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Showing 1 results for Cerebellum
Kaveh Samadi, Ramin Salimnejad, Mohammad Jannat Dost, Behnam Ahadi, Zeinab Namjoo,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Curcumin is the main and active compound of turmeric and a yellow phenolic pigment that has antioxidant and anti-inflammatory properties. This study aimed to investigate the effect of curcumin on the morphology of cerebellar Purkinje neurons in rats with spinal cord injury.
Methods: In this experimental study, 9 rats were randomly divided into 3 groups: 1) spinal cord injury (SCI); 2) laminectomy; and 3) spinal cord injury+curcumin (SCI+curcumin). Spinal cord injury was induced by compression at the T10 segment of the spinal cord by placing a 50-gram weight for 5 minutes. In the treatment group, curcumin was administered at a dose of 100 mg/kg daily for 8 weeks by gavage. At the end of the 8th week, the BBB motor test was performed on the rats in all three groups, and after euthanasia, their cerebellum was removed and stained with hematoxylin and eosin. Finally, the tissue organization of the molecular, Purkinje, and granular layers and the tissue damage index were analyzed histologically.
Results: The results of our study showed that the morphology of cerebellar Purkinje cells changes after spinal cord injury, but treatment with curcumin can reduce the destruction of these cells and maintain their typical morphological characteristics.
Conclusion: Based on the present study, curcumin can reduce the destruction of cerebellar Purkinje neurons in rats with spinal cord injury and also lead to motor improvement in these animals.
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