|
|
|
 |
Search published articles |
 |
|
Showing 42 results for Subject: Exercise physiology
Rezvan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Given the secretion of myokines from muscle tissue during exercise and their relationship with muscle strength development, the present study aimed to investigate the relationship between muscle strength and serum levels of irisin, brain-derived neurotrophic factor, myostatin and follistatin in inactive men and women following 12 weeks of strength training.
Methods: In this quasi-experimental study, 10 women (age: 37.6±6.09 years, weight: 80.5±20.76 kg) and 20 men (age: 39.6±6.05 years, weight: 84.89±5.67 kg) voluntarily participated. The subjects performed 12 weeks of strength training, 3 sessions per week, with an intensity of 65 to 80% of maximum strength. Blood samples were taken for measurement of irisin, brain-derived neurotrophic factor, myostatin, and follistatin by ELISA.
Results: Strength training significantly increased serum irisin, serum BDNF, follistatin and significantly decreased myostatin and fat percentage in both male and female groups (p≤0.05). There was also a positive and significant relationship between lower body strength and irisin in women (p=0.040) and upper body strength in women and BDNF (p=0.038). The results in the male group showed a significant and positive relationship between serum irisin levels with upper and lower body strength and follistatin with lower body strength (p≤0.05).
Conclusion: According to the results of the study, strength training in inactive individuals reduces serum levels of myostatin , increases secretion and serum levels of irisin, BDNF, follistatin, and increases muscle strength.
Zahra Kargar Dolatabadi, Abdossaleh Zar, Sara Zare Karizak, Rouhollah Ranjbar,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Various signaling pathways are involved in causing hypertrophy in different organs of the body. One of these important pathways is the mTOR signaling pathway, which, as a key regulator in cellular growth and metabolism processes, plays an important role in muscle hypertrophy and kidney function. The aim of the present study was to investigate the effect of resistance training and Spirulina supplementation on the expression of IGF-1, AKT, Rheb, and TSC2 genes in male rats.
Methods: 32 male Sprague Dawley rats, 3 months old and weighing 150 ± 20 g, were randomly assigned to four groups: resistance training + spirulina supplement, resistance training, spirulina supplement, and control. Spirulina was orally administered to rats in the spirulina and resistance training plus spirulina groups at a dose of 200 mg/kg body weight per day for eight weeks. The resistance training protocol consisted of eight weeks of ladder climbing to a height of one meter. The expression levels of IGF-1, AKT, Rheb, and TSC2 were measured using Real-time PCR.
Results: The expression levels of IGF-1 (p<0.001), AKT (p<0.0001) and Rheb (p<0.0001) genes showed a significant increase in the exercise + supplement group. While the expression of TSC2 gene was significantly decreased in the exercise + supplement group (p<0.0001).
Conclusion: The findings indicate a positive effect of resistance training and Spirulina supplementation on the expression of IGF-1, AKT, Rheb, and TSC2 genes in kidney tissue.
|
|
.png)
.png)
