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Showing 9 results for Abortion
Nayereh Aminisani , Seyedmorteza Shamshirgaran , Farnaz Ehdaivand , Afrooz Mardi ,
Volume 3, Issue 1 (4-2003)
Abstract
Background & Objective : Breast cancer is the most common type of cancer among women worldwide and accounts for the majority of their deaths due to the cancer. Hence, diagnosing its risk factors is of great importance. In this study the association between abortion and breast cancer risk was investigated. Methods : In this Case- Control study in Mashhad, 105 patients with confirmed breast cancer were compared with 105 healthy women who were living in their neighborhood and were the same age. A questionnaire including demographic information as well as same questions regarding the factors associated with conception and emphasising abortion were used to collect the data, which then were analyzed using SPSS ver 9. Results : the findings indicated a relationship between breast cancer and history of abortion, compared to women with no history of abortion (OR=2.09 95% CI=1.18- 3.69). Also there was a significant relationship between the frequency of abortion and breast cancer (P=0.008 ). but odds ratio was not higher among women whose age at first abortion was less than 20 years. Also abortion before first full- term pregnancy increased breast cancer risk (OR= 5.97 95% CI=1.18-19.6). But the age at the time of abortion did not have any effect on the breast cancer risk. Conclusions : The findings suggested that the risk of breast cancer has a positive relationship with frequency of abortion and the risk is even higher if the abortion occurs before the first full-term pregnancy. Thus, health interventions seem to be necessary in this regard.
Masoumeh Hajishafiha, Shaker Salari Lac , Minoo Khairi Tabar , Siyamak Naji, Mahzad Sadaghiani , Nahideh Asadi ,
Volume 11, Issue 1 (4-2011)
Abstract
Background & objectives : Today there is a significant progress in the treatment of female infertility but there is no main improvement for the rate of implantation and live birth. This is because of non-implantation and early abortion that lead to decrease the rate of live birth. Genital infections such as bacterial vaginosis are common cause of this problem. Distinction and treatment of bacterial vaginosis is easy and non-expensive. Treatment of bacterial vaginosis could results in improving the rate of implantation and then live birth. Methods: We considered 209 infertile women treated with ICSI (intra cytoplasmic sperm injection). This study was performed in infertility clinic of KOSAR hospital affiliated to Urmia University of Medical Sciences, Iran. Before transferring of embryo, a sample was taken from posterior culdesac secretions by sterile cotton swap and fixed it on lamella. Then bacterial vaginitis was graded by a pathologist. The relationship of bacterial vaginosis with implantation and early abortion was studied. Data were entered into SPSS software and analyzed by t-test and Chi-Square test. p<0.05 is considered statistically significant. Results: Bacterial vaginosis was significantly more frequent in patients with tubal and ovulatory disorder (p=0.013). In women undergoing ICSI, bacterial vaginosis was not associated with decreased conception rate (p=0.892) and with increased rate of early pregnancy loss (p=0.44). Conclution: Bacterial vaginosis is prevalent in women with infertility. It is also the most important cause of infertility in patients with tubal and ovulatory disorder. Bacterial vaginosis does not affect fertilization rate.
Roya Motavalli, Leila Alizadeh, Maryam Namadi Vosoughi, Samira Shahbazzadegan,
Volume 12, Issue 4 (12-2012)
Abstract
Background & Objectives: Induced and unhealthy abortion is common condition in the worldwide, particularly in developing countries as Iran which accompanies with maternal mortality and morbidity. The aim of this study was to obtain the prevalence, risk factors and complications of induced abortion. Methods : A retrospective study was conducted in 1200 women, who referred to health centers of Ardabil. The eligible participants were included by random sampling. We used a prepared questionnaire with questions on demographic characteristics, pregnancy history and contraception methods. To determine the validity and reliability of questionnaire the content validity and re-test methods were used respectively. Statistical analyses were performed with SPSS software (pakage 16) using t-test and chi-square. Results: The prevalence of induced abortion was 8.3%. The main reason was represented having desired number of children. Other reasons were economic hardship situation, low pregnancy interval, undesirable fetus gender, parents age, academic education and occupation of mother and increased duration of being married (p<0.0001). The complication of induced abortion were vaginal bleeding (70/5%), bleeding and infection (7/4%), and hospitalization (49/5%). Conclusion: According to the results of this research it is expected that authorities and health personnel detect the high risk group of society and present necessary education and individual consultations to more awareness and change their attitude and beliefs on acute complication resulted from induced abortion.
Parviz Amri Maleh, Mojdeh Camvar ,
Volume 14, Issue 2 (7-2014)
Abstract
Background & objectives: Eisenmenger syndrome associated with pregnancy increases the maternal morbidity and mortality . Therefore, in the most of such patients the termination of pregnancy is recommended. Case report: A 29 -year-old woman at the 7 th week of gestational age was candidate for therapeutic abortion with history of Eisenmenger syndrome due to atrial septal defect (ASD) . Spinal a nesthesia was performed in sitting position at the L4-5 interspace with 10 mg of bupivacaine . The p atient was laid in the supine position after 2 minutes. The surgery lasted about an hour . Blood pressure and heart rate did not change significantly during operation. Conclusion : Modified s pinal anesthesia with bupivacaine is recommended for therapeutic abortion in patients with Eisenmenger syndrome.
M Bonyadi , A Mohammadi , M Khalajkondori, S Taghavi ,
Volume 15, Issue 2 (7-2015)
Abstract
Background & objectives: Recurrent spontaneous abortion (RSA) is defined by two or more consecutive miscarriages before 20 weeks of gestation. Adenosine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2. The adenosine deaminase G22A polymorphism (ADA*2) increases the level of adenosine. Adenosine may play a protective role against recurrent spontaneous abortions, since it regulates blood flow into the uterus and placenta. In consideration of the effect of decreased enzymatic activity of adenosine deaminase G22A polymorphism on adenosine levels we evaluated the protective effect of ADA*2 allele against recurrent spontaneous abortions in north-west of Iran.
Methods: A total of 100 women were recruited to form two groups. First one, with a history of recurrent spontaneous abortions (N=50), and the second one, without a history of abortions (N=50). Genomic DNA was extracted from peripheral blood with a commercial kit and PCR-RFLP analysis was used to identify the G22A genetic polymorphism. Fisher's exact test and odds ratio values were used to compare the proportions of adenosine deaminase genotypes and alleles between women with and without a history of recurrent spontaneous abortion (p<0.05).
Results: The frequency of homozygotes (AA) was 2% in control group, whereas no homozygote (AA) was found in the case group. The frequency of heterozygotes (AG) was 20% in control group and 8% in the case group (p<0.05). The frequency of homozygotes (GG) was 78% in control group and 92% in the case group (p<0. 05). A significant increase in the frequency of AG genotype in controls (p=0.014, OR=0.348) relative to women with the history of RSA demonstrates the protective effect of AG genotype in controls.
Conclusion: The data suggest that women carrying the G22A polymorphism (ADA*2 allele) and AG genotype which is associated with the lower enzymatic activity are better protected against recurrent spontaneous abortions.
Rana Alizadeh Hajikhajehlu , ,
Volume 17, Issue 1 (4-2017)
Abstract
Background & Objectives: Infertility (abortion & stillbirth) is one of the most common medical problems during pregnancy. Approximately 10-15% of all clinically recognized pregnancies are lost before the birth. Pregnancy loss is a multifactorial phenomenon. This study was an attempt to analysis the cytogenetic abnormalities of the parents with frequent spontaneous abortion and stillbirth.
Methods: In this study, the samples were analyzed by GTG-banding technique.
Results: From a total of 200 reviewed blood samples, 188 persons (94%) had natural karyotype and 12 persons (6%) had chromosomal abnormalities. Chromosomal aberrations were found in 5 (2.5%) females and 7 (3.5%) males. The prevalence of chromosomal abnormalities was as follows: 5(41.6%) pericentric inversion of chromosome 9, 3 (25%) polymorphism 15p+, 1(8.3%) translocation, 1 (8.3%) polymorphism 15ps+, 1 (8.3%) polymorphism 1qh+ and 1 (8.3%) unknown chromophil band on the short arm of chromosome 21.
Conclusion: Chromosomal analysis is an important etiological investigation in couples with recurrent spontaneous abortions and stillbirth, and genetic counseling helps to make a correct decision on further options of reproduction.
Mortaza Nourmohammadi, Hosein Hamidinejat, Mohammadreza Tabandeh, Saad Goraninejad, Somaye Bahrami,
Volume 17, Issue 3 (10-2017)
Abstract
Background & objectives: Toxoplasma gondii is a zoonotic obligate intracellular protozoan parasite that infects all warm-blooded animals as well as human worldwide. Determining the parasite genotype in intermediate hosts is crucial in evaluating the role of these types in human infections as wll as in prevention programs. Therefore, this study aimed to identify and detect the genotypes of Toxoplasma gondii in aborted fetuses of ewes in Lorestan province.
Methods: Identification of the parasite was performed on the brain and liver tissues of 142 aborted fetuses using a conventional PCR based on amplification of highly repetitive 529 bp region of the parasite genome. Genotyping of positive samples, which were isolated from the brain and liver, was performed by PCR-RFLP based on SAG2, SAG3 and GRA6 molecular markers.
Results: From a total of 142 samples obtained from brain and fetus, 10 cases (7%) were determined as positive samples based on conventional PCR. The precence of parasite DNA was also confirmed in the liver of 3 positive samples. Evaluation of RFLP pattern of amplified SAG2, SAG3 and GRA6 genes showed the presence of various types of parasites, incuding type I in 3 samples, type II in 2 samples and atypical type in 5 samples.
Conclusion: Isolation of types I, II and atypical type of T. gondii from ewes in Lorestan province suggests the need for greater attention to parasite transmission from livestock to human, particularly in pregnant women and people with weakened immune system.
Faiba Kahnamooi, Firooz Amani, Mahsa Vallaei , Mahnaz Azari,
Volume 17, Issue 4 (1-2017)
Abstract
Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by a number of medical or mechanical methods. The aim of this study was to compare the efficacy of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria in preoperative cervical ripening among women with under second-trimester abortion.
Methods: In this interventional study, 120 pregnant women with the gestational age of 20 weeks, who were candidates for therapeutic abortion, were selected and randomly divided into three groups (n=40). Proper counseling was done and a written informed consent was obtained before starting the treatment regimen. The first group received vaginal misoprostol alone and the second group received misoprostol in combination with laminaria and oral placebo. In the third group, in addition to cervical placebo on the first and second days, letrozole was prescribed, and on the third day, the patients were hospitalized and received vaginal misoprostol and third dose of letrozole. The patients were regularly examined every 4 hours, and in the absence of abortion, vaginal misoprostol was repeated after 4 hours.
Results: The results showed that termination of pregnancy was caused by embryo anomaly in 23 cases and fetal death in 97 cases. In this study, response to treatment was 90% in the group receiving laminaria and misoprostol 85% in the group receiving letrozole and misoprostol and 67% in the group receiving misoprostol. Regarding the duration and amount of bleeding, the groups receiving laminaria and misoprostol had the lowest duration and severity of bleeding, but this difference was not statistically significant. Combination of misoprostol and laminaria caused a significantly shorter time interval from the initiation of intervention to abortion, and pain relief was also higher than the other two groups.
Conclusion: Based on the obtained results, a combination of misoprostol and laminaria is recommended for induction of second-trimester therapeutic abortion.
Morad Beiranvand, Hossein Hamidinejat, Somayeh Bahrami, Mohammad Reza Tabandeh, Meysam Makki,
Volume 24, Issue 2 (7-2024)
Abstract
Background: A zoonotic obligate intracellular protozoan parasite, Toxoplasma gondii, infects all warm-blooded animals as well as humans worldwide. Identification of the level of infection in intermediate hosts gives us an important data about understanding the role of this parasite in human health as well as estimating the economic loss in livestock. Therefore, the main aim of this study was the isolation and identification of T. gondii from aborted goat fetuses by PCR in Lorestan province.
Methods: From autumn 2023 to summer 2024, the brain and liver of 100 goat fetuses were examined for T. gondii by PCR based on the amplification of 529 base pair fragments from repetitive regions of the parasite genome. The study was performed in three aborted fetus groups, less than 2 months, 2 to 4 months and more than 4 months.
Results: From a total of 100 examined samples, conventional PCR detected the T. gondii infection in 6 (6%) and 2 of the brain and liver fetuses respectively.
Conclusion: This study shows a notable level of infection in goat fetuses, and as a result, T. gondii should be considered an important agent involved in the abortion of goats in the Lorestan province of Iran. On the other side, it is necessary to pay more attention to the risk of transmission of this parasite from farmed animals to humans, especially pregnant women and people with suppressed immune system.
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