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Showing 63 results for Sadeghi
Taher Sadeghian, Saeideh Allahyari,
Volume 24, Issue 1 (Spring 2024)
Abstract
Background: Oral mucositis as a complication of chemotherapy has posed significant challenges to the quality of life in cancer patients. Tricyclic antidepressants, including nortriptyline can control the pain caused by mucositis by inhibiting sodium channels. Since patient compliance and rapid drug effect are the goals of the proposed formulation, it was decided to prepare and evaluate a nortriptyline mouthwash according to the United States Pharmacopeia.
Methods: Based on the pharmacopeia, the necessary excipients in the nortriptyline mouthwash were determined, and the amount of each was specified. After validating the UV spectrophotometric technique, drug interaction with the mouthwash container was investigated. In addition to measuring the aqueous activity, necessary microbiological tests were also performed.
Results: The UV spectroscopy method validation for nortriptyline was performed at the obtained maximum absorption wavelength (238.5 nm). The findings of the investigation of the interaction of polyethylene terephthalate container with nortriptyline indicate almost no drug adsorption into the internal part of the mouthwash container over 28 days. The results of antibacterial and antifungal/antimycotic tests were within the standard range of the United States Pharmacopeia. The mouthwash's aqueous activity was also found to be 0.81, indicating an unfavorable environment for microbial growth.
Conclusion: This study has shown that the prepared nortriptyline mouthwash meets microbiological resistance standards and there is no interaction between the active drug ingredient and the proposed container. Therefore, this formulation can be suggested as a promising candidate for clinical exploration.
Roksana Farabi, Aylin Javan-Molaei, Esmaeil Farzaneh, Saeid Sadeghieh Ahari, Sara Mostafalou,
Volume 24, Issue 2 (Summer 2024)
Abstract
Background: Poisoning is one of the common causes of hospital emergency department referrals, especially in adolescents and young people; therefore, knowing the pattern of poisoning will be helpful in identifying risk factors and early detection of poisoning. The aim of this study was to investigate the epidemiology of acute poisoning in adults referred to Imam Khomeini Hospital in Ardabil from 2017 to 2020.
Methods: In this descriptive-analytical and retrospective study, 755 cases related to poisoned patients referred to Imam Khomeini Hospital in Ardabil from 2017 to 2020 were reviewed. The extracted data include ward, gender, age, marital status, place of residence, general status, cause of poisoning, and time of referral, were recorded on the checklist. Obtained Data were analyzed by Chi-square test and SPSS25 software.
Results: The results showed that drug poisoning, opium (opium and its derivatives) and pesticides were the first to third ranks of the most poisoning agents. Most of the poisoned patients were men, married, in the age group of 21 to 30 and living in urban areas. Most of the poisonings were intentional and 33 deaths (4.4%) happened due to poisonings. The cause of poisoning had a significant relationship with age, sex, marital status, place of poisoning (p<0.05) but had no significant relationship with the general condition and time of patients' referral.
Conclusion: Acute poisoning is a major health problem in Ardabil province. The results show that the three agents of drug poisoning, opium and pesticides are the main means of poisoning in adults. Most cases of poisoning occurred in young and adult groups and were in the age range of 21 to 30 years. Poisonings occurred in people aged 31 to 40 were more due to amphetamine. Poisoning with aluminum phosphide tablets had increased compared to before. Consumption of aluminum phosphide is one of the problems of today's societies and it was one of the main causes of death in this research, so it is better to provide necessary measures for management and training for its correct use. Also, by limiting the use of these agents and replacing other methods and techniques, poisoning with these agents can be reduced.
Ali Eskandari, Atabak Sedigh-Namin, Shafagh Aliasgarzadeh, Sara Jalalijivan, Saeid Sadeghieh Ahari,
Volume 24, Issue 4 (Winter 2025)
Abstract
Background: Vasculitis is the inflammation of blood vessel walls, which may lead to vessel damage, narrowing, or occlusion. To better understand the impact of the environment and social factors on the development of vasculitis, more studies need to be conducted in different regions. Early diagnosis based on the prevalence of vasculitis helps in the management and treatment of these patients and prevents irreversible damage, which highlights the importance of diagnosing Vasculitis diseases.
Methods: In this cross-sectional, descriptive study, we evaluated 152 patients who were referred to the Rheumatology Clinic of Imam Khomeini Hospital of Ardabil during the years 2018-2023. The required information was collected by reviewing the patients' medical records in the hospital archive. The relevant information was entered into SPSS software version 22 and evaluated based on the research objectives.
Results: Data from 152 patients were analyzed. Behcet's disease (68.2%) and Wegener's granulomatosis (11.3%) were the most frequent diagnoses. Female patients comprised 53% of the group, with an average age of 36.8 years. Giant cell arteritis patients had the highest average age, while Behcet's patients had the lowest. Most patients resided in Ardabil city and were housekeepers or agricultural workers. Common symptoms included carotid disease and pulse reduction in Takayasu's arteritis, temporal tenderness in giant cell arteritis, weakness and myalgia in polyarteritis nodosa, shortness of breath in Churg-Strauss syndrome, hemoptysis in Wegener's, and mouth sores in Behcet's. ESR and CRP levels were highest in giant cell arteritis compared to other vasculitis types.
Conclusion: Behcet's and Wegener's were the most common vasculitis types. Symptoms varied by disease but often included general signs like fever and myalgia. Elevated ESR and CRP were consistent across cases, with imaging and pathology being key diagnostic tools
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