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Background & Objectives: In addition to the socio-economics costs, Diabetes is a major cause of illness and death at all groups. Diabetes affects over %10 of adults in the world. Despite promising trend in improving many aspects of health Care and treatment in the last decade in our country, little attention has been paid to the subject of registering Diabetes on an international standard. Quality improvement of treatment, identifying high risk groups, controlling, preventing and evaluating of diabetes, would materialize only when the national Diabetes Registry System is established and its data are collected and completed on time. The aim of this study was to suggest Diabetes registry system in Iran, to meet the health and medical needs.

Methods: This Comparative Cross-sectional study was conducted to evaluate the developed national diabetes registry systems in 2003. In this study national diabetes registry system in Britain and USA was evaluated by library resources, Websites and Email communication with internal and external specialist. Suggestions were made on the basis of economic cultural and geographic situations. These axes included aims, structures, data elements, registration, data collection processing, and classification and control of quality of system.

Results: The results show that in order to optimize the diabetes registry system, structure, data elements, information gathering process, main goals, registration criteria, Classification systems and quality control mechanism of the current national diabetes registry system should be reevaluated.

Conclusion: Considering the results and international diabetes institutes recommendation, the decrease in poor registry and increase in quality can be the advantages of model suggestion in comparison with the country's current system.

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  Background & Objective: Mortality statistics and cause of death are the main components in health planning in any community. Knowry the change of marraliy pattern is important for future health programming. This study have to determine and analyze the Mortality changing trends dury lest 35 years.

  Methods: In this study data recorded of 9740556 deaths from were analyzed. Graphical method were usead to analyze dara and . We analyzed data by croghal method and comping the trouds of morality cheye pattern.

  Results: Our servey should 60.4% of total deaths were in rural areas and 61.1% among males. The crude death rate was 13per 1000 pasim from to 1971-76 that decrease to 5 per 1000 pasim from to 2006-2010. Also life expectancy rate has been increased in study years from 55.2 in 1971-76 to 71 in 206-2010.

  Conclusion: results show that mortality pattern in years 1970 to 2007 have been changed and crude death rate with decrease tread and life expectancy with increase trend represent the level of health indicators in world and our country Iran have been developed and extended.

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Background & objectives: Coronary artery disease (CAD) is the most common cause of mortality and disability around the world. Determination of the health status and spatial and temporal patterns of the disease prevalence has a major role in health planning.
This study aimed to investigate the spatiotemporal pattern of CAD in Ardabil Province.
Methods: This descriptive and cross-sectional study was performed using the data belonging to 60156 patients with history of hospital admission due to CAD in Ardabil Province during 2010-2015. Hospitalization Rate (HR) was calculated after classification of the data in terms of location and date of hospitalization. The spatiotemporal and demographic variables, including age, gender, type of CAD, periods and duration of hospitalization were analyzed by descriptive statistics, ANOVA and repeated measures in SPSS v23 statistical software. Spatial distribution maps were drawn for each month and year in ArcGIS 10.2.
Results: Of 60156 hospitalized patients with CAD diagnosis, men (58%) were more in number than women (42%). The majority of hospitalized patients fell in the age range 60-69 years (25.3%), and 92.40% of patients were hospitalized for less than 7 days. An ascending pattern was observed in temporal hospitalization trend in Khalkhal and a descending trend in Ardabil. The lowest hospitalization rate, however, was observed in Kosar city despite the ascending trend. During the research period, the greatest decline in hospitalization rate was observed in temporal trend in Bilasuvar, Meshkinshahrand Namin cities, and the largest increase was observed in Germi, Pars-Abad and Kosar cities.
Conclusion: By using the comprehensive technology, GIS, spatiotemporal distribution and CAD trend during 2011-2015 were modeled in Ardabil province. Spatiotemporal trend of CAD in Ardabil province and allied cities indicated the necessity of paying more attention and studying community for further prevention of the disease. Community-based interventions should be implemented for prevention of risk factors of CAD during childhood and adolescence especially in the districts with high risk.

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Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- intoxicated rats.
 Methods: In this experimental study, forty-two male Wistar rats were divided into 7 groups (n=6). Three control groups including normal control, combined extract control and damaged control were designated that received distilled water, a mixture of cinnamon and ginger extracts and distilled water respectively for 14 days.
 Other 4 groups were pre-treatment  groups which were treated with cinnamon (50 mg/kg/d), ginger (250 mg/kg/d), cinnamon + ginger (25+125 mg/kg/d) and silymarin (100 mg/kg/d) respectively for 14 days before being damaged by intraperitoneal injection of CCl₄ (1 ml/kg, 1:1 in olive oil). Fifty - two hours after CCl4 injection, blood sampling was performed and biochemical parameters were measured in serum of rats.
Results: The results of this study showed that the injection of CCl₄ significantly increased the ALT and AST enzymes activity ,cholesterol, triglyceride, and LDL levels and decreased the blood albumin and HDL levels in damaged rats compared to the normal control group (p<0.001). However, pre-treatment with the cinnamon and ginger extracts, especially combination of extracts significantly improved these values ​​compared to the CCl₄ damage group (p<0.001).
Conclusion: The results suggest that simultaneous use of cinnamon and ginger extracts has more significant protective effects against CCl₄-induced hepatotoxicity.