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Showing 65 results for Ast
Yusef Hamidzadeh Arbabi, Rasoul Nemati, Hamed Rezakhani,
Volume 22, Issue 2 (7-2022)
Abstract
Background & objectives: One of the main effective factors in combating gastric cancer is having good health literacy in the community. The aim of this study was to determine the health literacy of gastric cancer in clients and patients admitted to Imam Khomeini Medical Center in Ardabil.
Methods: The present study was a cross-sectional study. The sample of this study consisted of clients and patients admitted to Imam Khomeini educational -medical center in Ardabil in the second half of 2019. The sample size was 320 people which were randomly sampled. Researcher-made tools were used after ensuring validity and reliability. The questionnaire had two parts: demographic characteristics and items of health literacy dimensions. Patients' informed consent was obtained before completing the questionnaire. Data were collected by nurses and entered into SPSS-26 software. By using descriptive and analytical statistical parameters such as frequency and frequency percentage, mean and standard deviation, t-test and ANOVA analyzed.
Results: The mean and standard deviation of the age of participants was 42.98±14.35. The overall level of health literacy about stomach cancer was calculated as 31.13. The average gastric cancer health literacy in five dimensions in the clients and patients of Imam Khomeini educational-medical center in Ardabil was calculated as follows: access to health information resources was 38.02±10.6, reading health information was 13.47±4.41, understanding health information was 30.37±6.9, evaluation of health information was 16.73±4.58 and decision-making and application of health information was 58.49±10.77. Apart from reading in other dimensions of health literacy, no significant difference was found between clients and inpatients.
Conclusion: The results of this study showed that the mean score of health literacy of clients and patients admitted to Imam Khomeini medical center in Ardabil from gastric cancer is low and not sufficient. Considering the role of health literacy in energy storage, cost and time management of the individual's disease, it is necessary to plan and perform more efficient interventions to promote health literacy in the community, especially clients and patients admitted to Ardabil educational medical centers on gastric cancer.
Soheila Fakhrian Roghani, Allahyar Arabmomeni,
Volume 23, Issue 4 (1-2024)
Abstract
Background: Obesity is a major health problem worldwide. Therefore, the purpose of this study was to determine the effects of l-carnitine supplementation on physical factors related to health and lipid profiles in obese female children with basic gymnastics exercises.
Methods: In this quasi-experimental study, with a pre-test-post-test design and a placebo group, 60 obese children among the girl students of Isfahan with BMI=30.28 kg/m2 were selected purposefully and were divided into 4 groups (Basic gymnastics training, L-carnitine consumption, Combined, and Placebo). The training protocol was implemented for 12 weeks, three times a week, and 45 minutes for each session. Furthermore, the groups of L-carnitine consumption and combined used L-carnitine tablets with a dose of 2 g per day for 12 weeks. To analyze the data, multivariate covariance, and post hoc Tukey tests were used.
Results: A significant increase in Cardio-respiratory endurance, muscular endurance, muscular strength and flexibility was observed in both basic gymnastics training and combined groups (p≤0.001). In addition, a significant decrease in total cholesterol, triglyceride, and LDL and a significant increase in HDL were observed in the basic gymnastics training, and combined groups (p≤0.002). Also, the changes caused by the combined group on all variables were significantly better than other groups.
Conclusions: These findings indicate the beneficial effects of basic gymnastics training along with L-carnitine supplementation on physical factors related to health and lipid profile in obese children. Therefore, the combined use of basic gymnastic exercises and L-carnitine supplementation can be useful to improve these variables.
Homa Akhavan Aghghaleh, Najmeh Ranji, Hadi Habibollahi,
Volume 24, Issue 3 (10-2024)
Abstract
Background: Gastric cancer is a type of malignancy that affects the digestive system. Symptoms of gastric cancer are often hard to detect in the early stages, and become more noticeable only after cancer cells have grown inside the stomach wall and spread to other parts of the body. The genetic code of the cancer cells is located within the genome. Synonymous and non-synonymous mutations are two subgroups of SNP codes. The purpose of this study was to investigate the correlation between genetic variants and susceptibility to gastric cancer in Ardabil province.
Methods: The distribution of variants in the genomic DNA of 150 volunteers from the general population of Ardabil was determined using whole exome sequencing. Databases such as Iranome, Alfa, GnomAD, and 1000G were used to compare allele frequencies. After calculating the frequency of variants using standard methods, Pearson correlation was utilized to statistically analyze their correlation with age-standardized incidence rates (ASRs) for gastric cancer in related populations. A p-value below 0.05 was deemed statistically significant for all analyses. Statistical analysis was conducted using IBM SPSS Statistics version 25.
Results: Significant differences in 19 variants , including rs10061133, rs1050631, rs12220909, rs12983273, rs1695, rs2274223, rs2292832, rs2294008, rs2505901, rs2976391, rs33927012, rs3744037, rs3745469, rs4789936, rs4986790, rs4986791, rs6194, rs63750447, and rs6505162 were found between the general population of Ardabil and other populations. A statistically significant difference was observed and reported at the 0.05 and 0.01 levels in relation to the correlation between the desired variants.
Conclusion: Results suggest a correlation between gene variants in carcinogenesis, highlighting the need for functional studies on gene cooperation in gastric cancer development.
Samira Shahbazzadegan, Mohammad Ali Mohammadi, Iraj Feizi, Faredeh Mostafazadeh, Rana Beheshti,
Volume 24, Issue 4 (1-2025)
Abstract
Background: Fertility is one of the important challenges of women with breast cancer. The incidence of breast cancer among women aged 20 to 49 is gradually increasing, and at the same time, there is evidence that the age of first pregnancy is also increasing, and this requires attention to these issues. Therefore, the present study was conducted with the aim of determining the fertility desire in women with breast cancer in Ardabil in 2024.
Methods: This descriptive study was conducted on women with breast cancer in Ardabil city using a census method. After obtaining the code of ethics and receiving an introduction letter and informed consent from the participants, data were collected using a demographic information questionnaire and a specific fertility desire questionnaire for women with breast cancer. Data analysis was performed using SPSS software using descriptive and analytical statistics.
Results: Data from 180 breast cancer patients were analyzed. The mean fertility desire was 37.86 ± 11.86, which was significantly lower than the criterion value (45) (p<0.001). The mean score of the disease control dimension was 17.81, which was significantly higher than the criterion value (14). The scores of the pregnancy risk, social support, and happiness dimensions were significantly lower than the criterion value (p<0.001). There was a significant relationship between the number of children and the method of adjuvant therapy with fertility desire (p<0.01 and p<0.04, respectively).
Conclusion: Fertility desire in women with breast cancer was low. The reason for the low desire to be fertile was related to the low disease control, social support, and happiness in patients, while it was not related to the risk of the disease. There was a relationship between the desire to be fertile with the treatment method and the number of children and age. The desire to be fertile was higher in women who used chemotherapy alone than in women treated with both chemotherapy and radiotherapy. Also, the desire to be fertile was higher in women with fewer children than in women with more children, and also women with younger age had a higher desire to become pregnant. The study results showed that young women with breast cancer need more attention regarding disease control, social support, and happiness.
Nasim Hajighahramani, Fatemeh Ghasempour,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Breast cancer is a leading cause of cancer-related mortality in women, and finding effective treatments is essential. Among different cancer immunotherapy strategies, vaccines play a prominent role. This study aimed to design a multi-epitope peptide vaccine based on Virus-Like Particles (VLP) against breast cancer using computational methods.
Methods: Antigen sequences of HER2, MUC1, Alpha lactalbumin, Mammaglobin-A and the MS2 adjuvant were retrieved. T-helper (HTL) and cytotoxic T lymphocyte (CTL) inducing epitopes were identified using servers such as IEDB, and their antigenicity and allergenicity were analyzed. Molecular docking was performed using HPEPDOCK between selected epitopes and corresponding MHC molecules. The best selected epitopes and adjuvants were connected by linkers. The designed vaccine’s properties, including allergenicity, antigenicity, solubility, and physicochemical properties were assessed. B-cells and IFN-γ inducing epitopes were identified. Finally, the vaccine’s 3D structure was modeled, refined, and validated.
Results: Epitopes from HER2, MUC1, Alpha lactalbumin, and Mammaglobin-A were identified through immunoinformatics analyses and selection of common HLAs in Iran. The 3D structure of the vaccine was designed, optimized, and validated, showing good stability, solubility, and antigenicity.
Conclusion: This study designed a VLP-based subunit vaccine with adjuvant properties that can enhance antigen presentation and induce robust B and T lymphocyte responses. The vaccine is a promising candidate for preventive or therapeutic use against breast cancer, though experimental and clinical studies are necessary to confirm its efficacy.
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