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Showing 85 results for Mohammadi
Amirsaleh Delara, Rasol Roshan Chesli , Mehriar Nadrmohammadi, Hojjatollah Farahani,
Volume 23, Issue 1 (Spring 2023)
Abstract
Background & objectives: The role of spirituality with its different levels in different countries and societies should be considered for investigating the elderly's health. Therefore, it is necessary to evaluate spirituality with a scale specifically designed to measure spirituality. This study investigated the psychometric properties of the Persian version of the Attitudes Related to Spirituality Scale (ARES) in the elderly.
Methods: In this psychometrics study, the study population included all the elderly of Ardabil city, among whom 459 individuals were randomly selected to fill ARES. The data was analyzed by SPSS and Amos Software.
Results: The reliability of ARES was 0.94 by Cronbach's alpha. Its construct validity, calculated by confirmatory factor analysis, showed that the model for measuring attitudes related to spirituality in the elderly had a suitable fit and its one-factor structure was confirmed (RMSEA=0.001, GFI=0.99, CFI=1).
Conclusion: The Persian version of the Attitudes Related to Spirituality has a one-factor structure, and could be used in psychological studies in Iranian samples due to its acceptable necessary validity and reliability.
Reza Javanshir, Ramin Salimnejad, Mohammad Ghasem Golmohammadi, Hossein Kalarestaghy,
Volume 23, Issue 2 (summer 2023)
Abstract
Premature Ovarian Insufficiency (POI) refers to the loss of ovarian function before the age of 40. This condition can be attributed to various factors including X chromosome abnormalities, autoimmune disorders, and chemotherapy drugs. Hormone therapy is a commonly used treatment for POI, but due to side effects and low fertility rates, alternative treatment options are needed. In recent years, stem cell transplantation has emerged as a promising treatment approach, offering hope for improving and restoring ovarian function. Stem cells possess the unique ability of self-renewal and regeneration, making them potentially effective in addressing ovarian failure and subsequent infertility. Different types of stem cells have been investigated for the treatment of POI, including mesenchymal stem cells (MSCs), stem cells from extraembryonic tissues, induced pluripotent stem cells (iPSCs), and ovarian stem cells. This article aims to provide an overview of the causes and treatment options for Premature Ovarian Insufficiency, with a particular focus on stem cell therapy as suggested by previous studies.
Corresponding Author: Hossein Kalarestaghy, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Email: h.kalarestaghy111@gmail.com
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Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yasin Panahi, Mohammad Ali Shahmohammadi,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Identifying protein interactions is one of the main challenges in the fields of biostructure and molecular biology. Despite extensive progress, the exact patterns of protein-protein interactions are still unknown. The main goal of this study is to computationally evaluate the interactions of fibronectin-1 in the extracellular matrix of decellularized trachea and integrins in adipose tissue stem cells in order to provide the most accurate possible visualization of these interactions and their role in biological processes.
Methods: After decellularization of the sheep trachea through the detergent-enzyme method, histological evaluations and ultrastructure photography of the samples were done by scanning electron microscopy. Also, the simulations of fibronectin1 binding of extracellular matrix protein with integrin αvβ1 and α5β3 of stem cells derived from adipose tissue were investigated, and interaction energy analysis was applied to predict the structure of protein-protein complexes using the algorithms available in HDOCK and ClusPro servers.
Results: The findings indicated the preservation of extracellular matrix components and scaffold ultrastructure. Also, in order to find the most favorable connection states in terms of energy, some of them were reported as stable interactions among the top types of connections. This insight provides a valuable understanding of cell-matrix adhesion, migration, and signaling, with potential implications for therapeutic development.
Conclusion: The prepared scaffolds are ideal for engineering applications for which computational analysis and experimental data have been used for visualization of stable connection states with energy efficiency between fibronectin and integrin. Also, more studies on cell adhesion modeling in connection with tissue engineering science can provide a suitable field for the development of regenerative medicine in further studies.
Yousef Mohammadi-Kebar, Ahad Azami, Aziz Kamran, Erfan Sadeghilar,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Systemic lupus erythematosus is an autoimmune disease in which organs and cells are damaged in the initial stages by tissue-binding autoantibodies and immune complexes. Clinical, demographic and laboratory information of patients with SLE in Ardabil province is the aim of this study.
Methods: The present study is a cross-sectional descriptive study that examines demographic data (age, gender), clinical information such as the first manifestation of the disease, clinical symptoms, etc., and laboratory findings such as CBC, ESR, CRP, proteinuria, FANA, Anti dsDNA, C3, C4, Anti RO and APS Ab of patients who referred to the rheumatology clinic of Imam Khomeini Hospital (RA) in 2021.
Results: Information related to the clinical characteristics of 50 patients, including 46 women (92%) and 4 men (8%), with an average age of 12.14 ± 40.78 years (range: 21-73) and age at diagnosis of 10.62 ± 31.76 years were investigated. The most common initial complaint in the studied patients was related to isolated joint symptoms (28%). The most common clinical symptoms observed in the examined patients were related to joint symptoms along with sensitivity to light with a frequency of 20%. ANA, anti-dsDNA tests positivity and reduced C3 and C4 levels were observed in 88%, 70% and 26% of patients, respectively.
Conclusion: The establishment of a registry system for the structured registration of information of patients with systemic lupus erythematosus in each region is necessary to a better understanding of the characteristics of the disease and better management policy of patients.
Mahzad Yousefian, Ali Mohammadian-Erdi, Afshan Sharghi, Mina Deldadeh Moghaddam,
Volume 24, Issue 2 (Summer 2024)
Abstract
Background: One of the major challenges in surgery is pain control after surgery. The present study was conducted with the aim of investigating the role of magnesium sulfate in improving the quality of anesthesia in patients who are candidates for appendectomy surgery.
Methods: In this clinical trial study, 42 people in the control group and 42 people in the intervention group were randomly included. For the intervention group, 50 mg/kg of magnesium sulfate was injected and for the control group, the same amount of distilled water was injected as a placebo. After surgery, the patients were examined for pain, nausea and vomiting, anxiety, blood pressure and heart rate, and the satisfaction of the surgeon in terms of muscle relaxation. Collected data were analyzed in SPSS-26 by statistical methods and p<0.05 was considered as significant level.
Results: The average pain of the patients in the first, third, sixth and twelfth hours of the study in the intervention group with 1.4, 2.66, 3.3 and 3.19 were significantly lower than the control group. In terms of relaxation, a significant difference was observed between the two groups in the first, third, sixth, twelfth and eighteenth hours of the study. In the examination of nausea and vomiting of patients, no significant difference was observed between the two groups. During surgery, a significant difference was observed in patients receiving magnesium sulfate compared to the control group in terms of surgeon satisfaction.
Conclusion: Magnesium sulfate was effective in controlling patients' pain and anxiety and surgeon's satisfaction during surgery, but it was not effective in controlling patients' nausea and vomiting.
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