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Showing 62 results for Ast
Mahdi Arzanlou,
Volume 10, Issue 2 (6-2010)
Abstract
Back ground and aim: Cerebral phaeohyphomycosis in humans is caused by fungal agent which belongs to black yeasts. The disease is apparently restricted to Middle East been reported from Saudi Arabia, occupied Palestine and Qatar. The disease has not been recorded from Iran yet or its existence has not been noticed. Ramichloridium mackenziei is responsible for this disease, which belongs to fungal order chaetothyriales. Members of this order are mainly opportunistic pathogens on humans and animals causing a wide range of infections such as chromoblastomycosis (cutaneous, subcutaneous) and cerebral phaeohyphomycosis. Species recognition and delineation in members of this order is based on morphological features of asexual stage (anamorph). This order encompasses several genera such as Ramichloridium, Rhinocladiella, Exophiala, Veronaea, Cladophialophora. Some members of this order are morphologically similar to plant pathogenic or saprotrophic species and there is no clear-cut morphological differences among these genera. Accurate identification of human pathogenic species in both clinics and natural ecological niches will play important role in our understating on ecology of these fungi. Materials and methods: In present study, 24 isolates belonging to 15 species from three genera viz., Ramichloridium, Rhinocladiella and Veronaea were subjected to morphological and molecular examinations. Morphological features were evaluated on malt extract agar, using a slide culture technique. Phylogenitc relationship among isolates was inferred based on sequence data from two genomic regions of ribosomal DNA including partial sequences from ITS-rDNA and LSU-rDNA. Results: Phylogeny inferred from DNA sequence data placed isolates in two groups. Clade one included Rhinocladiella and Veronaea together with Ramichloridium mackenziei and R. fasiculata, R. anceps and Rhinocladiella basitona which all belong to the order Chaetothyriales. The second clade included type species of genus Ramichloridium (R. apiculatum) together with other plant pathogenic Ramicholridium species which belong to the order Capnodiales. Putting together DNA sequence data, ecology and morphology, Rhinocladiella is an appropriate genus to accommodate Ramichloridium mackenziei. Conclusion: taxonomic and phylogenetic position of Ramichloridium mackenziei is ascertained in Chaetothyriales. Combination of DNA data set together with morphology and ecology is indispensable in identification of human pathogenic Chaetothyriales. Current work is good starting point towards studying importance and diversity of these fungi in Iran.
Kamaladdin Hassanzadeh , Parisa Yavari Kia , Vahid Emdady, Seyedkazem Maden ,
Volume 10, Issue 3 (9-2010)
Abstract
Background and Objectives: Three major semen parameters that involves on male infertility are sperm count, motility and morphology. In 50% of couples referring to physicians, because of infertility, male factor, solely or accompanying with female factor is responsible of infertility. Some of drugs are used to improve the semen parameters. The goal of this study was to study the effect of pentoxifylline on semen parameters (count, motility, morphology, volume of semen). Methods: Sixty one patients with impairment in semen parameters were selected and semen samples requested from each participant for analysis before treatment. Then patients were treated with pentoxifyllin, 400 mg three times a day, for three months. After that we took semen specimens again and analyzed them. Results: Mean total sperm count in case group before treatment with PF was (17 millions) and after treatment with PF reached to (21 millions). In 68.9% of patient, Sperm count increased (p<0.001) Mean motile sperm percent in case group before treatment with PF was 19.42% and After treatment with PF reached to 28.78% and 88.52% of patient this parameter increased (p<0.001). Parameter motility showed the most important after treatment. Mean normal morphology of sperm percent in case group before treatment with PF was 24%and after treatment with PF reached to 26.39% and in 32.8% of patient this parameter increased (p<0.001).Mean semen volume in this group before treament with PF was 1.95ml and after treament with PF reached to 1.93 ml. There was no significant variation in semen volume after treament with PF. (p=0.321) Conclusion: Results show that Pentoxifylline has significant efficacy for increasing sperm count, motility and morphology correction (specially for sperm motility). Considering that oral PF is safe and cheap, with easy application, we can use it for improving semen parameter’s quality before performance ART.
Mohammad Mazani , Shabnam Javadi , Jafar Bashiri , Abbas Naghizadeh, Amir Mansoor Vatankhah,
Volume 10, Issue 3 (9-2010)
Abstract
Background and Objectives: Gastric cancer is the most incident disease in Iran that leads to death. This study was designed to evaluate the oxidative and antioxidative status in patients with gastric cancer by detecting paraoxonase 1 and arylesterase activities together with the level of malondialdehyde. The purpose of the present investigation was determination of Paraoxonase /Arylesterase activity and malondialdehyde (MDA) levels in the serum of patients with Gastric cancer. Methods: In a case-control study, 20 subjects who diagnosed as gastric cancer individuals that referred to Ardabil Aras Clinic were selected from 2008 up to 2009. The case groups were matched with control group (30 subjects). Arylesterase and paraoxonase activities of paraoxonase-1 (PON-1), MDA levels and lipid profile were determined spectrophotometrically in serum of subjects. Results: Upon matching of case and control groups, paraoxonase and arylesterase activities in patients with gastric cancer showed to be significantly lower than healthy subjects (190 ± 68.95 IU/L vs 258 ± 68.59 IU/L, 30.5 ± 28.4 U/L vs 284.23 ± 163.2 U/L respectively, P ≤ 0.001). Standardized activities of paraoxonase and arylesterase of case group were lower than controls (P ≤ 0.001). MDA levels have revealed significant increasing in cases than controls. In present study, HDL cholesterol and triglyceride levels were found to decrease in patient sera too, but the levels of total cholesterol and LDL cholesterol didn’t show to be different between two groups. Conclusion: It was concluded that in patients with gastric cancer, oxidative stress was raised by attenuation of antioxidant system and oxidant levels rising.
Sousan Salimipormehr , Noorosadat Kariman, Zohreh Sheykhan, Hamid Alavimajd,
Volume 10, Issue 4 (12-2010)
Abstract
Background & Objectives: Breast cancer is one third of all kinds of cancers and the second reason of death in women. Prevention and screening can decrease affection and death rate. The aim of this study was to determine the breast cancer screening tests performance and affecting factors in women referred to Ardabil’s Health and Medical Centers in 2009 . Methods: In this descriptive-analytic study, 300 women referring to Ardabil’s Health and Medical Centers were chosen by multistage sampling. The information was collected through the researcher-made questionnaire including two parts: Knowledge and Attitude questions and a form about demographical characteristics, family, social and economic factors, risk and women-midwifery factors. For analyzing the data, SPSS software version 16, and descriptive and deductive statistic tests were used . Results: The percentage of screening tests including self-examination, clinical examination and mammography consequently were 4%, 4.7% and 3.7%. There was significant relationship between breast self-examination and education (p =0.003), knowledge (p =0/002) and attitude (p=0.004). No significant difference was observed between insurance status and history of hormone therapy and breast cancer screening tests. Conclusion: In regard to the low rate of breast cancer screening conducted and determining the affecting factors, the appropriate educational programs and interventional research are emphasized .
Reza Mahdavi , Ali Nemati , Eiraj Feizi, Mojtaba Amani , Hosein Alimohammadi Asl, Mohammad Mazani M, Phd4; Nagizadeh Bagi , Abbas , Ali Shadman , Reza Alipanah Mogadam, Asghar Pirzadeh, Mousa Ghayour Nahand,
Volume 11, Issue 2 (6-2011)
Abstract
Background & Objectives: Consumption of ω3 fatty acids supplementation inhibits oxidative stress injury, increases activity of antioxidant enzymes and decreases lipid peroxidation in gastric cancer patients. In this study, we examined effects of ω-3 fatty acid intakes on oxidative stress in gastric cancer patients undergoing chemotherapy. Methods: This double blind clinical trial study was conducted on 30 adult patients (15 cases and 15 controls) with gastric cancer during chemotherapy in Ardabil city in 2010. Case and control groups were selected by randomized allocation. Three grams ω -3 fatty acid supplementation (1.8 g EPA & 1.2 g DHA in 10 g fish oil) and placebo were given case and control groups for 45 days, respectively. Anthropometric indices (weight, height & BMI) were measured. Blood samples were taken and then biochemical factors including triglycerides, total cholesterol, HDL and LDL cholesterol, MDA, and total antioxidants were evaluated at the beginning, middle and end of the study . The data were analyzed by using Paired sample t-test, Independent sample t-test and repeated measures test. Results: MDA, Weight and BMI of omega group after intervention were significantly more than control group at the end of the study (p<0.05). Weight and BMI were decreased but serum MDA was significantly increased in control group during the study (p<0.05). Weight, BMI , and total antioxidants were significantly increased in omega group during day 30-45, (p<0.05). There were no significant differences in other biochemical factors at the end of study. Conclusion: The present investigation shows administration of ω3 fatty acid supplements to gastric cancer patients during chemotherapy increases the total antioxidants capacity and prevents the enhancement of oxidative stress.
Kamal Yavari,
Volume 11, Issue 4 (12-2011)
Abstract
Background & Objectives: Antibody-based radiopharmaceutical drugs are the great current interest in imaging and radiotherapy of cancers, and provide an important tool for target-specific delivery of radionuclides to specific antigens in the diseased tissues. The monoclonal antibody avastin binds, neutralizes VEGF (Vascular endothelial growth factor) and blocks VEGF-induced angiogenesis in tumor tissues. In this study, the complex of avastin and beta particle was investigated as a first step in the production of a radiopharmaceutical drug. Methods: Antibody of avastin was prepared and purified. The antibody was conjugated with freshly prepared DOTA-NHS and then labeled with 153Sm-samarium chloride (185 MBq). The efficiency and in vitro stability of antibody labeling were determined using thin layer chromatography. The integrity of the radiolabeled antibody was checked by SDS-PAGE (Sodium Dodecyl Sulfate PolyAcrylamide Gel Electrophoresis) protocol. Biodistribution study of 153Sm-DOTA –Avastin was performed in BALB/c mice at 2, 24, 48 and 72 hours after injection. Results: The efficiency of antibody labeling was more than 98%. The in vitro stability of the labeled product in human serum after 120h was 83 ±2%. There was no fragmentation in the labeled antibody during SDS-PAGE protocol. The highest (%ID/g) was observed in the liver, lungs and kidneys. Conclusion: The monoclonal antibody avastin against angiogenesis was effectively radiolabeled with 153Sm. The Biodistribution study showed that it has a high specificity to accumulation in tissues with enriched blood vessels.
Mosaddeg Jabbari , Mahshid Talebi-Taher, Mostafa Ariafar,
Volume 12, Issue 2 (6-2012)
Abstract
Background & Objectives: Contrast media-induced nephrotoxicity is one of the most common causes of acute renal failure and promotes both increased morbidity and greater healthcare costs. several mechanisms by which contrast media induces renal injury. These include renal vasoconstriction and direct effect of the contrast agents and reactive oxygen metabolites production. L-carnitine facilitates the transfer of long-chain fatty acids into the mitochondria. By this mechanism carnitine maintains low pools of fatty acid (acyl)-coenzyme a compounds, which are potentially toxic. However some of the actions of L-carnitine may be opposite to the toxic effects of contrast media. This study examined wheter administration of L-carnitine ameliorates contrast media-induced renal injury in rats. Methods : Fifty Sprauge-Dawley rats, weighting 140-230 gr were assigned to one of five treatment groups: group A(control) rats were given normal saline injections daily for 4 consecutive days, group B rats were given contrast media(diatrizoate meglumine) 1cc/kg/d, group C rats were given meglumine 1cc/kg/d and carnitine 200mg/kg/d, group D rats were given meglumine 1cc/kg and carnitine 80mg/kg/d, and group E rats were given carnitine 200mg/kg/d. Four days after injections, the rat were killed and their kidneys and blood samples were prepared for pathological and biochemistry examination. Histological scoring of renal cortical pathology was performed. Results: In rats that were given meglumine and no carnitine, renal function tend to be lower than in control group (p=0.001). Among rats injected with meglumine, those given 200mg/kg/d of L-carnitine had higher creatinine clearances at day 4 than the rats not given carnitine (p=00.04). Renal cortical histopathology changes were milder with meglumine and L-carnitine, particularly at 200mg/kg/d. Conclusions: In rats receiving meglumine, daily L- carnitine injections, particularly at 200 mg/kg ameliorates the severity of renal cortical proximal tubular necrosis and maintain greater renal function.
Behzad Davarnia, Parvin Mehdipour , Morteza Arei, Seiyed Saeid Hosseini-Asl ,
Volume 12, Issue 2 (6-2012)
Abstract
Background & Objectives : Breast cancer is among the most frequent disorders among the world. BRCA1 gene was known as a tumor suppressor gene which its loss could be resulted in various destructions in genome. Therefore, changes occurred in its expression level could lead to increasing the effects of oncogene activity on breast cells. Methods : RT-PCR and Q-RT-PCR were used for detecting BRCA1 expression status among 27 primary affected breast cancer patients. The association between its expression status and histopathologic data had been evaluated by statistical assays. Results: Eighty-five percent of patients showed BRCA1 expression and this expression as well as its quantity had significant associations with tumor grade. It was found that tumors with low levels of BRCA1 expression tend to have higher grades. Conclusion : BRCA1 has an important role in suppressing breast tumorogenesis. Corresponding to some of the previous reports, our findings revealed the role of decreasing in BRCA1 expression level as one of the factors which allows tumors to progress.
Ali Nemati, Reza Mahdavi , Eiraj Faizi, Abbas Nagizadeh Baghi,
Volume 12, Issue 3 (9-2012)
Abstract
Background & Objectives: Chemotherapeutics induce side effects in patients with cancer . In animal models the intake of ω3 fatty acids during chemotherapy can increase the impact of chemotherapy drugs and reduce their side effects . This study was aimed to determine the fish oilintake on side effects of chemotherapy drugs in patients with gastric cancer. Methods: A double blind clinical trial study on 30 adult volunteer patients (15 experiments and 15 controls) with gastric cancer was conducted during chemotherapy in Ardabil, Iran, during 2010-2011 . Experimental and control groups were selected by randomized allocation. About 3 grams ω-3 fatty acid supplementation (1.8 g Eicosapentaenoic acid & 1.2 g Docosapentaenoic acid ) and placebo were given to experimental and control groups for 6 weeks, respectively . Then, the results of data were collected at the beginning, 4 and 6 weeks after intervention of ω3/placebo in both groups and analyzed by using descriptive statistics , Chi -Square , Independent sample t-test and Cochran,s Q test. Results: The results of this study showed that there were significant differences of nausea in both group of patients at the end of 6 weeks (p<0.05). A bdominal cramp and nausea significant ly decreased in experimental group during the study (p<0.05). Hair loss , vomiting and diarrhea were reduced in experimental group during the study, but these differences were not statistically significant . There were no significant differences in vomiting , diarrhea and hair loss between two groups at the end of intervention. Conclusion: The present study showed that the intakes of fish oil strongly reduce side effects of chemotherapy drugs such as nausea and abdominal cramp. So, this oil supplementation appears to be harmless and useful in patients with gastric cancer during chemotherapy .
Golamhosein Ettehad, Neda Parastar, Yasamin Pahlavan, Mojtaba Amani,
Volume 12, Issue 3 (9-2012)
Abstract
Background & Objectives: Matrix Metalloproteinases (MMPs), a member of photolytic enzyme family, degrade the extra cellular matrix. MMPs have very important roles in physiological and pathological processes. It has been reported that MMPs concentration increase in malignancies such as stomach, breast, colon, lung, head and neck cancers . Infectionwith Helicobacter pylori is risk factor for gastric cancer and may increase the serum level of MMP-9. The aim of this study was to measure the concentration of MMP-9 in sera of patients infected with H. pylori. Methods: In a descriptive-experimental study, apparent healthy individuals who were refereed for stool and blood tests were randomly selected and their stools and sera samples were collected. A questionnaire containing age, sex, smoking and special diseases in family and type of their diseases was filled for every volunteer. The sera collected immediately after blood sampling and stored in -70oC until used. The concentration of MMP-9 was assessed using ELISA. Stool samples were used for detection of H. pylori antigen. Results: H. pylori positive, negative and equivocal volunteers were 52.38%, 29.76% and 17.85%, respectively. Differences between MMP-9 concentration and H. pylori negative and positive groups were not significant (p=0.25). A significant increase in MMP-9 concentration was found in sera from drivers in compare with housewives. Conclusion: Although there was an increase in serum concentration of MMP-9 in H. pylori infected person, differences between H. pylori negative and positive groups were not significant. The raised concentration of MMP-9 in drivers may arise from difference in their health condition in compare with the housewives. This study suggests that MMP-9 level in serum may increase before initiation of gastric cancer in H. pylori infected individuals.
Gholhmhosein Ettehad, Firouzeh Afshar-Ghahramani, Yasamin Pahlavan, Mojtaba Amani ,
Volume 12, Issue 5 (11-2012)
Abstract
Background & Objectives: Endothelium nitric oxide synthase (eNOS) is a type of enzyme which produces an endogenous factor called nitric oxide (NO). NO plays important role in progress of euplastic diseases. In chronic gastritis, the increased level of NO causes damages to DNA. The aim of present study is to evaluate eNOS concentration in sera of healthy people and those infected by Helicobacter pylori . Methods: The sera and stool specimens from 84 voluntaries (Female: 58.3%, Males 41.6%) were collected. Helicobacter pylori antigen in the stool specimens and eNOS levels in sera were determined using ELISA . Obtained data were analyzed using Excell software. Results : The age range was from 1 to 78 years old (Mean: 30 years old). In terms of special diseases, 70.2% did not have any special diseases, but 29.76% showed at least one special disease, mainly thyroid disease and hypertension. The results for H. pylori stool antigen detection showed that 16.6%, 29.76% and 53.57% of collected specimens were equivocal, Helicobacter pylori negative and positive respectively. Comparison of sera concentrations of eNOS showed that there is no significant change among these three groups. Conclusion : As mentioned in results, the eNOS sera concentrations showed no significant change in Helicobacter pylori positive and negative groups. Albeit the other studies showed the significant increase in serum concentration of Helicobacter pylori positive patient, this controversy may arise from race and variations in Helicobacter pylori pathogenic islands such as those containing VacA and CagA. We propose to conduct a similar study in Ardabil to focus on the pathogenic islands of H. pylori strains in this province.
Behzad Babapour , Shahram Habibzadeh, Mehdi Samadzadeh, Bita Shahbazzadegan, Tahereh Mohammadi, Elham Atighi ,
Volume 12, Issue 5 (11-2012)
Abstract
Background & Objectives: Type 2 diabetes is a major cardiovascular risk factor such as HTN, HLP and smoking. A primary diabetic cardiomyopathy represents a high risk factor for heart failure in the absence of ischemic, valvular and hypertensive heart disease in the diabetic population. CAD is more common in diabetic patients and it is almost asymptomatic. Unquestionably, an early detection of LV damage and CAD is a major goal for the prevention of cardiac disease in the diabetic population. Methods: This study was done as Cross-Sectional method. The study sample consisted of 40 patients with type 2 diabetes mellitus without hypertension and cardiac symptoms (mean age 47 years) who recourse to diabetes clinic of Ardabil Imam Khomeini Hospital during 2009-2010. Left ventricular (LV) function was studied by echocardiography and exercise test using Bruce protocol. Data from the patients were collected and analyzed using SPSS 17 software. Results: All studied cases had a normal systolic function. 22 cases (55%) had diastolic dysfunction and 8 people (20%) had a positive stress test, which all had diastolic dysfunction too. Conclusion: This study showed that an impairment of left ventricular diastolic function occurs early in the natural history of diabetes mellitus and CAD is more common in diabetic patients with diastolic dysfunction.
Shahrbanoo Keihanian , Zahra Fotokian , Maryam Zakerihamidi,
Volume 13, Issue 2 (7-2013)
Abstract
Background & Objectives: Bone metastases induce harmful potential complications on the life of patients. Pamidronate reduces skeletal complications in patients with bone metastases. This study evaluated the effect of Pamidronate on bone pain in cancer patients with bone metastasis. Methods: This was quasi experimental study carried out at Imam Sajjad hospital in Ramsar on 41 patients with malignancy by convenience sampling. In this study 90 mg of Pamidronate was injected intravenously each month for 3 months. Data collection was done through demographic and clinical data questionnaire and visual analog scale . Data of before and after intervention were compared. Statistical analysis was performed using paired t tests, chi-square, Friedman and Wilcox on tests with SPSS version 11.5 and p<0.05 was considered significant. Results: Statistical analysis showed that the most age group (36%) was 50-59 years and the most patients (65.9%) were female. The most common type of cancer was breast (43.9%) and the most common bone metastasis point in the most of patients (65.9%) was diffuse. The most common sites of pain associated with bone were sternum, ischium and T3-T4 vertebrae. Before treatment, the most patients (80.5%) complained of moderate pain whereas after treatment, the majority of them (41.5%) complained of low pain. The results of this study indicated that there was significant difference (p=0.032) between consumption of NSAIDs before and after treatment, but there was no significant difference between consumption of o pium before and after treatment (p=0.096). Conclusion: Pamidronate is effective in prevention of losing bone, reduced pain and analgesic consumption . So i t can be used as primary and routine treatment .
Maryam Ghorbani , Yahia Sokhangouei , Heidar Sadeghi ,
Volume 13, Issue 3 (10-2013)
Abstract
Background & objectives : The surgery of breast cancer like any other surgeries may bring about some problems and complications, which the knowledge of these problems may be an effective way for prevention or dealing with the complications. The motor and sensory impairments in the upper limb of the surgery side necessitate the utilization of the rehabilitation methods. The main purpose of this research was to show the effect of Pilates exercise on range of motion and edema of upper limb in females suffering from breast cancer after going through surgery. Methods: This quasi- experimental study was conducted on 25 patients randomly chosen among the patients referring to Cancer Institute. The designed exercise included five "Mat Pilates" moves which were done for 15 sessions until the patient reached fatigue borderlines. Meantime, the control group was doing routine active exercises in physiotherapy center. The range of motion and edema of upper limb was measured before and after applying the designed exercise. For describing the data, the mean and standard deviation, and for inferential analysis, the correlated T-tests and one way analysis of variance were used in level of significance of 5%, to compare the variants before and after applying the designed exercise. Results: The results showed a significant difference between the flexion, extension, and internal, external rotation of shoulder, flexion and extension of elbow, flexion, extension, supination deviation and pronation deviation of the wrist and forearm before and after experiment in Pilates group. While in the control group, flexion, extension, internal and external rotation of shoulder, flexion and extension of elbow, and flexion of wrist showed a significant difference before and after the experiment. Conclusion: The use of Pilates exercise after mastectomy surgery can increase the range of motion of the upper limb in the involved side of the patients, and decrease the edema, and improve the motion of the upper limb.
Homeira Nasiri Rineh , Ferangis Khanpour,
Volume 13, Issue 3 (10-2013)
Abstract
Background & Objectives: Obesity is an important risk factor for many diseases and hormonal and metabolic factors have a great impact on its development. The aim of this study was to investigate the relationship between leptin and growth hormones with anthropometric indices and blood glucose in healthy men. Methods: This study is a cross-sectional study on 30 healthy adult men aged 18-49 years in Tonekabone city during 2011-2012. Samples were randomly selected and information on anthropometric parameters (waist circumference, body mass index and waist/hip ratio), fasting blood sugar, serum levels of leptin and growth hormones were recorded and blood sampling was performed After 12 hours of fasting (at 8 am). Data were analyzed using software SPSS 15 by non- parametric Mann – Whitney and Spearman test s and multiple regression analysis. Results: Serum leptin levels were negatively correlated with serum level of growth hormone ( P<0.05) and positively related to body mass index ( P<0.01) , waist circumference ( P<0.01) and the body weight ( P<0.05). Inverse relationship between serum growth hormone levels with age and fasting blood glucose were observed (P<0.05). Serum levels of leptin were significantly higher in overweight and obese than normal weight subjects (P<0.01) and mean leptin levels in subjects with central obesity ( waist circumference≥94cm) were significantly higher than men without central obesity (waist circumference<94cm) (P<0.01). Conclusion: This study showed that growth hormone level was negatively correlated with serum level of leptin. Low serum growth hormone and high serum leptin levels were associated with obesity and upper body fat distribution. Obesity and abdominal obesity are also associated with increased risk of metabolic syndrome
Parsa Yousefi Chaijan, Farshad Jafari , Mohammad Rafiei , Hamid Sheykholeslami,
Volume 13, Issue 3 (10-2013)
Abstract
Background &Objectives: Antiemetic drugs can be used in complicated cases of vomiting secondary to gastroenteritis. There is no previous study dealing with the use of pyridoxine in treatment of vomiting in pediatrics. This Studyintendsto review the effects of intravenous pyridoxine on control of gastroenteritis related vomiting. Methods: This study is a single blind randomized clinical trial with placebo. A total number of 147 children diagnosed with gastroenteritis induced vomiting and admitted in Amirkabir hospital from August to December 2011 were studied and divided to two case andcontrol groups. In the control group intravenous fluid with distilled water (placebo) was used and the pyridoxine was given along with intravenous fluid therapy in case group. Since admission for three days, numbers of vomiting and other symptoms were collected in data form. Results were analyzed using SPSS-16 by means of descriptive analysis for basic information. Results: Most children were male, aged between 6 months and 2 years and having urban life. There was no significant difference between two groups in the mean of vomiting frequency during the period of hospitalization ( p>0.05 ). T here was also no significant difference between two groups in duration of hospitalization ( p=0.19). Conclusion: Based on this study pyridoxine (Vitamin B6) was not effective in treatment of vomiting due to gastroenteritis in children, and did not reduce the duration of hospitalization.
Reza Karbasi Afshar, Ayat Shahmari, Eiman Lotfian, Amin Saburi,
Volume 13, Issue 4 (1-2013)
Abstract
Introduction : Cardiac events due to coronary artery disease (CAD) are the most common cause of death in all over the world. Myocardial ischemia and its consequent heart failure are considered as common problems and complications of CAD. The purpose of this study was to assess the anti-ischemic effects of fibrates in patients with CAD. Methods : This clinical-trial study was conducted on patients with dyslipidemia and CAD referred to the Baqiyatallah university hospital, Tehran, during 2008-2010. A total of 124 patients randomly divided into two groups: the first group (64 patients) received simvastatin (20-60 mg/day)+fenofibrate (200 mg/day) with lipid-limited diet and exercise and the second group (60 patients) received simvastatin (20-60 mg/day) with diet and exercise for one year and the patients were evaluated at the end of this period. Results : The mean age was 54.3±6.5 years and 53.2% of patients were male. Metabolic equation index was changed from 4.32±0.5 to 5.68±0.5 at the first group (P<0.001) and 4.43±0.9 to 4.41±1.1 at the other one (P=0.121) and also time of exercise was changed from 5.21±1.81 to 6.01±1.8 (P<0.001) and 5.43±1.26±5.23±1.2 (P=0.089) respectively. No serious adverse effects were seen. Conclusion : Lipid-lowering therapy with simvastatin and fenofibrate reduces myocardial ischemia. Therefore it’s recommended to add fenofibrate to statinsin the treatment of dyslipidemia in patients with high risk of cardiovascular accidents as complementary treatment.
Majid Mobasseri, Armin Sadeghi, Alireza Ostadrahimi, Samira Pourmoradian,
Volume 13, Issue 4 (1-2013)
Abstract
Background: Obese patients are at high risk of numerous chronic diseases including diabetes, hypertension, heart disease, dyslipidemia and stroke. Recently researchers focused on complementary medicine along with routine treatments to reduce obesity complications. Therefore we aimed to investigate the effects of omega 3 fatty acids supplementation on serum lipid profiles, C-peptide and fasting blood glucose in obese individuals. Methods: In this randomized clinical trial 56 obese volunteers with the mean age of 33.94±8.15 years were assigned into the supplemented (n=30) and placebo (n=26) groups, given two omega 3 fatty acids soft gel (360 mg EPA and 240 DHA) or placebo respectively for 4 weeks. At the onset and the end of the intervention, blood samples were collected after overnight fasting and serum lipid profiles, C-peptide and fasting blood glucose were measured. Data were analyzed with SPSS program and p-value less than 0.05 considered as significant. Results: In comparison with placebo group, omega 3 supplementation resulted in a significant decrease in the mean triglyceride (108.37±11.22 mg/dl vs 148.84±59.40 mg/dl). After 4 weeks, the mean C-peptide concentrations increased in both groups but elevation in omega 3 group was more dramatic (p<0.01). However, we didn’t find any significant changes in the mean total cholesterol, LDL-C and HDL-C levels. Conclusion: Our finding indicated that 4 weeks Omega 3 supplementation leads to amelioration in some of serum lipid profiles indices and insulin secretion in obese individuals. Although, further studies are needed to achieve precise results.
Abbas Yazdanbod, Afshin Hooshyar, Rasool Nemati, Nasrollah Maleki, Gholamreza Hamidkholgh,
Volume 13, Issue 4 (1-2013)
Abstract
Eosinophilic gastroenteritis is a rare disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal system. The clinical presentation is depending on the involved area and its extension into the layers of the gastrointestinal tract. We repor ted a case of eosinophilic gastroenteritis in the setting of cryptogenic cirrhosis which initially appeared as a tumoral obstruction of the 3rd portion of duodenum which is relieved by surgical bypass and two years later presented as eosinophilic ascitis. The patient was treated with corticosteroid with full absorption of ascitis.
Yousef Shafaiee, Vahid Sadeghifard , Bita Shahbazzadegan ,
Volume 14, Issue 3 (10-2014)
Abstract
Introduction: Complete Amputation of wrist is physical and psychological trauma that can affect person's life. During recent years, various amputated organs were replanted back into their own body leading to improvement in quality of life, function and body image. Case Report : The case was a34 years old man with complete amputation at left hand at wrist level, while working with chainsaw. Patient was admitted to the emergency unit at Fatemi hospital of Ardabil city, and underwent tosurgery for replantation. Conclusion: Complete amputation of wrist and its successful replantation are among rarely occured and reportable cases . The5 -month follow-up indicated a successful operation . During this period, no abnormalities were found in the blood circulation . The finger grasping and nerve development were acceptable and no symptom of infection was observed
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