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  Background & Objectives: Acne vulgaris is a chronic inflammation of pilosebaceous units. In sever forms it may lead to major scars on the face and trunk, and significant face and trunk scarring, and psychological disorders. Antiandrogen therapy can be used as a suitable and effective remedy for female acne. Furthermore, they can treat, accompanying androgenic problems. Also, there is no under consideration drug resistance against androgens. The aim of this study is to compare the therapeutic effects of flutamide and doxycycline in moderate acne in females .

  Methods: This current study is a randomized and blind evaluation trial. 62 female patients participated at this study. They were divided in two groups (case and control). Case group was received 250 mg/day flutamide, control group 100 mg/day doycycline. Both groups also received topical solution of clindamicin 1% twice daily. The length of study was six months .

  At first visit and the end of the second month of study liver function were tested for the case group patients. Evaluation of resolution in lesions was performed by another physician every two months of therapy. The probable side effects of drugs were recorded. Data were analyzed with SPSS16 software using statistical tests and p ≤ 0.05 considered as significant

  Results: The mean of patients age was 19.27 ± 3.55 years, and the difference was not found to be statistically significant in two groups. Number of comdeons on face was found to be statistically decreased in flutamide group (p<0.0001). Mean of ASI was found to be statistically decreased in flutamide group (p<0.002). In flutamide group the levels of satisfaction was higher than that of other group. Both medications well tolerated by participiants. Only two patients in flutamide group had lightly elevated serum Alkalin phosphatase .

  Conclusion: The results of our study showed that flutamide (250 mg /day) is more effective than doxycycline (100 mg/day) in treatment of acne. Satisfaction of participants in flutamide group was higher than those in doxycycline group. In both groups side effects of drugs were insignificant, but using of flutamide in acne treatment needs laboratory considerations .

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Background & objectives: In recent years, the hypothesis of using anti-androgens has been increasingly addressed in the treatment of acne in women. One of these drugs is flutamide, which there is no strong evidence of its efficacy in treatment of acne in women. The aim of this study was to compare the effect of combination therapy of flutamide-cyproterone compound with flutamide-doxycycline in severe type of acne in women.
Methods: In an interventional study, patients were divided in to two groups. One group (n=30) received flutamide - cyproterone compound and another group (n=30) received flutamide-doxycycline which were followed for six months. Both groups also received 1% topical clindamycin twice a day. Counting the number of lesions, changes in severity index and grading of acne were used to evaluate the patients. Patient satisfaction was also evaluated.
Results: The mean age in the flutamide-doxycycline group was 19.4±4.67 and in the flutamide-cyproterone compound group was 19.06±11.3. This difference was not statistically significant. The mean of the acne severity index at the onset of intervention between the two groups was not significant (p= 0.7). The mean of the acne severity index at the start of treatment in the flutamide-doxycycline group was 306.07±155.46 and at the end of treatment reached to 19.18±19.5, and also in the flutamide-cyproterone compound group, decreased from 293.21±15.21 to 10.5±21.8 at the end of treatment. This difference was not statistically significant (p=0.1).
Conclusion: Both therapeutic regimen were effective in the treatment of severe type of acne and can possibly be used as an alternative treatment for severe acne.

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Background & objectives: Acne is a chronic inflammation of pilosebaceous units and in severe form reflects a different response to treatment in an oral regime of antibiotics. The purpose of this study is to compare the effect of the combination of erythromycin and low dose oral isotretinoin with erythromycin and low dose flutamide in women suffering from severe acne.
Methods: In a randomized controlled clinical trial, 80 women suffering from severe acne participated in the study and they were studied for 2 months. The first group received 800 mg oral erythromycin, together with 20 mg oral isotretinoin every two days and the second group received 800 mg erythromycin, together with 62.5 mg flutamide daily. The treatment efficiency was evaluated by the count of acne lesions and computing the acne severity index. The data of the study were analyzed using the version 16 of spss software.
Results: In the present study, 40 patients participated in the research in each group. Finally, 61 people completed the study. The mean acne severity index in the flutamide group was 195.9±15 at the beginning of treatment and this index reduced to 52.8±5.8 at the end of treatment. The mean acne severity index in the isotretinoin group was 247.8±19.7 at the beginning of treatment and this index reduced to 76.3±12.5 at the end of treatment. The difference in reduction between the two groups was not statistically significant (p=0.15).
Conclusion: The treatment effectiveness of the above-mentioned methods in female severe acne was acceptable and this combination therapy can be presented as a better alternative compared to treatments with high dose individual treatment including oral isotretinoin and oral flutamide.