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Showing 885 results for Type of Study: article
Hosein Noug , Ali Khodadadi, Hamid Bakhshi ,
Volume 4, Issue 1 (4-2004)
Abstract
Background &Objective: Infarctian size is the most important prognostic factor in patients with acute myocardial infarction (AMI). Reperfusion therapy using thromboliatics is the most important measure in order to limit the infarction, size. Infarction size on the other hand, associates directly with left ventricular (LV) function. The presence of Q wave on electrocardiogram (ECG) after thrombolytic therapy is associated with increased mortality during first months after AMI. Moreover electrocardiographic changes after thrombolytic therapy can predict LV function. This study is an attempt to evaluate the relationship between electrocardiographic Q wave and LV function after thrmobolytic therapy in patients with MI. Methods: 176 patients with first episode of AMI (diagnosed based on WHO criteria) who were receiving streptokinase took part in this analytical study. ECG of the first day after admission and ECG of discharge day (usually the sixth day) were evaluated in terms of the presence of pathologic Q wave. LV function was evaluated by Echocardiography using Simpson method. The data were analyzed by SPSS program using chi-square test. Results: On discharge day 82.4% of the patients had pathologic Q wave and 17.6% were without it. 51.6% of patients without pathologic Q wave, had normal LV function (LVGF>55%) while 26.9% of them had Q wave (p= 0.001). 73.3% of males and 56.4% of females had Q wave on ECG. Conclusions: Presence of Q wave on ECG in patients with AMI after thrombolytic therapy correlates with LV function and indicates impaired LV function in these patients.
Maziyar Hashemilar , Nayereh Aminisani , Darioush Savadi Oskoui , Mahzad Yosefian ,
Volume 4, Issue 1 (4-2004)
Abstract
Background & Objective: Studying the epidemiology and impact of headache can help improve patient care, estimation of burden of disease and classification systems. Migraine is common worldwide and has a geographically variable prevalence in the world. Moreover, its peak of incidence is the age of 20-30. The aim of this study was to determine the prevalence of migraine among the medical students in order to plan for future health interferences. Methods: In this cross-sectional study 631 students filled out a questionnaire designed according to the criteria of the international headache society. The data were analyzed using SPSS software (release 12) and descriptive statistics. Results: 76.6% of the subjects were female and 23.4% of them were male. The females were 20.6 and males were 21.4 years old on average. The total prevalence of migraine was 7.3% (1.6% with aura, 5.4% without aura and 0.3% with both of them). Moreover, females, single subjects and students of medicine, except the migraine with aura that was more prevalent among students of associate degrees. A positive family history of headache was found in 45.6% of the students. 65.2% of those suffering from migraine had not referred to a physician and were unaware of their headache. Conclusions: Compared to similar researches there is a low prevalence of migraine among the students but most of the students do not take measures to cape with and treat them in the proper manner. This requires necessary health interferences.
Nayereh Aminisani , Seyedhashem Sezavar , Rasool Lotfollahzadeh , Nazila Vosogh,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Research has always been considered as a powerful tool in creating change and development and like any other process it demands careful planning, providing facilities and special resources. Investigating research trends can pave the way for systematic thinking in this regard. This study was conducted to examine trends in research methodology in order to promote the research quality in Ardabil University of Medical Sciences. Methods: In this cross-sectional descriptive study, data regarding research methodology and its administration was evaluated by a questionnaire during six years from 1997 to 2003. The data regarding the author of the research were collected through the interview. These data were then analyzed by SPSS software (release 12) using descriptive statistics. Results: Between 1997 and 2003, 196 research proposals were approved. The number of research designs increased from 3 to 45 during this period. Most of these studies (58.2%) had cross-sectional design. The experimental researches came second with 43 cases (21.9%). During this period the number of trials and analytic studies increased, but descriptive studies were still in the highest rank. Only 32% of the proposals were completed properly and in most of the cases they were not completed in the proper way and some subsections of the forms such as design, variable table, methods of data analysis, data collection procedures and administration problems were incomplete or missing in most of the designs. These problems were more evident before the establishment of research consultation office in 2001. 75% of the researchers had attended research workshop before conducting any research. Conclusion: The findings indicated a remarkable increase in the number of researches compared to the preceding years. Moreover, they have been more analytically-oriented. However, descriptive researches are in the top rank. Some necessary measures have to be taken in order to improve the present condition.
Farnaz Ehdaivand , Masoumeh Rostamnegad , Homayoun Sadeghi , Nayereh Aminisani,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Cesarean section is one of the most common surgeries in women. In developed countries the rate of cesarean section is reported to be 21.2%. In Iran, the rate of cesarean section is even higher than the international norms. In a study in Ardabil, in 2001, cesarean section rate came out to be 42.86%. Postoperative pain after cesarean is one of the complications that all mothers experience in one-way or another. Besides bothering mother it can disorder newborn feeding, ambulation of mother and bonding between newborn and mother if it is not controlled effectively. This study was conducted to compare the effect of intramuscular Methadone and Diclofenac suppository for pain relief after cesarean section in Alavi hospital, Ardabil. Methods: This study was a double blind clinical trial. 56 women who experienced cesarean section for the first time were randomly divided into two groups. Diclofenac suppository (100 mg every 8hr) was given to first group and Methadone (5 mg every 8hr) was injected to the second group for 24 hours. Then, the severity of pain was measured with numerical scoring in serial postoperative visits. The data were analyzed by SPSS software using descriptive and analytical statistics such as chi-square and ANOVA. Results: The findings indicated that the severity of pain in 2nd, 3rd and 4th postoperative visits was significantly lower in patients who received Diclofenac suppositories than the other group (p<0.05). But overall, there was no statistically significant difference between the pain severity in Methadone receiving group (Mean & SD= 5.85 ± 3.5) and Diclofenac receiving group (Mean & SD= 6.46 ± 2.9). Conclusion: There was no significant difference between Diclofenac suppository and Methadone in terms of decreasing the postoperative pain after cesarean section. However, regarding the restrictions in the use of opioids, Diclofenac can be a suitable replacement for these drugs.
Manoochehr Barak , Nayereh Aminisani , Nategh Abbasgholizadeh , Mehrdad Mirzarahimi ,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objective: Each year thousands of children under five years old die due to acute respiratory infection and diarrheal diseases. A huge number of infants and children are hospitalized and visited by the physicians whereas most of these diseases can be prevented with timely treatment. Child health maintenance and improvement is one of the most important considerations in each society. Moreover, identifying child morbidity patterns should be a matter of concern in order to improve the health services. This study provides an overview of the leading causes of hospitalization among children with the aim of determining the most important causes of hospitalization and offering appropriate strategies to decrease them. Methods: This cross-sectional study was conducted in 2001 in Ardabil Ali-Asghar hospital. The subjects were randomly selected from the admission list on a daily basis. A questionnaire including demographic characteristics such as age, sex, time of admission and primary diagnosis was completed for each subject. The data were analyzed by SPSS software using descriptive statistics. Results: A total of 1945 patients were admitted almost half of which were studied. Febrile convulsion was found to be the most common cause of hospitalization (26%) while gastroenteritis (22.1%) and pneumonia (20%) were in the second and third order. Other causes included epilepsy, drug poisoning, meningitis, mumps, drug encephalitis, asthma, etc. Conclusion: According to the findings of this study, standard case management is necessary especially about febrile convulsion which is the most common cause of hospitalization. Since the present pattern is different from similar studies, further investigations are required to identify its causes.
Soheila Rabiey Poor , Shohreh Afshar Yavari ,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives : Smoking is one of the major problems in the world today. It threatens people ’ s health. Pregnant women are no exception in this regard. Today, it is found that smoker women bear low birth weight babies, but the studies don ’ t offer clear findings about passive smoking in pregnancy and its effect on weight and height of newborns. This study is an attempt to determine the effects of passive smoking on the weight and height of the newborn babies. M ethods : This was a retrospective cohort study. We studied 100 pregnant mothers who were exposed to cigarette smoke and 100 others who were not. A checklist was completed in order to select those who could enter the study. A questionnaire was then filled out for both groups including the information related to the newborns ’ physical specifications. Results: This study showed that the average age of the mothers, their education, their husband ’ s education, number of pregnancies and the sex of babies born weren ’ t meaningfully different between the two groups. In the case group the mothers were exposed to cigarette smoke for 2.36 ± 2.28 hours on average and most of them (72%) were exposed to their husbands ’ cigarette smoke. The findings also indicated that difference in weight, height and head circumference among two groups ’ newborns were 11 grams, 0.15 cm and 0.02 cm respectively. The T-test indicated no significant difference between the two groups. Conclusion: The study showed that the newborns ’ of mothers exposed to the smoke had lower weigh, height and head circumference than the babies ’ of the control group subjects although the difference was not statistically significant.
Masoumeh Rostamnegad, Firooz Amani ,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Mother ’ s milk is the best food for the newborns and has positive effects on both mother and infant health, decreasing infant mortality, satisfying emotional needs of mother and infant and economizing the domestic as well as social expenditures. Unfortunately, because of different economical, social and cultural reasons in many parts of the world breast feeding and its length of time has decreased. WHO emphasizes breast feeding in the first six months of life in developing countries. This study is an attempt to determine the causes of unsuccessful breast feeding in the first six months after birth in Ardabil. Methods : This descriptive analyticalstudy was conducted on 160 mothers who had 2- month- old or younger infants and did not have exclusive breast feeding until the end of 6 months. The researchers referred to 4 health centers, selected based on cluster sampling, in order to select the qualified mothers and complete the questionnaires in their presence. Results: Most of the mothers (37.5%) have begun feedings supplementary nutrition to their infants at the age of 2-4 months. The most common (90.5%) cause for the lack of the exclusive breast feeding was found to be insufficiency of mother milk.Most of the mothers (67%) stated the infant cry as the main reason for this insufficiency. There is a significant relationship between exclusive breast feeding on the one hand and the delivery, time of first feeding, occupation and mother ’ s education on the other (p<0.05). Conclusion : Social and economic conditions and misbeliefs have all affected the success of exclusive breast feeding. Most of these problems can be prevented through proper trainings.
Saeid Sadeghieh Ahari , Ahad Azami , Manoocher Barak, Firooz Amani , Seddigh ,
Volume 4, Issue 2 (6-2004)
Abstract
Background and objectives: Establishing centers to stop addiction in our country is one of the measures taken to confront this problem. Unfortunately, it has been shown that about 80% of the addicted people who refer to these centers relapse. The present study set out to investigate the possible causes of this problem. Methods: This is a case control study in which a questionnaire was used to collect the required data. The subjects were all addicted people who referred to Shahid Mellat Doust and Shahid Family treatment centers in 2000. The criterions for entering the study in case group were the last record of the addicted person ’ s abandonment in Tehran ’ s welfare center ( based on the patients ’ records) and using narcotics at the present time. The control group subjects, on the other hand, had abandoned using narcotics at least four months before and had never used any substance so far. Results: The mean age for case group was 35.99 and that of the control group was 35.09. Regarding the age distribution 98.59% of the case group and 100% of the control group were men. 88.7% of the case group and 97.2% of the control group were urban residents. Considering the job, 40.8% of the case group and 19.4% of the control group were unemployed. 52.1% of the case group and 61.6% of control group were living with their spouses. Opium was the most commoly used narcotics in both groups. In studying the relationship between the variables under study through logistic regression the job was not a main factor in the relapse. The duration of time being away from addiction had a deductive effect on the relapse, and this effect was statistically meaningful (p=0.001). Adding one month ’ s time to the period of being clear (not using the narcotics) caused 98% deduction in returning to narcotics. Conclusion: Because 80% of the patients who referred to the related centers began using narcotics again during the first 6 months after abandoning, it is necessary to improve the preventive measures to help the patients pass this critical period.
Rahim Masoomi,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Senile cataract is one of the most common diseases in the world and a common cause for reduced visual acuteness and blindness. It is due to many factors the most important of which is aging. Other risk factors include gender, smoking, sunlight, living environment, high risk professions, family history, systemic diseases, etc. The present study was an attempt to investigate this disease epidemiologically and draw a general profile for it in order to pave the way for further research. Methods: This was a cross-sectional descriptive and retrospective study. The files of the patients who had received senile cataract surgical operation in Alavi hospital from March 1999 to February 2000 were investigated to collect the required data. The data were analyzed using appropriate statistical methods. Results: 218 patients were studied. The prevalence of this disease was found to be 83.9% which was observed among males more than females and was more common in the 6th decade of life. The disease was mostly seen in the left eye and reduced visual activity to the light perception was the most common clinical complaint among the patients. 29% of the patients were diabetic and 22.1% of them had hypertension. Conclusion: Because of high prevalance of cataract, it is necessary to have good medical care and management. Moreover, some training and guidelines seem necesarry.
Farnaz Moslemi Tabrizi, Soosan Rassooli , Simin Atash Khoii , Rasool Azarfarin ,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Nitroglycerin is found to have vasodilatory effect. It has also a relaxing effect on the smooth muscles of other organs including uterus. This study investigates the effect of intravenous nitroglycerin in emergency cesarean sections in which rapid and transient uterine relaxation for rapid and nontraumatic extraction of the fetus is necessary. Methods: Sixty pregnant women who were candidated for emergency cesarean and needed rapid uterine relaxation for different reasons were selected. These subjects underwent spinal anesthesia and at the time of uterine incision, 100 micrograms of nitroglycerin was injected to them intravenously. The time lapse between nitroglycerin administration and fetal extraction, the degree of uterine relaxation, the amount of intraoperative hemorrhage, uterine tone after fetal delivery and APGAR scores of the infants were all controlled and recorded. Also with regard to the vasodilatory effect of nitroglycerin and probably its resultant homodynamic problems, blood pressure, heart rate and arterial O2 saturation were recorded before and after nitroglycerin injection and throughout the surgery. Results: The results showed that in 53 (88.3%) of the patients the uterus was acceptably relaxed and the fetus was delivered very easily. Only in 7 patients (11.7%) uterine relaxation was not acceptable. The mean decrease in systolic and diastolic blood pressures after nitroglycerin administration compared with before injection BP was 12.97 mmHg (12.210 %) and 7.86 mmHg (12.208 %), respectively. There was not seen any prolonged effect of the drug such as uterus relaxation tone or abnormal bleeding. Also, none of the delivered infants had low APGAR scores. Besides, in patients with acceptable uterine relaxation the first and fifth minute APGAR score of infants were higher (p = 0.008, p = 0.000). Conclusion: This study shows that nitroglycerin can relax uterine smooth muscles very rapidly and transiently and in emergencies it can be an appropriate alternative to the other tocolytic agents with prolonged effect or onset time.
Mohammad Narimani , Parvin Nakhostine Ruhi , Mahnaz Yosefi ,
Volume 4, Issue 2 (6-2004)
Abstract
Background & Objectives: Postpartum depression, as a mental disorder, is seen in some women and can threaten their mental health as well as their infants. At least 7% of mothers suffer from this problem after parturition. Studies indicate that many variables are associated with this disorder during and after the gestation period. The aim of this study was to achieve the rate of postpartum depression and its relevant variables among women who referred to the parturition ward of Buali and Emam Hossein hospitals in Tehran. Methods: In this cross-sectional descriptive study a questionnaire construced by researchers as well as Beck 21- item depression inventory were used to collect the data. The subjects (100 cases) responded to the questions individually in the hospitals. According to the type of variables, X2 nonparametric test was used in the data analysis. Results: The results of this study indicated that 17% of the subjects were suffering from moderate and severe depression and among the 14 predictive variables of the postpartum depression four variables, namely, matrimonial dissatisfaction, unwanted gestation, unemployment and low economical status of family have significant relationship with the postpartum depression. Conclusion: In comparison with the previous studies, the prevalence of postpartum depression is in higher level therefore, it is necessary to increase the information of parturition ward staff about this disorder and inform them to refer any cases of depression to the counseling centers.
Ghodrat Akhavan Akbary , Abdolrasool Heidari , Shokouh Sadr Azodi ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives : Laryngoscopy and tracheal intubation may lead to tachycardia, hypertension and dysrhythmia or myocardial ischemia. In this double blind study, the effects of midazolam and lidocaine on hemodynamic response to endotracheal intubation have been examined. Methods : 52 ASA class one patients, aged 20-50, who were candidate for elective inguinal hernia surgery with general anesthesia, were randomly assigned to two groups. All patients received normal saline or Ringer's lactate solution (5ml/kg) about 5-10 minutes before induction of anesthesia and were preoxygenated for 3 minutes. Group 1 received midazolam (0.05 mg/kg) and group 2 received lidocaine (1.5 mg/kg) during 3 minutes prior to intubation. Anesthesia was induced with fentanyl (100 µ g) and thiopental (5 mg/kg) and trachea was intubated by the aid of succinyl choline (1.5 mg/kg). Anesthesia was maintained with halothane (0.5-0.75%) and equal proportions of nitrous oxide and oxygen. Systolic and diastolic blood pressure, mean arterial pressure (MAP) and heart rate were recorded before premedication and intubation, as well as immediately two and five minutes after intubation. The data were analyzed by SPSS software using paired t-test. Results : After intubationSystolic and diastolic blood pressure, MAP and heart rate increased in both groups compared to the baseline values. The difference in increasing diastolic blood pressure and MAP between the two groups was significant (p<0.05), but the difference in increasing systolic blood pressure and heart rate between two groups was not statistically significant. The increase in diastolic blood pressure and MAP in group 1 was significantly more than group 2 (p<0.05). Conclusion : Clinically, midazolam was as much effective as lidocaine in controlling response to intubations. Consequently it can be used as an alternative lidocaine in intubations. It has also other priorities such as amnesia, anti-anxiety and anti-agitation.
Farzad Izadi , Seyedbehzad Pousti , Fathollah Mousavi , Mohammad Mohseni , Abtin Doroudinia ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Recurrent respiratory papillomatosis (RRP) is the most common benign laryngeal tumor and the second common cause for hoarseness in children. Despite its omplete benign histology, it has a great tendency to spread through the respiratory track and frequent recurrences may occur following surgery, possibly due to the virus survival in apparently healthy adjacent tissues. According to the most recent evident experiences, the treatment of choice for RRP disease is repetitive resections with CO2 laser. The present study evaluates the efficacy of adjuvant medical therapies for eradication of this disease in affected children. Methods : This was an experimental study with sequential control (self-control). The subjects were children who referred to ENT-H&N surgery dept. of Hazrat-e- Rasoul hospital in Tehran between Mar 1998 and Mar 2001 with chief complaint of hoarseness and respiratory obstruction. Among these children patients with confirmed diagnosis of RRP were selected as study samples and the effect of acyclovir and alpha-interferon combination in reducing the severity and recurrence of RRP was evaluated. Results: Totally 18 patients entered this study (10 (55.5%) females and 8 (44.5%) males). The mean age of the patients was 6.5 and 94% of them were the first child of young mothers (under 25 years of age). The signs of respiratory obstruction in most of the cases with a mild to moderate severity was the main cause of referral in 45% of the subjects. Laryngeal lesions were mostly superficial and limited to glottis region. Severity and spread of RRP disease was greater in children under 3, which led to tracheotomy in 3 of them. The combined administration of alpha-interferon and acyclovir, made a significant reduction in disease severity and spread in 55.6% of the patients. Conclusion : The findings of this study indicated that combination of acyclovir and alpha-interferon can be effective in reducing RRP recurrences and severity. Nevertheless, because of small sample size(due to rarity of RRP), Further multi-institutional studies are required to obtain a greater sample size and more valid results.
Ahmad Daryani , Mohsen Sagha ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Infection with Toxoplasma gondii can cause severe illness when transmitting to fetus or when it is reactivated in immune-suppressed persons. The aim of this study was to determine the prevalence of antibodies against toxoplasma gondii in women referring to laboratory of health center for medical examinations before marriage. Methods: This descriptive cross-sectional study was performed on 504 samples collected from women in Arabil, Iran, in 2002. The samples were studied by indirect immunofluorescent assay (IFA) for determination of IgG and IgM antibodies to toxoplasma. Results: The seroprevalence of IgG antibody at a titer of ³ 1:20 was 34.7%. The highest antibody titer frequency was observed in 1:20 titer (11.7%) and the lowest belonged to 1:3200 (0.4%) and 1:6400 (0.4%) titers. 20 persons (4%) showed IgM antibody against Toxoplama gondii. No statistically significant differences were observed between the prevalence of antibodies on the one hand and age and history of contact with cat or domestic animals on the other. Conclusion: since 65.3% of these women in Ardabil were seronegative, health education is required to omit the risk factors, especially during the pregnancy.
Mohammadhosein Dehghan , Bahareh Rajaee Far , Farnaz Ehdaivand , Firooz Amani ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Preeclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. Despite active researches over the past many years, the etiology of this disorder in human pregnancy is an enigma. Oxidative stress has been implicated in the pathophysiology of preeclampsia. Essential nutrients such as vitamin C can scavenge free radicals inducing cellular damage. The present study was designed to investigate the plasma levels of vitamin C in patients with preeclampsia (case) and normotensive pregnant women (control). Methods: In this case-control study vitamin C as an antioxidant was estimated and compared spectrophotometrically in 40 preeclamptic and 80 normotensive pregnant women referring to Alavi Hospital of Ardabil province, Iran. The collected data were analyzed using descriptive and inferential statistics. Results: The plasma levels of vitamin C were significantly lower in patients with preeclampsia (0.147 ± 0.030 mg/dl) compared to controls who were normotensive pregnants (0.347 ± 0.119 mg/dl). Conclusion: Attempts at prevent preeclamsia are justified but since no reliable screening test has been offered as yet for women at risk, assessment of plasma level of vitamin C in patients prone to preeclampsia is strongly suggested.
Gity Rahimi,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Gestational Diabetes Mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during the pregnancy. Diagnosis of this disorder can prevent complications in mother and her fetus during pregnancy. This study was an attempt to determine GDM prevalence in pregnant women referring to Ardabil health centers. Methods: In this cross-sectional study 601 pregnant women with 24-28 weeks of gestational age were screened by glucose challenge test (GCT) using 50 gr of oral glucose. GCT was considered positive if the serum level of glucose was larger than or equal to 140 mg/dl. Oral Glucose Tolerance Test (OGTT) was done on GCT+ subjects with 100 gr oral glucose. The diagnostic criteria were these of National Diabetes Data Group. Also a questionnaire was used to record history, age, height, blood pressure, weight before pregnancy and other characteristics. The data were analyzed using SPSS software. Results: From 601 pregnant women, 64 cases (10.6%) were GCT+. OGTT indicated that from these 64 cases, 8 cases had GDM (GCT +, OGTT+). GDM prevalence was estimated 1.3%. There was a statistically significant relationship between BMI, mean age and mean diastolic blood pressure on the one hand and GCT and GDM positivity on the other (p<0.05). There was a significant relationship between increasing of BMI and the prevalence of GDM positivity GCT (p<0.05), but the relation was not significant between increasing of systolic blood pressure and gravidity with prevalence of GDM and positive GCT. Conclusion: It seems that the prevalence of GDM in Ardabil is low and general screening is not necessary for all pregnant women. The prevalence of GDM showed an increase with the age of pregnant women, BMI and obesity.
Ebrahim Rahbani Nobar , Mohammad Rahbani Nobar ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives: Lipoprotein [LP(a)] is formed by assembly of LDL particles and carbohydrate rich protein, apolipoprotein(a). LP(a) is elevated in patients with proteinuria or nephrotic syndrome, but it is still controversial whether this is due to hypoalbuminemia or proteinuria. Methods: We studied a group of 71 children suffering from nephrotic syndrome in the absence of renal failure. The levels of serum albumin, LP (a), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C) ,high density, lipoprotein- cholesterol (HDL- C), APOAI and APOB were measured by standard methods. The results were compared with those obtained from 75 age and sex matched normal children as control group. The concentrations of creatinin and protein in random urine samples obtained from children and the protein/creatinin ratio were calculated. The Relationship between measured parameters and/or serum albumin and proteinuria was evaluated. Results: Compared to the control group the serum levels of total cholesterol, triglycerides, LDL-C, LP (a), APOB and APOAI increated (p<0.05 in all cases), but no marked differences were observed in levels of HDL-C in case group. The levels of serum albumin in patient group were significantly lower than that of control (p<0.05). Serum levels of lipids and lipoproteins including APOAI and APOB were more correlated with plasma albumin level than with protein/creatinin ratio in the patient group. Conclusion: The results indicated that in children nephrotic syndrome with on renal failure, the increase of serum levels of LP (a) is mainly related to hypoalbuminemia that stimulates liver synthesis of APOB and is not related to the degree of proteinuria. It was concluded that determination of APOB is the best marker of hyperlipidemia in nephrotic syndrome and normal serum albumin levels seem to be a factor that may determine the of treatment efficacy of hyperlipidemia in nephrotic syndrome.
Seyedhashem Sezavar , Nayere Aminisani , Seyedalireza Alavizadeh ,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objective: Cardiovascular disease is a major global health problem. Countries with low to moderate income contribute significantly to the global burden of cardiovascular disease accounting for 78% of all deaths and 86.3% of all disabilities. This study was an attempt to determine the factors contributing to premature myocardial infarction among young adults in Ardabil city. Methods: In this Case-control study 52 subjects, under 45, with myocardial infarction, admitted to Buali hospital in 2003-2004, were compared with 52 age and sex matched population based controls. Odds ratio and confidence interval of 95% were used to evaluate the risk factors such as smoking, physical activity, family history, history of diabetes and similar factors. Analysis of variance was used to compare the means. Results: The mean age of the subjects was 37.2 and 96.2% of them were male. The positive family history of cardiovascular disease with odds ratio of 9.4 (95% CI=2.6-34.3) and current smoking with odds ratio of 2.8 (95% CI=1.3-6.2) associated with myocardial infarction. Mean of the body mass index and mean of concentration of FBS, LDL and HDL were different in case and control groups. Physical activity with odds ratio of 0.4 had protective effect. (95% CI= 0.2-0.8). There was no meaningful relationship between passive smoking, total cholesterol, education and job with myocardial infarction risk. Conclusion: Family history, smoking, high Fasting Blood Sugar, high LDL, Low HDL and physical inactivity are the most important factors associated with acute myocardial infarction. Proper health interventions should be considered in order to lower the risk factors among young adults especially those under 45 years of age with a positive family history of myocardial infarction.
Mohammadreza Karimazar , Hooshang Khazan , Eznollah Azar Gashb,
Volume 4, Issue 3 (9-2004)
Abstract
Background & Objectives : More than one hundred countries face the problem of malaria disease. Studies have indicated that thalassemic individuals are relatively more resistant to malaria. The present research set out to investigate this hypothesis in Iraushahr where these is a high prevalence of moralia. The goal of this study is to compare the prevalence of malaria in thalassemic individuals with non- thalassemic ones in Iranshahr. Methods: In this case-control study 100 thalassemic individuals (case) and 100 non-thalassemic case (control) were selected. In addition to serum specimen, their blood sample from their fingertips were also taken to prepare peripheral blood smear. The tests were performed on 200 random samples in July (the peak time of malaria transmission). In this study, both indirect immuno flurecance Assay (IFA) and direct amear technique were used. The data were analyzed in SPSS software using descriptive and analytical statistics including T- test, chi-square and ANOVA. Results: In IFA 20 subjects had positive titer while 80 ones had negative titer. Direct microscopic examination indicated that these, 20 cases had malaria parasite, 10 of whom were affected by p. vivax and 10 whit p. falciparum. In the non-thalassemic people (control group), 75 subjects had positive titers and 25 had negative titer. With respect to the direct smear anamination in non-thalassemic subjects, 18 had malaria parasite, of whom 7 had p.falsiparium and 11 had vivax. The results of malaria antibody titer indicated that the history of being affected by malaria the thalassemic subjects was 92% less than the non-thalassemic ones and this difference was statistically, significant (p<0.05) however, no significant relationship was found in terms of the results of direct microscopic examination and Ginsastaining. Conclusion : Since thalassemic people are more resistant againt malaria futhure researches are required to investigated the resistance to malaria in other blood disorders.
Abbas Yazdanbod , Manoochehr Iranparvar, Solmaz Seifi ,
Volume 4, Issue 3 (9-2004)
Abstract
Background &Objectives: According to a recent report published by the Ministry of Health in Iran gastric cancer is the most common cause of death due to cancer in this country and cardiac cancer is the most common kind of upper GI cancer. This study is an attempt to determine the epidemiology of cardiac cancers in Ardabil. Methods: This descriptive cross-sectional study was conducted for four years (2000-2003) at the only private clinic in Ardabil. The results of endoscopy of these patients including the exact determination of the topography of cancer in cardia and other general information were recorded. The data were analyzed using SPSS software (version-10) Results: During this study 4356 endoscopy were done and 533 histologically proven upper GI cancer were detected. Out of 533, 242 cases were located at E-G junction area, 82(33.9%), 130 (53.7%) in cardia region and 30(12/4%) cases were located at the proximal bady of stomach. 130(53.7%) cases of tumors were, in the right side of cardia. Bormann classification showed that most of cancers (43.8%) were ulceroinfiltrative. Conclusion: Statistical analysis indicated that there is a significant relationship between type and topography of cancer with dysphasia, weight loss and epigasteric pain(p<0.05). The results showed significiant relationship between type and topography of cacers with Bormann classification(p=0.001). Further epidemiologic studies are required to evaluate etiology of cardia cancers in Ardabil.
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