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Showing 5 results for Blood Glucose
Hosein Khadem Haghighian , Alireza Farsad Naimi, Bahram Pourghassem Gargari , Akbar Ali-Asgharzadeh , Ali Nemati ,
Volume 10, Issue 4 (12-2010)
Abstract
Background & Objectives: Different types of diets and several chemical and herbal drugs are used for decreasing the fasting blood glucose, glycosylated hemoglobin and insulin resistance in type II diabetic patients. New herbal medicines including cinnamon have been considered for controlling diabetes. Since few reports have been presented in other countries and many studies have been done in animal models in laboratory condition, this study was aimed to investigate cinnamon supplementation effects on fasting blood glucose, glycosylated hemoglobin and insulin resistance among type II diabetic patients . Methods: In a clinical trial study, 60 male and female patients with type II diabetes mellitus (30 patients in control and 30 patients in treatment group) were selected in Tabriz city, during 1388. The intervention group received 1.5 g of cinnamon (as a capsule containing 500 mg powder, three times daily) for 60 days and control group received placebo. Blood samples obtained from patients to determine the levels of fasting blood glucose, the glycosylated hemoglobin and insulin, before and after cinnamon consumption. Insulin resistance was measured by HOMA score and data were expressed as Mean ± SD and analyzed statistically by Student t-test. p<0.05 was considered as significant . Results: After 60 days, the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance decreased significantly in the intervention group compared to controls (p<0.05). There was no significant change in the fasting blood glucose levels, the glycosylated hemoglobin and the insulin resistance in the control group at the end of 60 days. Conclusion: This study showed the consumption of cinnamon can be useful in the fasting blood glucose, the glycosylated hemoglobin and the insulin resistance control among type II diabetic patients .
Sima Nasri, Mahmood Abedinzade, Masoumeh Jamal Omidi, Farzad Noursabaghi ,
Volume 13, Issue 1 (4-2013)
Abstract
Background & Objectives: Diabetes mellitus is recognized with severe metabolic complications. Many herbal medicines have been recommended for treatment of diabetes. In this study, the antidiabetic and analgesic effect of hexanic and alcohlic extract Trigonella-foenum graecum was investigated in normal and streptozotocin-induced diabetic rats. Methods: Present study was carried out in 2011 at Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gr) were divided into six groups: control, type 1 diabetic, and 4 treat ed groups that received intraperitonealy hexanic and alcoholic extract of fenugreek (100, 200 mg/kg body weight) for 28 days. Two experimental models were used (acetic acid, and hot-plate tests) in order to characterize the analgesic effect. Blood glucose was measured with glucometer. Data analyzed with spss software 16 and one way ANOVA and Tukey tests. P<0.05 was statistically significant. Results: Compared to control rats, both of the aqueous - alcoholic and Hexan ic extract significantly reduced blood glucose level in all diabetics groups. This effect was stronger in groups that received Hexanic extract (p<0.05) . All groups received the aqueous - alcoholic and Hexan ic extract showed analgesic effect but this effect was more clear in the Hexanic 200 mg/kg group (p<0.05). Conclusion: Fenugreek extract possesses hypoglycemic , and analgesic effects .
Fahimeh Esfarjani, Fatemeh Rashidi, Seyied Mohammad Marandi,
Volume 13, Issue 2 (7-2013)
Abstract
Background & Objectives: Elevated apolipoprotein B-100 and decreased Plasma HDL due to hypertriglyceridemia are common abnormalities in insulin-resistant subjects that increase the risk of cardiovascular disease. The aim of this study was to investigate the effects of 8 weeks progressive aerobic exercise (AE) on blood glucose, lipidand lipoprotein profile, and aerobic power in adults with type 2 diabetes. Methods: Twenty nine women with type 2 diabetes (mean age 43.4 ± 1.7 years and blood glucose range of 150 to 230 mg/dl ) were divided into a control (n=14) and exercise (n=15) groups. Exercise group participated in an aerobic training program 3 times per week for 8 weeks. The intensity of aerobic exercise was 60–75% of HR max. The control subjects were asked not to alter their physical activity patterns. All subjects underwent anthropometric, lipid profile and aerobic power evaluation, at the baseline and 48 hours after last session training. Following a 12 h overnight fasting, a venous blood sample was drawn for the analysis of total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low-density lipoprotein (LDL), and (apoB100). Paired t test and analysis of covariance (ANCOVA) were used to analyze the data. Results: Significant improvement was observed in FBS, aerobic power, percent body fat, (Apo) B-100 and triglycerides (p< 0.05) for the exercise compared with the control group after training. No significant difference was observed in TC, LDL and HDL between two groups. Conclusion: According to our findings moderate intensity physical exercise can be effective in preventing the atherosclerosis via significant improvement in blood sugar, cardiovascular endurance, Apo B-100 and triglyceride in patients with type 2 diabetes.
Majid Mobasseri, Armin Sadeghi, Alireza Ostadrahimi, Samira Pourmoradian,
Volume 13, Issue 4 (1-2013)
Abstract
Background: Obese patients are at high risk of numerous chronic diseases including diabetes, hypertension, heart disease, dyslipidemia and stroke. Recently researchers focused on complementary medicine along with routine treatments to reduce obesity complications. Therefore we aimed to investigate the effects of omega 3 fatty acids supplementation on serum lipid profiles, C-peptide and fasting blood glucose in obese individuals. Methods: In this randomized clinical trial 56 obese volunteers with the mean age of 33.94±8.15 years were assigned into the supplemented (n=30) and placebo (n=26) groups, given two omega 3 fatty acids soft gel (360 mg EPA and 240 DHA) or placebo respectively for 4 weeks. At the onset and the end of the intervention, blood samples were collected after overnight fasting and serum lipid profiles, C-peptide and fasting blood glucose were measured. Data were analyzed with SPSS program and p-value less than 0.05 considered as significant. Results: In comparison with placebo group, omega 3 supplementation resulted in a significant decrease in the mean triglyceride (108.37±11.22 mg/dl vs 148.84±59.40 mg/dl). After 4 weeks, the mean C-peptide concentrations increased in both groups but elevation in omega 3 group was more dramatic (p<0.01). However, we didn’t find any significant changes in the mean total cholesterol, LDL-C and HDL-C levels. Conclusion: Our finding indicated that 4 weeks Omega 3 supplementation leads to amelioration in some of serum lipid profiles indices and insulin secretion in obese individuals. Although, further studies are needed to achieve precise results.
Mehdi Faramoushi, Ramin Amir Sasan , Sari Sarraf Vahid, Pouran Karimi,
Volume 16, Issue 1 (4-2016)
Abstract
Background & objectives: Type II diabetes is a metabolic disorder accompanied with insulin resistance of the whole body cells and is considered be the fifth cause of death in the world. Adaptation to altitude can lead to tolerance to many diseases. Therefore, the aim of this study was to determine the effect of simulated intermittent altitude on the metabolic and hematologic parameters and liver function in streptozotocin induced diabetic rats.
Methods: In the current experimental study, twenty four male Wistar rats weighing 220±20 gr were randomly divided into three groups; normal control group (NC, n=8), diabetic control group (D, n=8) received fat diet for 2 weeks then were injected with streptozotocin (37 mg/kg) and diabetic+hypoxia group (D+H, n=8) including diabetic rat exposed to chronic intermittent hypoxia (PiO2≈106 mm Hg, simulated altitude≈3400 m, 14% oxygen for 8 weeks). Diabetic, hematologic and lipid parameters as well as ALT and AST activities were measured in peripheral blood.
Results: Our findings showed that intermittent hypoxia significantly decreased serum total cholesterol, LDL ,VLDL and triglyceride in D+H group compared to D group (p<0.05). Serum levels of fasting blood glucose and homeostatic model assessment-insulin resistance )HOMA-IR( index and ALT were decreased in D+H group vs. D group )p<0.05). Also, hemoglubin and hematocrite level increased in D+H group in comparison to D group )p<0.05). No significant difference was detected in red blood cell count in D+H vs. D group.
Conclusion: Based on resultant data, it seems that intermittent exposure to hypoxia (simulated to chronic and intermittent lodgement in altitude) can be used to control of type 2 diabetes by increasing hemoglobin, decreasing insulin resistance and improving liver function as well as lipid parameters.
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