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Showing 2 results for Fluorouracil
Mahshid Khajavi, Elham Safarzadeh, Faraz Mahdizadeh, Shokofeh Banaei,
Volume 0, Issue 0 (4-2024)
Abstract
Background: 5-fluorouracil is one of the chemotherapy drugs that has destructive effects on body tissues such as the heart, liver, kidney, brain and reproductive system in humans and animals. Reproductive dysfunction is considered to be an important side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the effects of Oleuropein (OLE) against 5-FU-induced ovarian toxicity.
Methods: 24 adult female rats (weighing 200-225 g) were randomly divided into 4 groups (N= 6) with a treatment period of 14 days including the control group, 5-FU (100 mg/kg/week, IP), OLE (200 mg/kg/day, IP), 5-FU + OLE group, administrated 5-FU (100 mg/kg/week) with OLE (200 mg/kg/day). After treatment, blood samples were collected for the measurement of female sexual hormones, and ovarian samples were taken for histological assessment.
Results: 5-FU significantly decreased female sexual hormones. Also, it caused tissue damage in the ovary, as 5-FU-administered rats had degenerated follicles and hemorrhage. While the administration of OLE significantly increased the estradiol, and progesterone (p< 0.05) levels and improved ovarian pathological changes.
Conclusion: Oleuropein reduces 5-fluorouracil –induced reproductive toxicity in female rats.
Eiraj Sayadrezai, Majid Rostami,
Volume 8, Issue 3 (9-2008)
Abstract
Background & objectives: Warts are common dermatological disorder which are difficult to treat and usually relapse. In this study the efficacy of topical %5 5- fluorouracil was compared with conventional cryotherapy in treatment of plantar Warts. Methods: In a clinical trial study, 50 patients clinically diagnosed as warts were divided in to two groups. 25 patients were treated with topical 5% 5- fluorouracil while the other 25 were treated with cryotherapy. After treatment, patients were followed for 6 months from the viewpoints of treatment complication, efficacy and relapse rate. Results: It was observed that treating period in cryotherapy was short but 5F-U therapy needed longer time. Initially in 5-FU group 52% of patient had good response, 36%moderate response and in 12% no response was observed there is no significant difference in view of sex in this group (p=51%) and in cryotherapy group 60% of patients had good response, 28% moderate response and in 12% no response was observed like wise there was no significant difference in terms of gender (p=0.08). In response to therapy there was no difference between two groups (p=0.09%) after 6 months follow up relapse rate was 18% in cryotherapy patients and only 8%in 5-FU group which wasn't statistically meaningful and no difference was observed between two groups (p=0.27). Conclusion: The results indicated that course of treatment was shorter in cryotherapy than the topical 5- FU but the relapse rate didn't have any difference between two groups. The only significant difference was pain in which 5- FU was painless but cryotherapy was painful.
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