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Showing 11 results for Hemodialysis
Ali Reza Zahiroddin, Mortaza Hayati, Maede Jadidi, Seied Mahdi Samimi ,
Volume 5, Issue 3 (9-2005)
Abstract
Background & Objectives: Depression is the most common psychological problem in patients with End-Stage Renal Disease (ESRD). The present study was conducted to determine the rate of depression in chronic hemodialysis (HD) patients. Methods: It was a descriptive cross-sectional study. 120 chronic HD patients who referred to dialysis ward of Shahid Beheshti Medical University (SBMU) hospitals were selected through an available (non-random) sampling and after exclusion of 20 patients due to study’s exclusion criteria, all were assessed for depression, using Beck’s Depression Inventory (BDI). Statistical analyses were preformed by SPSS (rel 11.5) using analysis of variance (ANOVA), independent t-test, Chi- Square and coefficient of correlation. Results: Totally, considering the intensity of depression, 69% of patients were in depression spectrum (BDI>9), but the rate of depression was 45% (BDI >15) among chornic hemodialysis patients. There was no significant difference between the intensity of depression and various parameters, but unemployment associated with higher rate of depression (p=0.018). Conclusion:It seems the screening of HD Patients with BDI followed by referring the depressed patients to a psychiatrist for more evaluation is necessary so that at least some of the suffering, morbidity and mortality of the patients will be diminished.
Bahman Bashardoost , Hosein Doostkami , Ziba Faalpoor , Khadige Eslamnegad, Ali Abedi ,
Volume 5, Issue 4 (12-2005)
Abstract
Background & Objectives: Cardiovascular events are among the most common causes of mortality in patients with end stage renal disease. Caediac biomarkers such as troponins are very sensitive in diagnosing heart problems. Troponin I can be used to diagnose acute cardiovascular problems in hemodialysis patients. Methods: In this descriptive-analytical and cross-sectional study the level of troponin I was measured in 39 hemodialysis patients using ELISA method and BUN, Cr and Hb level before hemodialysis. LVH and LVMI were determined by echocardiography. The data were analyzed using SPSS. Results: The patients were 52.92 years old on average. 26 patients were male and 13 female. The average of tropnin I was 0.78 μ g/l. There was no meaningful relationship between troponin I and LV MI, age and sex. However, a significant relationship was found between the level of troponin I with EF and diastolic dysfunction (p=0.05). Conclusion: Troponin I can be regarded as an indicator of LV dysfunction.
Seid Kazem Shakouri , Mohammad Shimia, Vahide Toopchizadeh, Hasan Arkani ,
Volume 6, Issue 1 (4-2006)
Abstract
Background & Objectives : Although peripheral neuropathy involvement is well recognized in chronic renal failure, there are only a few studies on the evalution of central nervous system in these patients. Blink reflex as a simple and non-invasive test for evaluation of central nervous system can be helpful in patients with uremic neuropathy. Methods : This case-control and prospective study was performed on 18 patients with chronic renal failure (mean age 41.2) and 21 healthy subjects (maen age 37). Supraobital nerve stimulation was used to compare the subjects in two groups in terms of R1, IR2 and CR2 response latencies. The data were analyzed using SPSS (Ver.10). Results : Healthy subjects’ mean latencies for R1, IR2 and CR2 were 10.7, 31.9 and 33.1 milliseconds respectively. In chronic renal failure group it was 11.7, 34.3 and 35.1 millisecond respectively. The difference was statistically significant (p<0.05). Conclusion : In addition to peripheral neuropathy, cranial nerve involvement is seen in chronic renal failure. Therefore, blink reflex can be used as a simple and non-invasive method for evaluation of cranial nerve involvement.
Mohammad Mazani , Hasan Argani , Nadereh Rashtchizadeh , Mohammad Rohbaninoubar , Amir Ghorbanihagjo , Reza Mahdavi , Reza Razzaghi , Babak Rahimi Ardabily , Seyedjamal Ghaemmaghami ,
Volume 6, Issue 3 (9-2006)
Abstract
Background and Objectives: A great amount of evidence shows that Oxidative stress is high among hemodialysis patients. The purpose of present investigation is examination of the effect of zinc supplementation on improvement of oxidative stress in chronic hemodialysis patients. Methods: In this double blind clinical trial 65 chronic hemodialysis patients were studied in two groups Group one (35 patients) received placebo and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in next 2 months. Then, the study continued for two other months in the cross-over from. The levels of serum zinc, total glutathione, malondialdehyde (MDA), total serum antioxidant capacity and the activity of whole blood superoxide dismutase (SOD) were determined on 0th, 60th,120th,180th days, in fasting, predialysis samples. Food record was recorded for one day prior to dialysis in above-mentioned days and their dietary zinc was assessed. Results: Basal serum zinc levels in both groups were below 80 μ g/dl. The zinc upplementation led to significant increase in the levels of serum zinc in both groups .The levels of serum total antioxidant capacity, total glutathione and activity of whole blood SOD increased significantly during zinc supplementation period. The concentrations of serum MDA decreased significantly in zinc supplementation period in both groups. During the placebo period the levels of MDA in first group increased significantly, whereas the concentration of glutathione in second group decreased significantly. The body mass index (BMI) values did not change significantly during the study. Conclusion: It can be concluded that in patients undergoing hemodialysis the oxidative stress enhanced during nonsupplementation period (zinc sulfate). Low serum zinc levels are improved by zinc administration and zinc supplementation improves oxidative stress.
Bahman Bashardoost , Azizollah Adib , Ziba Faaalpoor , Maryam Gavami Nashr,
Volume 7, Issue 1 (4-2007)
Abstract
Background & Objectives: Hypertension is one of the major factors of cardiovascular diseases among hemodialysis patients which shoes its effect along with vascular changes. 75-80% of the patients with ESRD are hypertensive. Despite many available druge to decrease the blood pressure, many of these patients remain hypertensive. The major cause Of Hypertension is the increase in the blood volume which is due to the water and salt retention in the body. It doesn't seem that the uptake of body's fluid for a short period can have a remarkable effect on the pressure. Methods: This descriptive analytic study was done on 80 hemodialysis patients who were under trearment at Buali hospital. First patients were investigated according to age, sex, frequency of dialysis in the week and dialysis duration. These for each patient the blood pressure before and during dialysis and weight changes before and after dialysis with two consectiue sessions were measured. Calculated and MAP was determined. Finally data was analyzed through SPSS. Results: 48 out of 74 patients (64.9%) had hypertension. Blood pressure was controlled in 41 patients (55.4%). Age, sex, dialysis period and sessions of dialysis did not have a significant relationship with hypertension control. The study showed a high prevalence of high blood pressure in hemodialysis patients (64.9%). The blood pressure was not controlled in the majority of patients (44.6%). Conclusion: Patients' weight changes have no significant effect on hypertension. This shows that the causes for blood pressure can be due to other causes different from increase in the blood volume among hemodialysis patients and perhaps the chronic blood volume increase is not related to hypertension.
Seyedreza Borzou, Mahmood Golyaf, Roya Amini, Mitra Zandiha, Bita Torckman,
Volume 8, Issue 3 (9-2008)
Abstract
Background & Objectives: hyperphosphatemia and hyperkalemia have major roles of mortality and morbidity in hemodialysis patients. In this study we evaluated the effectiveness of increase in blood flow rate on blood potassium and phosphate of hemodialysis patients.
Methods: This is a clinical trial study 42 patients were assessed during the hemodialysis. A questionnaire and laboratory tests were used for gathering data. At first questionnaire of demographic data was completed and then the weight of patients was connected to each session of dialysis. Then the patient was connected to dialysis machine and blood sample was gathered before dialyzer. After taking blood sample, flow rate was regulated on 200 ml/min in the first session and on 250 ml/min in the next session. During hemodialysis, hemodynamic status and clinical status of patients was controlled. At the end of hemodialysis and before disconnection patient from dialysis machine, a blood sample was taken from arterial set before dialyzer (4 blood samples for each patient). Blood sample was sent to laboratory and all of them were analyzed by one technician and with one set.
Results: Average phosphorus changed significantly from 3.35 to 2.94 with increasing Qb from 200 to 250 similar to the increase in Qb in potassium removal (from 3.43 to 3.52) meq/lit. Paired t-test (p0.005).
Conclusion: It can be concluded so that increase in blood flow rate from 200ml/min to 250ml/min, can affect removal phosphorus but can not affect removal of potassium
Maryam Namadi , Asiyeh Movahdpoor,
Volume 9, Issue 2 (6-2009)
Abstract
Background and objectives: Quality of life is an important aspect in the evaluation of different therapeutic interventions. Quality of life assessment helps to find patients problem and revise their therapeutic method. The purpose of this study was to evaluate the life quality among patients receiving renal transplantation in comparison with hemodialysis in Ardabil university of Medical Sciences. Method: In this comparative study a total of 70 patients with renal transplantation and 93 hemodialytic patients were chosen through census sampling. An interview based questionnaire was administered for subjects to gather information on demographic characteristics and kidney disease quality of life scale. Results: Findings show that, 65.7 percent of transplanted patients reported their quality of life as good. While, in 65.6 percent of hemodialytic patients life quality was moderate. The average quality of life score in transplanted patients was 95.44 ± 12.44 SD while it was 83.53 ± 14.89 for the patients under dialyzes. The difference between the two groups were significant (p< 0/001). Conclusion: It is concluded that by transplantation, the life quality of in CRF patients may be improved.
Mohammad Mazani , Hormoz Iremlou, Hasan Argani ,
Volume 10, Issue 2 (6-2010)
Abstract
Background and Objectives: Neuropathy is a common complication in hemodialysis patients. The purpose of this investigation is examination of the effect of zinc supplementation on nerve conduction velocity in chronic hemodialysis patients. Methods: In this clinical trial 65 chronic hemodialysis patients were studied in two groups: Group one (35 patients) received 100 mg placebo (corn starch) and group two (30 patients) received 100 mg elemental zinc (as zinc sulfate) daily for 2 months. The placebo and supplement discontinued in the next 2 months. Then, the study continued for two other months in the cross-over form group one received 100 mg zinc and group two received 100 mg placebo daily for 2 months . The function of central and peripheral nerves were evaluated at the 0th, 60th, 120th, 180th days by nerve conduction velocity of electrodiagnostic test . Results: The function of nerves didn’t change significantly or some parameters markedly decreased in placebo period in both groups. Significant increase was found in the function of nerves during zinc supplementation period in both groups. Conclusion: These data indicate that zinc supplementation improve neuron function in patients undergoing hemodialysis
Reza Alipanahmogadam , Mohammad Mazani , Abbas Naghizadeh Baghi, Ali Nemati, Mojtaba Amani , Bahman Bashardoost, Amir Mansour Vatankhah , Shahab Bohlooli,
Volume 11, Issue 3 (9-2011)
Abstract
Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis . Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test. Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different. Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.
Bahman Bashardoost , Shahram Habibzadeh, Anahita Zakeri , Neda Ghaemian ,
Volume 12, Issue 5 (11-2012)
Abstract
Background & Objectives: Cardiovascular events are the most common cause of death in hemodialysis patients. Cardiac biomarkers and especially Cardiac troponin I has been used as a prognostic marker in hemodialysis patients and there is some controversies about its value. For these reasons this study has been done for evaluation of prognostic value of Troponin I and left Ventricular Hypertrophy in mortality of hemodialysis patients. Methods:This is a prospective descriptive-analytic study, has been done from 2006 -2011 All of new cases whom entered to dialysis center in 2006 studied with measurement of base line Cardiac Troponin I and left ventricular mass index .Patients fallowed up 5 years later without any specific intervention and survival rate was calculated crudely and in base of Cardiac Troponin I and left ventricular mass index separately after exclusion of non cardiac deaths. Results:76 patients followed up 5 years and 35 of them died. Mean age of patients was 57.4 ± 15.6 year. Mean Troponin I (cTnI) in dead patients was 0.92±0.68ng/l and in alive patients was 0.78±0.58ng/l (p=0.39). Mean Left Ventricular Mass in dead patients was 274.9±100.8 g/m2 and in alive patients was 249±77.7 g/m2 (p=0.23). A significant linear correlation was not founds between cTnI level and Left Ventricular Mass Age was the most important cofactor of death. Conclusion: Significant correlation was not founded between cTnI level and Left Ventricular Mass with cardiac mortality .mortality. This may be due to some other factors such as age, quality of control of hypertension and other coexisted diseases, quality of life and home cares. Age had more important effect on death and this may reflect multiplicity of heath related problems in them.
Seyed Javad Kia, Ali Khalighi Sigaroudi , Bardia Vadiati Saberi , Abolfazl Bagheri ,
Volume 14, Issue 2 (7-2014)
Abstract
Background & Objectives: Chronic renal failure (CRF), also known as chronic kidney disease, caused by devastated nephron mass of the kidney results in uremia. Hypertension, diabetes mellitus and glomerulonephritis are common etiologic factors of CRF. This condition causes miscellaneous oral manifestations especially in diabetic patients. The aim of this study was to comparison oral manifestations of diabetic and non-diabetic uremic patients undergoing hemodialysis. Methods: A total of 95 patients who undergoing hemodialysis in Razi hospital in Rasht city participated in this descriptive analytical study. Patients were divided into two diabetic and non- diabetic groups. Oral cavity examinations were done by latex gloves and single use mirror. Objective and subjective oral manifestations such as xerostomia, bad taste, mucosal pain, uremic odor, coating tongue, petechial, purpura, pale oral mucosa, ulcer, dental erosion and candida infection were recorded in questionnaire. After gathering of information, the data were analyzed by SPSS 15 software using t-test and chi square statistical test. Results: About 60% of patients (57 person) were men and 40 % (38 person) were women. The mean age of patients was 48 years (range of 20 -76 years). Common subjective oral manifestation in both groups was xerostomia and most common objective oral manifestations were pale oral mucosa, uremic odor and coating tongue respectively. The DMFT index in diabetic group was significantly higher (17.3±7.63) than non-diabetic patients (12.4±8.26). There was no significant statistical correlation between the time of dialysis, number of dialysis appointment during the week and objective and subjective oral manifestations in two groups. Conclusion: Although, the present study has shown an increase in oral manifestations in diabetic patients undergoing hemodialysis relative to non-diabetic group, but this increase was not statistically significant. On the other hand results of our study have indicated significantly higher DMFT in diabetic group in comparison with the non-diabetic group. So patients with diabetes mellitus undergoing hemodialysis need to more oral and dental health care.
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