|
|
|
|
|
 |
Search published articles |
 |
|
Showing 3 results for Combination Therapy
Hosein Dostkamy, Raeouf Mollajavad , Ahad Azami ,
Volume 7, Issue 2 (6-2007)
Abstract
Background & objectives: Hypertension is a disease with high prevalence and complications and unfortunately the freatment of which is not desirable in many communities including ours. The aim of this study is to assess the therapeutic diet giving and level control of HTN in patients with Hypertension who refered to Ardabil Boali Hospital emergency room and out patient Clinic room. Methods: This study was performed on 200 patients who refered to the emergency room and out patient Clinic in Ardabil Boali Hospital from 2003 to 2004 due to high blood pressure. In this study, blood pressure and other factors such as sex, age and the therapeutic modality including compliance to theyapy and kind and quality of drugs were determined, then the data was analyzed by using descriptive statistics. Results: Of 200 patients only 1% did not take drug 59.5% of patients were on monotherapy and 39.5% took two or more drugs 33.5% were on Beta blocker (Atenolol) and 11% on ACE inhibitor (Enalapril). Among patients on combination therapy the highest prevalence was B.bloche and ACE.I 40%, and the least one prevalence was diuretic and CCB (2%). All patients on diuretic were pre hypertensive whereas the majority of patients on CCB had stageII hypertension. In patients on multi drug therapy all patients on diuretics + CCB were pre hypertensive but 57% of patients on ACEI + CCB or ACE.I + diuretic had stageII hypertension. Conclusion: In this study for combination therapy Diuretic and CCB had the best result in controlling hypertension.
Hasan Edalatkhah, Zahra Bironbar Fathi , Negar Khoshnevis , Saeid Sadeghieh Ahari ,
Volume 18, Issue 2 (7-2018)
Abstract
Background & objectives: In recent years, the hypothesis of using anti-androgens has been increasingly addressed in the treatment of acne in women. One of these drugs is flutamide, which there is no strong evidence of its efficacy in treatment of acne in women. The aim of this study was to compare the effect of combination therapy of flutamide-cyproterone compound with flutamide-doxycycline in severe type of acne in women.
Methods: In an interventional study, patients were divided in to two groups. One group (n=30) received flutamide - cyproterone compound and another group (n=30) received flutamide-doxycycline which were followed for six months. Both groups also received 1% topical clindamycin twice a day. Counting the number of lesions, changes in severity index and grading of acne were used to evaluate the patients. Patient satisfaction was also evaluated.
Results: The mean age in the flutamide-doxycycline group was 19.4±4.67 and in the flutamide-cyproterone compound group was 19.06±11.3. This difference was not statistically significant. The mean of the acne severity index at the onset of intervention between the two groups was not significant (p= 0.7). The mean of the acne severity index at the start of treatment in the flutamide-doxycycline group was 306.07±155.46 and at the end of treatment reached to 19.18±19.5, and also in the flutamide-cyproterone compound group, decreased from 293.21±15.21 to 10.5±21.8 at the end of treatment. This difference was not statistically significant (p=0.1).
Conclusion: Both therapeutic regimen were effective in the treatment of severe type of acne and can possibly be used as an alternative treatment for severe acne.
Hassan Adalatkhah, Saeed Sadeghieh Ahari , Safa Mosavi,
Volume 21, Issue 3 (10-2021)
Abstract
Background & objectives: Acne is a chronic inflammation of pilosebaceous units and in severe form reflects a different response to treatment in an oral regime of antibiotics. The purpose of this study is to compare the effect of the combination of erythromycin and low dose oral isotretinoin with erythromycin and low dose flutamide in women suffering from severe acne.
Methods: In a randomized controlled clinical trial, 80 women suffering from severe acne participated in the study and they were studied for 2 months. The first group received 800 mg oral erythromycin, together with 20 mg oral isotretinoin every two days and the second group received 800 mg erythromycin, together with 62.5 mg flutamide daily. The treatment efficiency was evaluated by the count of acne lesions and computing the acne severity index. The data of the study were analyzed using the version 16 of spss software.
Results: In the present study, 40 patients participated in the research in each group. Finally, 61 people completed the study. The mean acne severity index in the flutamide group was 195.9±15 at the beginning of treatment and this index reduced to 52.8±5.8 at the end of treatment. The mean acne severity index in the isotretinoin group was 247.8±19.7 at the beginning of treatment and this index reduced to 76.3±12.5 at the end of treatment. The difference in reduction between the two groups was not statistically significant (p=0.15).
Conclusion: The treatment effectiveness of the above-mentioned methods in female severe acne was acceptable and this combination therapy can be presented as a better alternative compared to treatments with high dose individual treatment including oral isotretinoin and oral flutamide.
|
|
|
|
|
|
|
|
|
.png)
.png)
