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Showing 2 results for Ctx
Faezeh Gholam Ali Khamseh, Allahyar Arabmomeni,
Volume 0, Issue 0 (4-2024)
Abstract
Background: Physical activity combined with mineral supplementation has been reported to enhance bone mineral density and improve bone health after menopause. Accordingly, the present study aimed to investigate the effects of BodyPump training in combination with calcium and vitamin D supplementation on bone health biomarkers in postmenopausal women.
Methods: In this quasi-experimental study with a pretest-posttest placebo-controlled design, 45 postmenopausal women from Isfahan, aged 55-65 years with a body mass index (BMI) of 24±3 kg/m², were purposively selected and randomly assigned to three groups: BodyPump training, BodyPump training plus calcium and vitamin D supplementation, and placebo. The exercise protocol was conducted for eight weeks, three sessions per week, lasting 40-60 minutes per session with 10% One-Repetition Maximum. In addition, participants in the BodyPump+supplementation group consumed two calcium+vitamin D tablets daily for eight weeks. Data were analyzed using multivariate analysis of covariance (MANCOVA) followed by Bonferroni post hoc tests.
Results: A significant increase in bone-specific alkaline phosphatase (BSAP) was observed in both the BodyPump and BodyPump+supplementation groups (p≤0.001). Moreover, a significant reduction in the C-terminal telopeptide of type I collagen (CTX) was found in both intervention groups (p≤0.002). Notably, the changes in these biomarkers were significantly greater in the BodyPump+ calcium and vitamin D supplementation group compared to exercise alone.
Conclusion: These findings suggest that BodyPump training combined with calcium and vitamin D supplementation has beneficial effects on bone health biomarkers in postmenopausal women. Therefore, the combined use of exercise and supplementation may be a valuable strategy to improve bone health outcomes in this population.
Hoosna Sarvazad, Mojtaba Darbouy,
Volume 17, Issue 3 (10-2017)
Abstract
Background & objectives: One of the main problems in the control of nosocomial infections due to Klebsiella pneumoniae is increase of antimicrobial resistance and prevalence of extended spectrum β-lactamase (ESBLs) producing isolates. The aim of this study was to investigate the correlation of antibiotics resistance with SHV, CTX-M and TEM extended-spectrum beta lactamases genes among Klebsiella pneumoniae isolates isolated from the patients in Kermanshah hospital.
Methods: The clinical isolates of Klebsiella pneumoniae were collected during the spring from Kermanshah hospitals, and identification of Klebsiella pneumoniae strains was performed using standard microbiological and biochemical tests. Antibiotic resistance of Klebsiella pneumoniae isolates was determined using disk diffusion method. Then, the presence of CTX-M, SHV, and TEM was investigated using multiplex-PCR method. Finally, the relationship between variables was analyzed by SPSS-22 software using logistic regression and chi-square.
Results: A total of 98 isolates out of 112 samples were identified as Klebsiella pneumonia. Also, 82.8% of isolates were resistant to cefotaxime, 40.2% to ceftriaxone, 62.88% to ceftazidime, 3.9% to imipenem, 39.17% to cefepime, 64.94% to cefixime and 26.8% to amikacin. Further, 35.55% of isolates had CTX-M gene, 63.91% of isolates had SHV gene and 9.27% of samples had TEM gene.
Conclusion: The presence of CTX-M, SHV and TEM genes along with high antibiotic resistance are very concerning, indicating the importance of rational use of antibiotic for the treatment of infectious diseases.
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