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Showing 6 results for Zandi
Seyedreza Borzou, Mahmood Golyaf, Roya Amini, Mitra Zandiha, Bita Torckman,
Volume 8, Issue 3 (Autumn 2008)
Abstract
Background & Objectives: hyperphosphatemia and hyperkalemia have major roles of mortality and morbidity in hemodialysis patients. In this study we evaluated the effectiveness of increase in blood flow rate on blood potassium and phosphate of hemodialysis patients.
Methods: This is a clinical trial study 42 patients were assessed during the hemodialysis. A questionnaire and laboratory tests were used for gathering data. At first questionnaire of demographic data was completed and then the weight of patients was connected to each session of dialysis. Then the patient was connected to dialysis machine and blood sample was gathered before dialyzer. After taking blood sample, flow rate was regulated on 200 ml/min in the first session and on 250 ml/min in the next session. During hemodialysis, hemodynamic status and clinical status of patients was controlled. At the end of hemodialysis and before disconnection patient from dialysis machine, a blood sample was taken from arterial set before dialyzer (4 blood samples for each patient). Blood sample was sent to laboratory and all of them were analyzed by one technician and with one set.
Results: Average phosphorus changed significantly from 3.35 to 2.94 with increasing Qb from 200 to 250 similar to the increase in Qb in potassium removal (from 3.43 to 3.52) meq/lit. Paired t-test (p0.005).
Conclusion: It can be concluded so that increase in blood flow rate from 200ml/min to 250ml/min, can affect removal phosphorus but can not affect removal of potassium
Sayeneh Khodadadi, Ashraf Mohabati Mobarez, Naser Harzandi , Bahman Tabaraei , Nima Khoramabadi, Amir Bakhtiyari , Hanyieh Aghababa ,
Volume 12, Issue 1 (spring 2012)
Abstract
Background & Objectives: The identification of Brucella spp. antigens with the capacity to elicit a protective immune response is of the great interest for the researchers. So, characterization and assessment of diverse antigens of Brucella need to be evaluated. In this study, we report the cloning and expression of the gene coding for 31 KDa OMP (OMP31) of Brucella melitensis 16M. Methods: Brucella melitensis Omp31 gene was amplified with specific primers, cloned into pJET1/2 and subsequently subcloned in pET28a (+) vector. Both these recombinant plasmids were sequenced and then after, expression of recombinant protein was induced by 1mM IPTG. Western blot analysis was also performed by polyclonal rabbit antiserum. Results: Omp31 successfully was cloned in both plasmid vectors. The recombinant Omp31 was expressed in E.coli host and purified with significant yield. Western blot results along with those of sequencing ensured accurate production of recombinant omp31 and retaining of its partial epitopes. Conclusion: Our results show that, an expression host such as E. coli is suitable for omp31 production.
Fereshteh Sharifi Ferdoey , Shiva Irani, Mojghan Zandi, Masoud Soleimani,
Volume 14, Issue 3 (Autumn 2014)
Abstract
Background & objectives : T he main goal of tissue engineering is regeneration and restoration of damaged tissues and organs, besides being used in medicine . Scaffolds are the main segments for tissue engineering, and plasma surface modification is one of the modern methods used for surface modification on polymer scaffolds. The aim of this study was to evaluate the effect of nano-fibers with different densities on fibroblasts' behavior besides the plasma surface modification. Methods : Poly Ɛ-Caprolactone nano-fibers (PCL) were developed by an electro-spinning technique at different collecting times. These nano-fibers were then modified by oxygen plasma. Cellular attachment to the nano-fiber and their morphology were evaluated using scanning electron microscope (SEM) and cellular activities were also studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5 diphenyltetrazolium bromide (MTT). Scaffold biocompatibility test was assessed using inverted microscope. Results : Scanning electron microscope images of nano-fibers showed that increase in time of spinning has significantly heighten fiber density, on the other hand plasma surface modification of nano-fibers had significant effects on their respective biocompatibilities. The result of cell culture showed that nano-fiber could support the cellular growth and replication by developing 3-dimensional topography. Conclusion : Our results showed that increase in time of spinning and using plasma surface modification of nano-fibers by oxygen plasma would result in providing surface with the highest similarity to the extracellular matrix.
Amirahmad Arabzadeh , Hamed Zandian , Iraj Poorfarzan, Reza Alaei , Negin Haghshenas , Saeid Sadeghiye Ahari , Mirsalim Seyedsadeghi,
Volume 18, Issue 2 (summer 2018)
Abstract
Background & objectives: Trauma is one of the most common causes of death in the age range 1 to 44 and the third cause of death regardless of age. Abdominal trauma is one of the most common types of trauma. This study aimed to investigate the frequency of causes of laparotomy in penetrating and blunt abdominal traumas in 2016.
Methods: This descriptive study was conducted on 120 medical records of patients hospitalized for penetrating and blunt abdominal traumas in Fatemi Hospital, Ardabil, 2016. The inclusion criterion consisted of all patients undergoing laparotomy due to abdominal trauma. In this study, age, gender, education level, type of trauma (blunt or penetrating), results of laparotomy surgery, physical examination and paraclinical findings of patients before operation were collected by a researcher- made checklist.
Results: The results showed that 80% of the patients were male and 35% were in the age range 20-29years. Of patients, 38.3% had penetrating trauma and 61.7% blunt trauma. The most common mechanism of blunt abdominal trauma was car accident (83.8%). Penetrating object was the cause of all penetrating abdominal traumas. Peritoneal stimulation symptoms were observed in 56.5% of penetrating abdominal traumas and 62.2% of blunt abdominal traumas. Hypotension was observed in 21.7% of patients with penetrating abdominal trauma compared with 62.2% in patients with blunt abdominal trauma. The most prevalent damaged organ in patients with blunt trauma was spleen (51.4%). The most prevalent damaged intraabdominal organ was small bowel (17.4%). Negative laparotomy was significantly higher in patients with penetrating trauma than those with blunt trauma (p<0.0001). Moreover, 9.2% of all patients had died and mortality rate was higher in patients with blunt trauma than penetrating trauma (p<0.05) .
Conclusion: The results of this study showed that: 1. Road traffic accident and penetrating object were the most common causes of laparotomy in patients with blunt and penetrating trauma respectively; 2. Spleen and small bowel were the most prevalent damaged organs in blunt and penetrating abdominal trauma respectively and; 3. Young males were at highest risk of abdominal traumas.
Zahra Ashouri Saheli, Mohammad Shenagari , Naser Harzandi , Ali Monfared,
Volume 19, Issue 2 (summer 2019)
Abstract
Background & objectives: Immunosuppressive drugs that are used for decreasing risk of acute rejection and renal graft loss can lead to reactivation of latent viruses for example BKV and JCV in either renal allograft or recipients. These viruses can lead to renal graft loss. The purpose of this study was to evaluate the quality and quantity of the genome of these two viruses in the renal recipients’ plasmas for early detection.
Methods: In this retrospective descriptive study, at first, DNA extraction test was performed on 102 plasma samples of renal allograft recipients. And then, BKV and JCV DNAs were detected and quantified by Real-Time PCR.
Results: Fifty four (52.94%) BKV DNA positive and 26 (25.50%) JCV DNA positive were found in 102 recipient plasma samples. Linear range of measurements for BKV and JCV DNAs were within the range of 10 7-0.596 copies/ µl and 10 7-0.528 copies/ µl respectively. After calculation of genes amounts based on copy/ml in the plasmas, numbers and percent of positive cases were highlighted in the four categories. BKV and JCV DNA (Co-infection) were detected in 22 (21.56%) plasma samples.
Conclusion: Real-time PCR is a quantitative and qualitative PCR method that can detect genome of any type of organisms and their amounts (even in trace amounts), so using of this method is very important for early detection of viruses which can cause diseases and graft rejection in renal transplant recipients.
Davood Salati Momeni, Hamed Zandian, Habib Ebrahimpour, Vali Nemati,
Volume 21, Issue 2 (summer 2021)
Abstract
Background & objectives: The main motivator of hospitals is manpower. The expansion and complexity of educational medical centers and the appearance of new diseases such as Covid-19 have increased the need for effective management. During the Covid-19 crisis, in which hospitals are at the forefront, special measures should be taken for better management in critical situations. The current study has been conducted with the aim of identifying the main factors affecting management in crisis and its control.
Methods: The study method was the "Mix Method" performed in two stages. The first stage was exploratory; in this stage 19 university experts as a research sample were selected by simple random sampling. The second stage was a quantitative, confirmative, and survey study. 202 patients were selected randomly as a research sample from both educational-medical centers involved in Covid-19 of Ardabil city. Data were collected by using a questionnaire. Descriptive analysis of data was performed using SPSS software for heuristic factor analysis, and LISREL software was also used for confirmatory factor analysis and finding correlations between factors.
Results: In this study, 17 factors were identified and confirmed, affecting the crisis management in 5 dimensions, including; safety training, crisis control, trust in human resources, sense of vulnerability, the physical and mental health, transparency, justice, participation in decision-making, trust in the manager, honesty, the expectation of needs, efficiency, reward, elimination of stresses, fulfillment of manager's promises, controlling of crisis, inter-sectorial solidity. There was a significant correlation between factors with latent variables.
Conclusion: From the perspective of management, being prepared and training the committed forces are very important in controlling the crisis. Manpower plays the main role in the Covid-19 crisis and treating patients, so paying attention to them by considering the factors and dimensions of leadership, social, motivation, organization, and quickness has high importance.
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