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Showing 2 results for Exosome
Melika Izadpanah,
Volume 24, Issue 2 (7-2024)
Abstract
Endometriosis is a long-term health condition that is known as a significant factor in women's infertility issues nowadays. Since many factors contribute to the development of this disease and because diagnosis is difficult and typically happens late in the progression of the disease, early detection is especially crucial. Extracellular micro vesicles called exosomes have diverse biological molecules and can alter the behavior of recipient cells, influencing angiogenesis, fibrosis, and inflammation. Exosomes are significant in cell communication and could act as new biomarkers for early detection of endometriosis. Hence, exploring and comprehending the impact of exosomes on the development of endometriosis can create opportunities for studying potential diagnostic biomarkers and targeted therapeutic interventions to prevent the advancement of the condition. This article delves into new approaches to diagnose and treat endometrial disorders by highlighting the various functions of exosomes in endometriosis.
Parham Mansouri, Dariush Shanehbandi,
Volume 25, Issue 2 (7-2025)
Abstract
Colorectal cancer (CRC) remains one of the most prevalent gastrointestinal malignancies, posing significant challenges in diagnosis and treatment. Recent research has highlighted exosomes and their non-coding RNA (ncRNA) cargo as key players in tumor progression and novel diagnostic tools. Exosomes are extracellular vesicles (50-150 nm) secreted by normal and cancer cells that mediate intercellular communication. This comprehensive review examines the role of exosomal miRNAs, lncRNAs, and circRNAs in critical oncogenic processes including angiogenesis, metastasis, drug resistance, and immune modulation. Emerging evidence demonstrates that specific exosomal ncRNA contents may serve as sensitive and specific biomarkers for early detection, prognosis prediction, and monitoring of treatment response. However, challenges persist regarding standardization of exosome isolation methods and the need for expanded clinical validation. Advances in exosome research technologies hold promise for translating these findings into personalized medicine approaches. This review synthesizes current knowledge on the pathophysiological significance of exosomal ncRNAs in CRC and their clinical potential as diagnostic and therapeutic targets, while addressing existing limitations and future research directions in this rapidly evolving field.
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