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Showing 87 results for Mohammadi
Amirsaleh Delara, Rasol Roshan Chesli , Mehriar Nadrmohammadi, Hojjatollah Farahani,
Volume 23, Issue 1 (Spring 2023)
Abstract
Background & objectives: The role of spirituality with its different levels in different countries and societies should be considered for investigating the elderly's health. Therefore, it is necessary to evaluate spirituality with a scale specifically designed to measure spirituality. This study investigated the psychometric properties of the Persian version of the Attitudes Related to Spirituality Scale (ARES) in the elderly.
Methods: In this psychometrics study, the study population included all the elderly of Ardabil city, among whom 459 individuals were randomly selected to fill ARES. The data was analyzed by SPSS and Amos Software.
Results: The reliability of ARES was 0.94 by Cronbach's alpha. Its construct validity, calculated by confirmatory factor analysis, showed that the model for measuring attitudes related to spirituality in the elderly had a suitable fit and its one-factor structure was confirmed (RMSEA=0.001, GFI=0.99, CFI=1).
Conclusion: The Persian version of the Attitudes Related to Spirituality has a one-factor structure, and could be used in psychological studies in Iranian samples due to its acceptable necessary validity and reliability.
Reza Javanshir, Ramin Salimnejad, Mohammad Ghasem Golmohammadi, Hossein Kalarestaghy,
Volume 23, Issue 2 (summer 2023)
Abstract
Premature Ovarian Insufficiency (POI) refers to the loss of ovarian function before the age of 40. This condition can be attributed to various factors including X chromosome abnormalities, autoimmune disorders, and chemotherapy drugs. Hormone therapy is a commonly used treatment for POI, but due to side effects and low fertility rates, alternative treatment options are needed. In recent years, stem cell transplantation has emerged as a promising treatment approach, offering hope for improving and restoring ovarian function. Stem cells possess the unique ability of self-renewal and regeneration, making them potentially effective in addressing ovarian failure and subsequent infertility. Different types of stem cells have been investigated for the treatment of POI, including mesenchymal stem cells (MSCs), stem cells from extraembryonic tissues, induced pluripotent stem cells (iPSCs), and ovarian stem cells. This article aims to provide an overview of the causes and treatment options for Premature Ovarian Insufficiency, with a particular focus on stem cell therapy as suggested by previous studies.
Corresponding Author: Hossein Kalarestaghy, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Email: h.kalarestaghy111@gmail.com
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Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yasin Panahi, Mohammad Ali Shahmohammadi,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Identifying protein interactions is one of the main challenges in the fields of biostructure and molecular biology. Despite extensive progress, the exact patterns of protein-protein interactions are still unknown. The main goal of this study is to computationally evaluate the interactions of fibronectin-1 in the extracellular matrix of decellularized trachea and integrins in adipose tissue stem cells in order to provide the most accurate possible visualization of these interactions and their role in biological processes.
Methods: After decellularization of the sheep trachea through the detergent-enzyme method, histological evaluations and ultrastructure photography of the samples were done by scanning electron microscopy. Also, the simulations of fibronectin1 binding of extracellular matrix protein with integrin αvβ1 and α5β3 of stem cells derived from adipose tissue were investigated, and interaction energy analysis was applied to predict the structure of protein-protein complexes using the algorithms available in HDOCK and ClusPro servers.
Results: The findings indicated the preservation of extracellular matrix components and scaffold ultrastructure. Also, in order to find the most favorable connection states in terms of energy, some of them were reported as stable interactions among the top types of connections. This insight provides a valuable understanding of cell-matrix adhesion, migration, and signaling, with potential implications for therapeutic development.
Conclusion: The prepared scaffolds are ideal for engineering applications for which computational analysis and experimental data have been used for visualization of stable connection states with energy efficiency between fibronectin and integrin. Also, more studies on cell adhesion modeling in connection with tissue engineering science can provide a suitable field for the development of regenerative medicine in further studies.
Yousef Mohammadi-Kebar, Ahad Azami, Aziz Kamran, Erfan Sadeghilar,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Systemic lupus erythematosus is an autoimmune disease in which organs and cells are damaged in the initial stages by tissue-binding autoantibodies and immune complexes. Clinical, demographic and laboratory information of patients with SLE in Ardabil province is the aim of this study.
Methods: The present study is a cross-sectional descriptive study that examines demographic data (age, gender), clinical information such as the first manifestation of the disease, clinical symptoms, etc., and laboratory findings such as CBC, ESR, CRP, proteinuria, FANA, Anti dsDNA, C3, C4, Anti RO and APS Ab of patients who referred to the rheumatology clinic of Imam Khomeini Hospital (RA) in 2021.
Results: Information related to the clinical characteristics of 50 patients, including 46 women (92%) and 4 men (8%), with an average age of 12.14 ± 40.78 years (range: 21-73) and age at diagnosis of 10.62 ± 31.76 years were investigated. The most common initial complaint in the studied patients was related to isolated joint symptoms (28%). The most common clinical symptoms observed in the examined patients were related to joint symptoms along with sensitivity to light with a frequency of 20%. ANA, anti-dsDNA tests positivity and reduced C3 and C4 levels were observed in 88%, 70% and 26% of patients, respectively.
Conclusion: The establishment of a registry system for the structured registration of information of patients with systemic lupus erythematosus in each region is necessary to a better understanding of the characteristics of the disease and better management policy of patients.
Mahzad Yousefian, Ali Mohammadian-Erdi, Afshan Sharghi, Mina Deldadeh Moghaddam,
Volume 24, Issue 2 (Summer 2024)
Abstract
Background: One of the major challenges in surgery is pain control after surgery. The present study was conducted with the aim of investigating the role of magnesium sulfate in improving the quality of anesthesia in patients who are candidates for appendectomy surgery.
Methods: In this clinical trial study, 42 people in the control group and 42 people in the intervention group were randomly included. For the intervention group, 50 mg/kg of magnesium sulfate was injected and for the control group, the same amount of distilled water was injected as a placebo. After surgery, the patients were examined for pain, nausea and vomiting, anxiety, blood pressure and heart rate, and the satisfaction of the surgeon in terms of muscle relaxation. Collected data were analyzed in SPSS-26 by statistical methods and p<0.05 was considered as significant level.
Results: The average pain of the patients in the first, third, sixth and twelfth hours of the study in the intervention group with 1.4, 2.66, 3.3 and 3.19 were significantly lower than the control group. In terms of relaxation, a significant difference was observed between the two groups in the first, third, sixth, twelfth and eighteenth hours of the study. In the examination of nausea and vomiting of patients, no significant difference was observed between the two groups. During surgery, a significant difference was observed in patients receiving magnesium sulfate compared to the control group in terms of surgeon satisfaction.
Conclusion: Magnesium sulfate was effective in controlling patients' pain and anxiety and surgeon's satisfaction during surgery, but it was not effective in controlling patients' nausea and vomiting.
Roya Houshmandi Khaneghahi, Shahram Habibzadeh, Farhad Pourfarzi, Behnam Mohammadi Ghalehbin,
Volume 24, Issue 2 (Summer 2024)
Abstract
Background: Toxoplasmosis is a disease caused by an obligate intracellular protozoan called Toxoplasma gondii. Consumption of raw or undercooked meat infected with tissue cysts and consumption of parasite oocysts are considered the main ways of parasite transmission to humans. The most severe complications of toxoplasmosis occur in people who have an ineffective immune system, as well as during pregnancy. Since the awareness of the prevalence of toxoplasmosis in different population groups and geographical areas and the risk factors involved in it, is one of the most important indicators which can be estimated the risk of infection in any society, this study aims to know the extent of prevalence of anti-toxoplasma antibody in serum and some risk factors related to it in females in Ardabil city.
Methods: Three hundred forty nine female of Ardabil city were randomly selected based on the files available in health centers. This number was divided into ten-year age groups with an age range of 1-69 years. These people were invited and included in the study if they agreed. The designed questionnaire was completed and blood samples were taken. Serum samples were tested using an ELISA kit to detect anti-Toxoplasma IgG antibody.
Results: The prevalence rate of anti-toxoplasma IgG antibody in female residents in Ardabil, aged 1 to 69 years was 45%. The prevalence rate was directly related to increasing age. People’s education level had an inverse relationship with the infection rate. Despite the increase in seropositivity, the prevalence rate in people who had contact with cats was not significant. Also, the prevalence rate had a direct and significant relationship with increasing BMI.
Conclusion: The seroprevalence of anti-toxoplasmosis antibody in female people in Ardabil is equal to 45% and is high compared to the world estimates. 70-75% of people of marriageable age are seronegative and are at risk of contracting acute toxoplasmosis during pregnancy, which requires appropriate preventive health policies.
Samira Shahbazzadegan, Mohammad Ali Mohammadi, Iraj Feizi, Faredeh Mostafazadeh, Rana Beheshti,
Volume 24, Issue 4 (Winter 2025)
Abstract
Background: Fertility is one of the important challenges of women with breast cancer. The incidence of breast cancer among women aged 20 to 49 is gradually increasing, and at the same time, there is evidence that the age of first pregnancy is also increasing, and this requires attention to these issues. Therefore, the present study was conducted with the aim of determining the fertility desire in women with breast cancer in Ardabil in 2024.
Methods: This descriptive study was conducted on women with breast cancer in Ardabil city using a census method. After obtaining the code of ethics and receiving an introduction letter and informed consent from the participants, data were collected using a demographic information questionnaire and a specific fertility desire questionnaire for women with breast cancer. Data analysis was performed using SPSS software using descriptive and analytical statistics.
Results: Data from 180 breast cancer patients were analyzed. The mean fertility desire was 37.86 ± 11.86, which was significantly lower than the criterion value (45) (p<0.001). The mean score of the disease control dimension was 17.81, which was significantly higher than the criterion value (14). The scores of the pregnancy risk, social support, and happiness dimensions were significantly lower than the criterion value (p<0.001). There was a significant relationship between the number of children and the method of adjuvant therapy with fertility desire (p<0.01 and p<0.04, respectively).
Conclusion: Fertility desire in women with breast cancer was low. The reason for the low desire to be fertile was related to the low disease control, social support, and happiness in patients, while it was not related to the risk of the disease. There was a relationship between the desire to be fertile with the treatment method and the number of children and age. The desire to be fertile was higher in women who used chemotherapy alone than in women treated with both chemotherapy and radiotherapy. Also, the desire to be fertile was higher in women with fewer children than in women with more children, and also women with younger age had a higher desire to become pregnant. The study results showed that young women with breast cancer need more attention regarding disease control, social support, and happiness.
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