administration of hyoscine at doses of 0.5, 1 and 5 mg/kg created significant analgesic effects compared to control group in the Tail-flick test (p<0.05, p<0.01 and p<0.05, respectively). The combination of S.officinale extract (100 and 200 mg/kg) and hyoscine (1 mg/kg) significantly increased the pain threshold than the groups receiving only extract or hyoscine.

Conclusion: Our data showed that hydroethanolic extract of Salvia officinale has an important antinociceptive effect which can lead to decreased pain in rats. Sincehyoscine as an analgesic drug has some side effects, combination of Salvia officinale extractand hyoscine can decrease the needed dose of hyoscine and itsside effects.