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Showing 5 results for Aerobic Exercise

Farnaz Seifi-Skishahr, Arsalan Damirchi , Manoochehr Farjaminezhad , Parvin Babaei ,
Volume 15, Issue 1 (4-2015)
Abstract

  Background & objectives: The “redox” state represents the oxidation/reduction potential within the cell in a way that more “redox” is the marker of health, while the more oxidized reflects predisposition to diseases. Different types of exercise training may change the thiol/disulfide ratio of redox couples such as glutathione and represent a shift in redox balance. This study was assessed the influence of high-intensity aerobic exercise on glutathione redox state in red blood cells in professional, recreational athletes and nonathletes.

  Methods: Ten voluntary well trained (WT), moderately trained (MT) and untrained men subjectswere randomly selected for this semi-experimental study (mean ages of 21.10±1.72 21.70±1.88 and 20.10±1.44, respectively). Blood samples were collected before, immediately, 10 min and 30 min after acute aerobic exercise with 75%VO2max. The levels of reduced glutathione (GSH), oxidized glutathione (GSSG) and (GSH/GSSG) in red blood cells (RBCs) as well as serum levels of cortisol and creatine kinase (CK) were measured.

  Results: The results showed reduction, elevation and no changes in RBCs GSH/GSSG ratio in UT, MT and WT groups, respectively. The lowest levels of GSH/GSSG ratio in RBCs and the highest one were detected in the WT and MT groups, respectively. The serum levels of cortisol and creatine kinase were increased following the exercise in three groups.

  Conclusion: It is concluded that acute aerobic exercise with high intensity does not change redox balance in well trained subjects, however it is capable to shift redox balance towards more reducing environment in moderately trained subjects and also to more oxidizing one in untrained subjects.


Mr. Ahmad Fazeli Sani, Dr. Hasan Matin Homaee, Dr. Abdolali Banaeifar,
Volume 20, Issue 3 (10-2020)
Abstract

Background & objectives: Mitochondrial dysfunction is one of the main risk factors for neurological diseases which are associated with aging. On the other hand, aerobic exercise has beneficial effects on the brain health and cognitive function, and also improves mitochondrial dynamics. Therefore, the aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on spatial learning, memory performance and mitochondrial dynamics in the hippocampal tissue of old rats.
Methods: For this purpose, 14 male Wistar rats at 20 months of age were randomly divided into 2 groups: aerobic exercise (n=7) and control group (n=7). The exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes were assayed using Real Time-PCR. The Independent t test was used for statistical analysis.
Conclusion: Aerobic exercise in old animals improved spatial learning and memory performance, increased hippocampal OPA1 gene expression, and decreased Drp1 gene expression compared to the control group (p≤0.01).
Conclusion: It seems that aerobic exercise can improve the function of brain mitochondria by modulating fusion and fission processes and it can be considered as an effective non-pharmacological method to deal with aging-related learning and memory perturbations.
Ensieh Ahmadpour, Maghsoud Piri, Mohammad Ali Azarbijani,
Volume 21, Issue 4 (1-2022)
Abstract

Background & objective: Alzheimer's disease (AD) is the most common cause of dementia among the elderly, threatening their quality of life. On the other hand, regular exercise is associated with improved brain health and cognitive function. However, the mechanisms of these benefits have not yet been fully elucidated. Therefore, the aim of this study was to investigate the effect of 4 weeks of moderate intensity interval aerobic training on cognitive function and expression level of PGC1α and VEGF genes in the hippocampus of old rats with AD.
Methods: For this purpose, 20-month-old male Wistar rats were divided into three groups of AD (n=8), AD+exercise training (n=8) and control (n=8). Intra-hippocampal injection of Aβ42 was used to induce AD. The animals in the exercise group performed moderate-intensity interval aerobic exercise for 4 weeks, 5 days a week. To assess spatial learning and memory, the animals underwent the Morris water maze test 48 hours following the last training session. Then, the animals were killed and hippocampal tissue was extracted. Real time-PCR method was used to measure gene expression. Statistical analysis was performed using one-way analysis of variance and Pearson correlation coefficient at the significance level of p£0.05.
Results: The results showed that Aβ42 injection impaired spatial learning and memory function and reduced the expression level of PGC1α and VEGF genes in hippocampal tissue (p£0.05). Aerobic exercise improved spatial learning and memory function and increased PGC1α and VEGF genes expression (p£0.01). Also, a significant positive relationship was observed between the PGC1α and VEGF gene expression levels in the hippocampus (r= 0.859, p≤0.01). In addition, there was a significant inverse relationship between PGC1α and VEGF genes expression and the mean time spent to find the platform (r= -0.9, p£0.01 and r= -0.750, p£0.01, respectively), and a significant positive relationship with the time spent in the target quadrant (r= -0.794, p£0.01 and r= -0.632, p£0.01, respectively).
Conclusion: In general, aerobic training improves spatial learning and memory performance in old animals with AD; up-regulation of the exercise-induced PGC1α/VEGF pathway in the brain, at least in part, appears to be involved in this adaptation.

 
Maryam Zolfali Pourfar , Farhad Rahmani Nia, Parvin Farzanegi,
Volume 21, Issue 4 (1-2022)
Abstract

Background & objectives: Dynamic disorders of mitochondria cause the pathogenesis of many diseases, such as type 2 diabetes. Therefore, the aim of this study was to investigate the interactive effect of aerobic exercises and atorvastatin consumption on the expression of MFN1/2 and DRP1 in hepatocytes of rat liver with type 2 diabetes.
Methods: In this experimental study, 25 male rats were divided into 5 equal groups: diabetes, healthy control, persistence+diabetes, atorvastatin+diabetes, persistence+atorvastatin+ diabetes. Type 2 diabetes was induced by streptozotocin (STZ) in mice. The training groups performed the running program on the treadmill for eight weeks. Atorvastatin and atorvastatin-exercise groups received atorvastatin (10 mg/kg) by gavage. 48 hours after the last training session, the rats were dissected; their liver tissue was removed and immediately frozen in liquid nitrogen solution at a temperature of minus 80 ° C to measure MFN1/2 and DRP1. One-way analysis of variance and Tukey post hoc test were used for statistical analysis at a significance level of p<0.05.
Results: The results showed that induction of type 2 diabetes decreased the expression of MFN1/2 and increased DRP1 compared to the healthy group. After eight weeks of intervention, a significant increase was observed in the expression level of MFN1 (p<0.05), but this increase was not significant in MFN2 and there was no significant difference in the expression of factors between the groups. Also, after eight weeks, a significant decrease in DRP1 gene expression was observed (p<0.05). This decrease was significant in comparison with the combined groups compared to the patient group.
Conclusion: It is possible that a combination of aerobic exercises and atorvastatin may positively regulate the expression of genes related to mitochondrial dynamics in diabetes.
 
Hamid Vasfi, Hamid Mohebbi, Marefat Siahkouhian, Lotfollah Rezagholizadeh, Abuzar Jorbonian,
Volume 24, Issue 1 (4-2024)
Abstract

Background: Weight gain and obesity are the global health problem. Time-restricted feeding is a relatively new method of weight loss with many metabolic and anthropometric benefits. Low-intensity aerobic exercise also has beneficial effects on weight loss and metabolic factors; However, the combined effect of TRF and low-intensity aerobic exercise on metabolic and anthropometric factors in healthy overweight middle-aged men has rarely been investigated. The present research has investigated this purpose.
Methods: Among 55 volunteers, 27 healthy middle-aged men in the age (35 to 55) with overweight (25 The groups included: 1-TRF18:6 & EX 2-TRF 16:8 & EX 2-TRF 14:10 & EX. Three groups performed TRF protocols with different feeding times (6, 8 and 10 hours of free feeding) and fasting in the remaining 24 hours, and the same low -intensity aerobic exercise (55-65% of maximum heart rate). The interventions continued for 12 weeks. Blood and body composition tests were measured before and after the intervention. Daily food intake was measured before the intervention and during 12 weeks. Finally, all the data were analyzed.Analysis of variance with repeated measures was used for analysis. P values ​​less than 0.05 were considered as a significant criterion in all statistical tests.
Results: The combination of TRF and exercise decreased glucose and insulin resistance in all groups. Cholesterol and LDL decreased in the 6-h and 8-h TRF groups. HDL reduction was significant only in the 8-h TRF group. Weight and BMI were reduced in the 6-h and 8-h TRF groups. The percentage of fat reduced in the 6-h group.  There was no significant difference between the groups for any of the variables. The average energy received in 12 weeks was not significantly different in any group; however the 6-h model caused a greater decrease in the average energy received during 12 weeks than in the other two groups.
Conclusion: The 6-h TRF model along with light aerobic exercise is suggested as the most reliable method to improve the metabolic and anthropometric profile in overweight middle-aged men.
 


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مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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