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Showing 901 results for Type of Study: article
Morad Beiranvand, Hossein Hamidinejat, Somayeh Bahrami, Mohammad Reza Tabandeh, Meysam Makki,
Volume 24, Issue 2 (7-2024)
Abstract
Background: A zoonotic obligate intracellular protozoan parasite, Toxoplasma gondii, infects all warm-blooded animals as well as humans worldwide. Identification of the level of infection in intermediate hosts gives us an important data about understanding the role of this parasite in human health as well as estimating the economic loss in livestock. Therefore, the main aim of this study was the isolation and identification of T. gondii from aborted goat fetuses by PCR in Lorestan province.
Methods: From autumn 2023 to summer 2024, the brain and liver of 100 goat fetuses were examined for T. gondii by PCR based on the amplification of 529 base pair fragments from repetitive regions of the parasite genome. The study was performed in three aborted fetus groups, less than 2 months, 2 to 4 months and more than 4 months.
Results: From a total of 100 examined samples, conventional PCR detected the T. gondii infection in 6 (6%) and 2 of the brain and liver fetuses respectively.
Conclusion: This study shows a notable level of infection in goat fetuses, and as a result, T. gondii should be considered an important agent involved in the abortion of goats in the Lorestan province of Iran. On the other side, it is necessary to pay more attention to the risk of transmission of this parasite from farmed animals to humans, especially pregnant women and people with suppressed immune system.
Roksana Farabi, Aylin Javan-Molaei, Esmaeil Farzaneh, Saeid Sadeghieh Ahari, Sara Mostafalou,
Volume 24, Issue 2 (7-2024)
Abstract
Background: Poisoning is one of the common causes of hospital emergency department referrals, especially in adolescents and young people; therefore, knowing the pattern of poisoning will be helpful in identifying risk factors and early detection of poisoning. The aim of this study was to investigate the epidemiology of acute poisoning in adults referred to Imam Khomeini Hospital in Ardabil from 2017 to 2020.
Methods: In this descriptive-analytical and retrospective study, 755 cases related to poisoned patients referred to Imam Khomeini Hospital in Ardabil from 2017 to 2020 were reviewed. The extracted data include ward, gender, age, marital status, place of residence, general status, cause of poisoning, and time of referral, were recorded on the checklist. Obtained Data were analyzed by Chi-square test and SPSS25 software.
Results: The results showed that drug poisoning, opium (opium and its derivatives) and pesticides were the first to third ranks of the most poisoning agents. Most of the poisoned patients were men, married, in the age group of 21 to 30 and living in urban areas. Most of the poisonings were intentional and 33 deaths (4.4%) happened due to poisonings. The cause of poisoning had a significant relationship with age, sex, marital status, place of poisoning (p<0.05) but had no significant relationship with the general condition and time of patients' referral.
Conclusion: Acute poisoning is a major health problem in Ardabil province. The results show that the three agents of drug poisoning, opium and pesticides are the main means of poisoning in adults. Most cases of poisoning occurred in young and adult groups and were in the age range of 21 to 30 years. Poisonings occurred in people aged 31 to 40 were more due to amphetamine. Poisoning with aluminum phosphide tablets had increased compared to before. Consumption of aluminum phosphide is one of the problems of today's societies and it was one of the main causes of death in this research, so it is better to provide necessary measures for management and training for its correct use. Also, by limiting the use of these agents and replacing other methods and techniques, poisoning with these agents can be reduced.
Reza Javanshir, Hossein Kalarestaghy, Ramin Salimnejad,
Volume 24, Issue 2 (7-2024)
Abstract
Background: Premature ovarian insufficiency (POI) is the cessation of ovarian function in women under 40. One of the mechanisms involved in the induction of POI is oxidative stress. This study aims to investigate the effect of caffeic acid on the morphometrical changes of ovarian follicles of POI model mice.
Methods: Thirty-two female mice were randomly divided into 4 groups (n=8): 1) Control group (cont), 2) Caffeic acid group (CAF), 3) Premature ovarian insufficiency group (POI), and 4) Premature ovarian insufficiency + Caffeic acid group (POI+CAF). POI was induced through daily subcutaneous injections of D-galactose (200 mg/kg) for 6 weeks. Caffeic acid (60 mg/kg, intraperitoneal) was injected daily for 4 weeks from 15th day. One day after the last injection, the mice were anesthetized and the ovaries were removed. Then, the morphometric changes of ovarian follicles were examined using hematoxylin-eosin (H&E) staining.
Results: The results showed that D-Galactose-induced POI significantly decreases the diameter of primary, secondary, and antral follicles (P<0.05). Administration of caffeic acid in the POI+CAF group significantly prevented the reduction of follicle diameter (P<0.05).
Conclusion: The results showed that caffeic acid can prevent the reduction of the diameter of ovarian follicles in POI model mice.
Mahzad Yousefian, Ali Mohammadian-Erdi, Afshan Sharghi, Mina Deldadeh Moghaddam,
Volume 24, Issue 2 (7-2024)
Abstract
Background: One of the major challenges in surgery is pain control after surgery. The present study was conducted with the aim of investigating the role of magnesium sulfate in improving the quality of anesthesia in patients who are candidates for appendectomy surgery.
Methods: In this clinical trial study, 42 people in the control group and 42 people in the intervention group were randomly included. For the intervention group, 50 mg/kg of magnesium sulfate was injected and for the control group, the same amount of distilled water was injected as a placebo. After surgery, the patients were examined for pain, nausea and vomiting, anxiety, blood pressure and heart rate, and the satisfaction of the surgeon in terms of muscle relaxation. Collected data were analyzed in SPSS-26 by statistical methods and p<0.05 was considered as significant level.
Results: The average pain of the patients in the first, third, sixth and twelfth hours of the study in the intervention group with 1.4, 2.66, 3.3 and 3.19 were significantly lower than the control group. In terms of relaxation, a significant difference was observed between the two groups in the first, third, sixth, twelfth and eighteenth hours of the study. In the examination of nausea and vomiting of patients, no significant difference was observed between the two groups. During surgery, a significant difference was observed in patients receiving magnesium sulfate compared to the control group in terms of surgeon satisfaction.
Conclusion: Magnesium sulfate was effective in controlling patients' pain and anxiety and surgeon's satisfaction during surgery, but it was not effective in controlling patients' nausea and vomiting.
Roya Houshmandi Khaneghahi, Shahram Habibzadeh, Farhad Pourfarzi, Behnam Mohammadi Ghalehbin,
Volume 24, Issue 2 (7-2024)
Abstract
Background: Toxoplasmosis is a disease caused by an obligate intracellular protozoan called Toxoplasma gondii. Consumption of raw or undercooked meat infected with tissue cysts and consumption of parasite oocysts are considered the main ways of parasite transmission to humans. The most severe complications of toxoplasmosis occur in people who have an ineffective immune system, as well as during pregnancy. Since the awareness of the prevalence of toxoplasmosis in different population groups and geographical areas and the risk factors involved in it, is one of the most important indicators which can be estimated the risk of infection in any society, this study aims to know the extent of prevalence of anti-toxoplasma antibody in serum and some risk factors related to it in females in Ardabil city.
Methods: Three hundred forty nine female of Ardabil city were randomly selected based on the files available in health centers. This number was divided into ten-year age groups with an age range of 1-69 years. These people were invited and included in the study if they agreed. The designed questionnaire was completed and blood samples were taken. Serum samples were tested using an ELISA kit to detect anti-Toxoplasma IgG antibody.
Results: The prevalence rate of anti-toxoplasma IgG antibody in female residents in Ardabil, aged 1 to 69 years was 45%. The prevalence rate was directly related to increasing age. People’s education level had an inverse relationship with the infection rate. Despite the increase in seropositivity, the prevalence rate in people who had contact with cats was not significant. Also, the prevalence rate had a direct and significant relationship with increasing BMI.
Conclusion: The seroprevalence of anti-toxoplasmosis antibody in female people in Ardabil is equal to 45% and is high compared to the world estimates. 70-75% of people of marriageable age are seronegative and are at risk of contracting acute toxoplasmosis during pregnancy, which requires appropriate preventive health policies.
Homa Akhavan Aghghaleh, Najmeh Ranji, Hadi Habibollahi,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Gastric cancer is a type of malignancy that affects the digestive system. Symptoms of gastric cancer are often hard to detect in the early stages, and become more noticeable only after cancer cells have grown inside the stomach wall and spread to other parts of the body. The genetic code of the cancer cells is located within the genome. Synonymous and non-synonymous mutations are two subgroups of SNP codes. The purpose of this study was to investigate the correlation between genetic variants and susceptibility to gastric cancer in Ardabil province.
Methods: The distribution of variants in the genomic DNA of 150 volunteers from the general population of Ardabil was determined using whole exome sequencing. Databases such as Iranome, Alfa, GnomAD, and 1000G were used to compare allele frequencies. After calculating the frequency of variants using standard methods, Pearson correlation was utilized to statistically analyze their correlation with age-standardized incidence rates (ASRs) for gastric cancer in related populations. A p-value below 0.05 was deemed statistically significant for all analyses. Statistical analysis was conducted using IBM SPSS Statistics version 25.
Results: Significant differences in 19 variants , including rs10061133, rs1050631, rs12220909, rs12983273, rs1695, rs2274223, rs2292832, rs2294008, rs2505901, rs2976391, rs33927012, rs3744037, rs3745469, rs4789936, rs4986790, rs4986791, rs6194, rs63750447, and rs6505162 were found between the general population of Ardabil and other populations. A statistically significant difference was observed and reported at the 0.05 and 0.01 levels in relation to the correlation between the desired variants.
Conclusion: Results suggest a correlation between gene variants in carcinogenesis, highlighting the need for functional studies on gene cooperation in gastric cancer development.
Hossein Kalarestaghi, Mir-Mahdi Hosseini, Ramin Salimnejad,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Liver aging is an important risk factor for chronic liver diseases. Oxidative stress is considered a common pathological mechanism for liver aging. This study aims to investigate caffeic acid's effects against liver injuries in a D-galactose-induced mouse aging model.
Methods: Forty male mice were randomly divided into 5 groups (n=8): 1) control (Con); 2) Sham; 3) caffeic acid (CA), 4) aging (Ag), and 5) aging+ caffeic acid (Ag+CA). The aging model was induced through daily intraperitoneal (i.p) injections of D-galactose (300 mg/kg) for 6 weeks. Caffeic acid (60 mg/kg, i.p.) was injected daily for 6 weeks. One day after the last injection, the mice were anesthetized, blood was withdrawn (for liver enzymes evaluation) and the liver was removed. The histopathological changes in the liver were examined using hematoxylin-eosin staining.
Results: The results showed that D-galactose-induced aging significantly increases the level of liver enzymes (AST, ALT and ALP) as well as liver tissue destruction compared to the control and sham groups (p<0.05). Treatment with caffeic acid in the Ag+CA group significantly decreased the level of liver enzymes and tissue damage index (p<0.05).
Conclusion: The results indicated that caffeic acid can reduce the destructive effects of D-galactose-induced aging in liver tissue.
Faranak Hasanpour, Saber Zahri, Arash Abdolmaleki, Asadolah Asadi,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Tissue engineering, by designing biological scaffolds and imitating the extracellular environment, helps the growth and proliferation of cells and plays a key role in replacing and repairing damaged tissues. In recent years, the addition of nanoparticles, such as carbon quantum dots, to biological scaffolds has received attention. In this research, the synthesis of polycaprolactone scaffolds containing carbon quantum dots and the investigation of biocompatibility effects and their protection have been discussed.
Methods: Carbon quantum dots were synthesized using the pyrolysis method, and polymer scaffolds containing carbon quantum dots were prepared by the electrospinning method. The physical and chemical properties of the scaffold were evaluated by scanning electron microscopy and FTIR spectroscopy. The scaffolds' biocompatibility and antioxidant properties were measured by the MTT method.
Results: Examination of the morphology and chemical showed the appropriate porosity of the scaffold containing carbon quantum dots. The MTT assay significantly enhanced stem cell viability on scaffolds incorporating carbon quantum dots. Furthermore, these scaffolds exhibited a significant protective effect against oxidative stress.
Conclusion: This study showed that the polycaprolactone scaffold containing carbon quantum dots, with high biocompatibility and suitable antioxidant properties, provides an effective substrate for tissue engineering and cell protection under oxidative stress conditions.
Azam Shiasi, Ramesh Monajemi, Marzieh Tavalaee, Mohammad Hossein Nasr Esfahani,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Varicocele is one of the common causes of male infertility, associated with increased oxidative stress and damage to sperm DNA. This study aims to investigate the effects of L-cysteine, taurine, and vitamin B6 (LTB) on spermatogenesis, sperm function, and enzymes involved in the trans-sulfuration pathway in the testes of varicocele-induced rats.
Methods: Male Wistar rats (180–220 g) were randomly divided into five experimental groups: the control group (no intervention), the sham group (simple laparotomy), the varicocele group (V), the LTB-treated control group, and the LTB-treated varicocele group. Evaluations included sperm parameter assessments, testicular histology analysis, measurement of testosterone levels, vitamin B6 levels, various amino acids, and the expression of enzymes in the trans-sulfuration pathway at the protein level using the Western blot method.
Results: The study revealed a significant reduction in sperm quality parameters and sperm function (p<0.05) in the varicocele group compared to the control and sham groups. Additionally, enzymes involved in the trans-sulfuration pathway were reduced in the varicocele group compared to the sham group, although the difference was not statistically significant. Plasma B6 levels in the varicocele group showed a significant decrease compared to the control group (p<0.05). Supplementation with LTB improved the negative effects of varicocele on spermatogenesis and sperm function.
Conclusion: Antioxidants may play a role in improving varicocele. Using amino acids and vitamins involved in the one-carbon cycle and the trans-sulfuration pathway can enhance the testicular antioxidant system and counteract the negative effects of varicocele. These findings highlight the need for further studies and the potential for higher doses or longer durations of antioxidant supplementation to achieve better therapeutic effects.
Narges Karimi, Shahla Farzipour, Fatemeh Mirershadi, Samira Shahbazzadegan,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Elective abortion is one of the factors affecting the decline in population growth and fertility rates and is a complex issue in the field of reproductive health. Given that elective abortion is prohibited in Iran, there are no accurate statistics on it. This study aimed to investigate the frequency, causes and methods of elective abortion and demographic characteristics of related women referring to Alavi Educational and Medical Center in Ardabil city from 2022 to 2023.
Methods: This descriptive, cross-sectional study was conducted on women referred to Alavi Hospital in Ardabil for elective abortion from November 2022 to March 2023. Data were collected through referrals to women's records, interviews, and questionnaires. Data analysis was carried out using SPSS-16 and descriptive statistics.
Results: 116 women were referred to Alavi Hospital in Ardabil for elective abortion. The largest number of women (50.9%) was in the age group of 25-34 years and most of them (79.3%) lived in urban areas. The gestational age of 78.4% of them was less than 12 weeks. In terms of education, 41.4% of women had an intermediate level of education. 62.9% of women used natural contraception and 87.1% used the misoprostol method for abortion. Desire to Limit childbearing (20.7%) was the main reason for abortion. 54.3% of women had no history of previous abortion.
Conclusion: Considering that the desire to limit childbearing was the main reason for abortion, and that the most studied people had no history of abortion and had average to low income and job satisfaction, it can be concluded that cultural, economic, and social issues are involved in abortion.
Ahmad Salimi, Zhaleh Jamali, Mohammad Shabani, Deniz Bayrami, Amin Ashena Moghadam,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Ifosfamide-induced kidney damage is an important toxicity in children and adults undergoing chemotherapy. Studies have previously demonstrated that toxic metabolites of ifosfamide, such as acrolein, are associated with depletion of antioxidants, oxidative stress, and mitochondrial impairment, which may predispose the kidney to ifosfamide toxicity. Plant-derived active compounds, such as chrysin, found in fruits and vegetables, are renowned for their antioxidant and mitochondrial protective effects against toxicity-related mitochondrial damage and oxidative stress.
Methods: In this work, the protective effects of chrysin on ifosfamide-induced nephrotoxicity in male Wistar rats were investigated using biochemical, histopathological, and mitochondrial approaches. The animals were randomly divided into four groups: control, ifosfamide, ifosfamide + chrysin, and chrysin groups. Chrysin (25 mg/kg, i.p. daily) was administered to rats for 2 consecutive days, and ifosfamide (500 mg/kg, i.p.) was administered on the third day.
Results: The data demonstrated that pretreatment with chrysin significantly increased mitochondrial succinate dehydrogenase activity and protected against mitochondrial swelling, mitochondrial membrane potential loss, reactive oxygen species formation, lipid peroxidation, and glutathione depletion (p<0.001). Histopathological results showed that chrysin had protective effects and reduced histopathological abnormalities caused by ifosfamide.
Conclusion: These observations confirmed that chrysin pretreatment protects the kidneys against mitochondrial dysfunction, oxidative stress, and histopathological abnormalities induced by ifosfamide.
Saghar Jafari-Ramedani, Fereshteh Hasanpour, Alireza Mohammadnia, Farzad Khademi, Aida Alinezhad,
Volume 24, Issue 3 (10-2024)
Abstract
Background: The Gram-negative pathogen Pseudomonas aeruginosa (P. aeruginosa) is a common cause of hospital-acquired infections. This bacterium is continuously increasing its resistance to commonly used antimicrobial drugs, posing significant challenges for clinical treatment. Therefore, this study aimed to investigate the trend of antibiotic resistance in P. aeruginosa from 2019 to 2023 in hospitals in Ardabil city.
Methods: This cross-sectional descriptive study utilized 200 clinical isolates of P. aeruginosa obtained from urine, respiratory, wound, blood, and cerebrospinal fluid samples of patients who visited Ardabil hospitals between June 2019 and May 2023. The sensitivity and resistance of P. aeruginosa isolates to antibiotics-including piperacillin, piperacillin / tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem, amikacin, tobramycin, netilmicin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and colistin-were assessed using the disk diffusion and agar dilution methods.
Results: Over a period of 4 years, the resistance of P. aeruginosa to various antibiotics was observed as follows: piperacillin 45.5%, piperacillin/tazobactam 31%, ceftazidime 44%, cefepime 46%, aztreonam 12%, imipenem 67.5%, meropenem 52%, amikacin 43%, tobramycin 45.5%, netilmicin 39.2%, ciprofloxacin 55.5%, ofloxacin 62%, norfloxacin 53.5%, levofloxacin 55.5%, and colistin 9%. It is worth mentioning that the trend of antibiotic resistance in P. aeruginosa to all tested antibiotics increased during the first and second years, decreased in the third year, and then experienced a significant increase again in the fourth year. Throughout this period, the emergence of multidrug-resistant (MDR) strains of P. aeruginosa has also been on the rise.
Conclusion: The present study confirmed that the overall trend of resistance to various antibiotics among P. aeruginosa strains isolated from patients in Ardabil is on the rise.
Mahshid Khajavi, Elham Safarzadeh, Faraz Mahdizadeh, Shokofeh Banaei,
Volume 24, Issue 4 (1-2025)
Abstract
Background: 5-fluorouracil is one of the chemotherapy drugs that has destructive effects on body tissues such as the heart, liver, kidney, brain and reproductive system in humans and animals. Reproductive dysfunction is considered to be an important side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the effects of Oleuropein (OLE) against 5-FU-induced ovarian toxicity.
Methods: 24 adult female rats (weighing 200-225 g) were randomly divided into 4 groups (N= 6) with a treatment period of 14 days including the control group, 5-FU (100 mg/kg/week, IP), OLE (200 mg/kg/day, IP), 5-FU + OLE group, administrated 5-FU (100 mg/kg/week) with OLE (200 mg/kg/day). After treatment, blood samples were collected for the measurement of female sexual hormones, and ovarian samples were taken for histological assessment.
Results: 5-FU significantly decreased female sexual hormones. Also, it caused tissue damage in the ovary, as 5-FU-administered rats had degenerated follicles and hemorrhage. While the administration of OLE significantly increased the estradiol, and progesterone (p< 0.05) levels and improved ovarian pathological changes.
Conclusion: Oleuropein reduces 5-fluorouracil –induced reproductive toxicity in female rats.
Saeed Mashahadi, Shahram Habibzadeh, Gholamreza Hamidkholgh, Amirahmad Arabzadeh, Elham Safarzadeh,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-COV2) caused more than one million deaths in the first 6 months of the pandemic and caused huge economic and social problems internationally. An effective vaccine is certainly essential to prevent further deaths. One of the vaccines used in the control and prevention of the disease was the Sputnik V vaccine, and in this study, the side effects of the Sputnik V vaccine in vaccinated individuals in Ardabil province were evaluated.
Methods: In this retrospective descriptive cross-sectional study, the side effects observed in individuals vaccinated with the "Sputnik V vaccine" in the first and second doses were examined. Demographic information such as age and gender, history of drug use, general side effects including respiratory, gastrointestinal and neurological side effects and local side effects such as pain, swelling, redness, muscle spasms, as well as the time of onset of side effects and the duration of side effects were recorded for all vaccinated individuals. After collection, the data were analyzed using statistical methods.
Results: Among general complications, body aches were the most common with 65.4% and palpitations were the least common with 1.71%. In terms of respiratory complications, sore throat and burning sensation in the throat were the most common with 8.3% and runny nose was the least common with 3.9%. Among gastrointestinal complications, nausea was the most common with 13.4% and vomiting was the least common with 2.0 %. In terms of local complications, injection site pain was the most common with 50.5% and armpit pain on the same side of the injection was the least common with 3.9%.
Conclusion: Side effects of the Sputnik V vaccine were usually mild to moderate and acceptable and tolerable.
Rezvan Afshar, Masoud Rahmati, Rahim Mirnasouri,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Given the secretion of myokines from muscle tissue during exercise and their relationship with muscle strength development, the present study aimed to investigate the relationship between muscle strength and serum levels of irisin, brain-derived neurotrophic factor, myostatin and follistatin in inactive men and women following 12 weeks of strength training.
Methods: In this quasi-experimental study, 10 women (age: 37.6±6.09 years, weight: 80.5±20.76 kg) and 20 men (age: 39.6±6.05 years, weight: 84.89±5.67 kg) voluntarily participated. The subjects performed 12 weeks of strength training, 3 sessions per week, with an intensity of 65 to 80% of maximum strength. Blood samples were taken for measurement of irisin, brain-derived neurotrophic factor, myostatin, and follistatin by ELISA.
Results: Strength training significantly increased serum irisin, serum BDNF, follistatin and significantly decreased myostatin and fat percentage in both male and female groups (p≤0.05). There was also a positive and significant relationship between lower body strength and irisin in women (p=0.040) and upper body strength in women and BDNF (p=0.038). The results in the male group showed a significant and positive relationship between serum irisin levels with upper and lower body strength and follistatin with lower body strength (p≤0.05).
Conclusion: According to the results of the study, strength training in inactive individuals reduces serum levels of myostatin , increases secretion and serum levels of irisin, BDNF, follistatin, and increases muscle strength.
Ali Eskandari, Atabak Sedigh-Namin, Shafagh Aliasgarzadeh, Sara Jalalijivan, Saeid Sadeghieh Ahari,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Vasculitis is the inflammation of blood vessel walls, which may lead to vessel damage, narrowing, or occlusion. To better understand the impact of the environment and social factors on the development of vasculitis, more studies need to be conducted in different regions. Early diagnosis based on the prevalence of vasculitis helps in the management and treatment of these patients and prevents irreversible damage, which highlights the importance of diagnosing Vasculitis diseases.
Methods: In this cross-sectional, descriptive study, we evaluated 152 patients who were referred to the Rheumatology Clinic of Imam Khomeini Hospital of Ardabil during the years 2018-2023. The required information was collected by reviewing the patients' medical records in the hospital archive. The relevant information was entered into SPSS software version 22 and evaluated based on the research objectives.
Results: Data from 152 patients were analyzed. Behcet's disease (68.2%) and Wegener's granulomatosis (11.3%) were the most frequent diagnoses. Female patients comprised 53% of the group, with an average age of 36.8 years. Giant cell arteritis patients had the highest average age, while Behcet's patients had the lowest. Most patients resided in Ardabil city and were housekeepers or agricultural workers. Common symptoms included carotid disease and pulse reduction in Takayasu's arteritis, temporal tenderness in giant cell arteritis, weakness and myalgia in polyarteritis nodosa, shortness of breath in Churg-Strauss syndrome, hemoptysis in Wegener's, and mouth sores in Behcet's. ESR and CRP levels were highest in giant cell arteritis compared to other vasculitis types.
Conclusion: Behcet's and Wegener's were the most common vasculitis types. Symptoms varied by disease but often included general signs like fever and myalgia. Elevated ESR and CRP were consistent across cases, with imaging and pathology being key diagnostic tools
Zahra Kargar Dolatabadi, Abdossaleh Zar, Sara Zare Karizak, Rouhollah Ranjbar,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Various signaling pathways are involved in causing hypertrophy in different organs of the body. One of these important pathways is the mTOR signaling pathway, which, as a key regulator in cellular growth and metabolism processes, plays an important role in muscle hypertrophy and kidney function. The aim of the present study was to investigate the effect of resistance training and Spirulina supplementation on the expression of IGF-1, AKT, Rheb, and TSC2 genes in male rats.
Methods: 32 male Sprague Dawley rats, 3 months old and weighing 150 ± 20 g, were randomly assigned to four groups: resistance training + spirulina supplement, resistance training, spirulina supplement, and control. Spirulina was orally administered to rats in the spirulina and resistance training plus spirulina groups at a dose of 200 mg/kg body weight per day for eight weeks. The resistance training protocol consisted of eight weeks of ladder climbing to a height of one meter. The expression levels of IGF-1, AKT, Rheb, and TSC2 were measured using Real-time PCR.
Results: The expression levels of IGF-1 (p<0.001), AKT (p<0.0001) and Rheb (p<0.0001) genes showed a significant increase in the exercise + supplement group. While the expression of TSC2 gene was significantly decreased in the exercise + supplement group (p<0.0001).
Conclusion: The findings indicate a positive effect of resistance training and Spirulina supplementation on the expression of IGF-1, AKT, Rheb, and TSC2 genes in kidney tissue.
Samira Shahbazzadegan, Mohammad Ali Mohammadi, Iraj Feizi, Faredeh Mostafazadeh, Rana Beheshti,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Fertility is one of the important challenges of women with breast cancer. The incidence of breast cancer among women aged 20 to 49 is gradually increasing, and at the same time, there is evidence that the age of first pregnancy is also increasing, and this requires attention to these issues. Therefore, the present study was conducted with the aim of determining the fertility desire in women with breast cancer in Ardabil in 2024.
Methods: This descriptive study was conducted on women with breast cancer in Ardabil city using a census method. After obtaining the code of ethics and receiving an introduction letter and informed consent from the participants, data were collected using a demographic information questionnaire and a specific fertility desire questionnaire for women with breast cancer. Data analysis was performed using SPSS software using descriptive and analytical statistics.
Results: Data from 180 breast cancer patients were analyzed. The mean fertility desire was 37.86 ± 11.86, which was significantly lower than the criterion value (45) (p<0.001). The mean score of the disease control dimension was 17.81, which was significantly higher than the criterion value (14). The scores of the pregnancy risk, social support, and happiness dimensions were significantly lower than the criterion value (p<0.001). There was a significant relationship between the number of children and the method of adjuvant therapy with fertility desire (p<0.01 and p<0.04, respectively).
Conclusion: Fertility desire in women with breast cancer was low. The reason for the low desire to be fertile was related to the low disease control, social support, and happiness in patients, while it was not related to the risk of the disease. There was a relationship between the desire to be fertile with the treatment method and the number of children and age. The desire to be fertile was higher in women who used chemotherapy alone than in women treated with both chemotherapy and radiotherapy. Also, the desire to be fertile was higher in women with fewer children than in women with more children, and also women with younger age had a higher desire to become pregnant. The study results showed that young women with breast cancer need more attention regarding disease control, social support, and happiness.
Soheila Derisavy Jorfian, Ulduz Zamani Ahari,
Volume 24, Issue 4 (1-2025)
Abstract
Background: No study has been conducted on the state of occupational stress and its relationship with oral and dental tissues in nurses, so in order to fill the scientific and research gap in this field, the present study was conducted with the aim of investigating the state of occupational stress and its relationship with oral and dental tissue damage in nurses of Ardabil University of Medical Sciences in 2023.
Methods: In this descriptive-analytical study, 338 nurses working in different departments of public hospitals in Ardabil city were examined. The research tools in the study included 2 questionnaires: 1- Demographic questionnaire, 2- Occupational stress questionnaire of Toft and Anderson nurses and a checklist of the condition of oral and dental tissues related to stress. Questionnaires and checklist after collecting Data were entered into SPSS version 24 software and analyzed with logistic regression. A significance level of less than 0.05 was considered.
Results: The results of the survey showed that the occupational stress of Ardabil nurses was at a moderate level in most cases (86.3%). The most problems in the state of oral and dental tissues related to stress in nurses are related to dry mouth (33.6%), mouth sores (23.5%), jaw pain after waking up in the morning (23.1%) and the least case was loose teeth (2.9%). Also, the results showed that occupational stress of nurses has a significant effect on teeth wear, difficulty in chewing and the presence of broken teeth apart from physical trauma (p<0.05).
Conclusion: The occupational stress of the investigated nurses was at a medium level, which caused problems such as tooth wear, difficulty in chewing, and the presence of broken teeth in addition to physical trauma.
Hamidreza Azari- Dastjerdi, Mohammad Javad Saeedi Borujeni, Mehdi Abrishami, Nasim Jafari Pozve,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Sinonasal polyposis is a common respiratory disorder that reduces the quality of life of patients and causes secondary complications. The present study was designed to compare the severity of nasal septal deviation in patients with recurrent and non-recurrent sinonasal polyposis.
Methods: The present study is a case-control study conducted between 2018 and 2023 in the ENT Department of Gharazi Hospital, Isfahan. 80 patients with sinonasal polyposis were divided into two groups of 40: control (patients with non-recurrent sinonasal polyposis) and case (patients with recurrent sinonasal polyposis). For this purpose, the anatomical structures of the nose and paranasal sinuses were evaluated in the preoperative CT scan sample, and the severity of nasal septal deviation was calculated using OsiriX software.
Results: In the recurrent group, the mean angle of nasal septum deviation was 11.65±4.52 degrees and in the non-recurrent group, it was 9.7±3.76 degrees. Based on the independent t-test, there was a statistically significant difference between the two groups (p=0.039). The results also showed that asthma (p=0.043) and smoking (p=0.039) caused significant changes in the studied groups.
Conclusion: The results showed that recurrent sinonasal polyposis causes severe septal deviation more often than non-recurrent. A definitive statement on this issue requires a more detailed study with a larger sample size and also an investigation of the risk factors involved in the recurrence of polyposis.
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