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Showing 2 results for E. Coli
Parviz Mohajeri , Babak Izadi , Mansour Rezai , Badie Falahi , Hosna Khademi , Roya Ebrahimi ,
Volume 11, Issue 1 (4-2011)
Abstract
Background & Objectives: Nowadays, appearance of ESBL producing bacteria is medical problem in the treatment of infections. Uropathogenic Escherichia coli like many other bacteria can produce these types of enzymes. T he assessment of the ESBL production by clinical isolates is not done routinely in laboratories. The aim of this study was to determine the prevalence of ESBL producing E.coli and its antibiotic resistance pattern in Kermanshah. Methods: This cross - sectional study was done on 200 Uropathogenic E. coli strains isolated from people in Kermanshah. Sensitivity of isolates to different antibiotics was determined by disk diffusion test and ESBL production was assessed by DDST method. Results: The E. coli strains showed high susceptibility to imipenem (100%), amikacin (97%), nitrofurantoin (95.5%), gentamicin (85%), cefepime (75%), ceftazidime (74%), ofloxacin (73.5%), ciprofloxacin, ceftriaxone and aztreonam (71%) and cefotaxime (70%) respectively. The highest resistance was seen to ampicillin (77%), carbenicillin (76%), pipracillin (74%) and SXT (62.5% ). Resistance rate to third generation cephalosporins was 63-75%. Fifty seven isolates (27%) were ESBL producers and 47 isolates (87%) produced all four types of ESBL enzymes. Conclusion: There are some similarities and differences in the antibiotic resistance pattern and ESBL production among the isolates in different areas of Iran and other countries. Identification of ESBL producing bacteria and determining its antimicrobial resistance pattern are recommended to effective treatment of infections.
Khadijeh Hamidian, Elyas Abdollahi, Zahra Yazdanpour, Laleh Shahrakimojahed, Farzad Khademi, Hamid Vaez,
Volume 21, Issue 1 (4-2021)
Abstract
Background and objectives: Urinary tract infection (UTI) is the most prevalent infection and Escherichia coli (E. coli) is one of the main causes of UTI worldwide. Integrons are mobile genetic elements considered to be responsible for dissemination of multi-drug resistance infections. Therefore, the aims of this study were to investigate the antibiotic resistance patterns and distribution of class I, II and III integrons among E. coli isolated from patients.
Methods: In this descriptive cross-sectional study, from Jun 2020 to March 2021, in total, 70 non-duplicate strains of E. coli were isolated from patients with UTI referred to Amiralmomenin hospital, Zabol, Iran. Antibiotic resistance patterns were determined using Kirby-Bauer’s disk diffusion method and Clinical and Laboratory Standards Institute (CLSI) guidelines. Class I, II and III integrons were detected using polymerase chain reaction (PCR).
Results: The isolates showed high resistance toward ampicillin (77.1%), trimethoprim- sulfamethoxazole (58.5%) and ceftriaxone (35%), whereas were mostly susceptible to meropenem (97%). Based on results of PCR, 34 (48.6%) and 3 (4.3%) isolates were classified as class I and class II integron-positive strains, respectively.
Conclusion: Resistance rate to ampicillin, ceftriaxone and trimethoprim-sulfamethoxazole was at a high level and their prescription should be restricted. Class I integron is widely distributed among E. coli isolates and play a crucial role in the emergence of antibiotic resistance
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