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Showing 12 results for Yazdanbod
Manoochehr Iranparvar, Abbas Yazdanbod , Firooz Amani, Shabnam Sohrabi ,
Volume 3, Issue 3 (Autumn 2003)
Abstract
Background & Objective : Palpable thyroid nodules are found in almost 5% of the adults. Regarding the high prevalence of this condition, recognizing and evaluating them are important for physicians. Fine Needle Aspiration (FNA) is the first easy and cost-effective way for recognizing pathologic nature of the nods. The present research was an attempt to investigate the epidemiology and evaluate the pathological findings among patients using FNA. Methods : This is a descriptive study conducted on all 145(113 female and 32 male) patients referring to the endocrinology clinic of Ardabil in the period between October 1999 to October 2002. The data were collected using a questionnaire, the physical examination of the patients, noting down the clinical finding, doing FNA and its report presented by a pathologist. The data were then analyzed with descriptive statistics and frequency tables using SPSS software. Results : Most of the patients (36.5%) were 30-40 years old. FNA of 115 patients (79.4%) was reported as benign and that of 6 patients (4.1%) was malignant, 16 patients (11%) had a doubtful FNA, and in 8 patients (5.5%) the sample was not enough. Among patients with benign FNA, 102 cases (70.6%) had nodular goiter, 8 cases (5.5%) had colloid cyst, 3 cases (2%) had follicular adenoma and 2 cases (1.3%) had thyroiditis. Among patients with malignant FNA 1 case (0.7%) had follicular carcinoma and 5 cases (3.4%) had papillary carcinoma. Conclusions : The results indicated that most of the malignant lesion is papillary carcinoma, which has a lower prevalence compared to similar studies. Regarding the higher prevalence of thyroid carcinoma in middle ages it seems necessary to investigate the thyroid nodules in this age- group.
Abbas Yazdanbod , Manoochehr Iranparvar, Solmaz Seifi ,
Volume 4, Issue 3 (Autumn 2004)
Abstract
Background &Objectives: According to a recent report published by the Ministry of Health in Iran gastric cancer is the most common cause of death due to cancer in this country and cardiac cancer is the most common kind of upper GI cancer. This study is an attempt to determine the epidemiology of cardiac cancers in Ardabil. Methods: This descriptive cross-sectional study was conducted for four years (2000-2003) at the only private clinic in Ardabil. The results of endoscopy of these patients including the exact determination of the topography of cancer in cardia and other general information were recorded. The data were analyzed using SPSS software (version-10) Results: During this study 4356 endoscopy were done and 533 histologically proven upper GI cancer were detected. Out of 533, 242 cases were located at E-G junction area, 82(33.9%), 130 (53.7%) in cardia region and 30(12/4%) cases were located at the proximal bady of stomach. 130(53.7%) cases of tumors were, in the right side of cardia. Bormann classification showed that most of cancers (43.8%) were ulceroinfiltrative. Conclusion: Statistical analysis indicated that there is a significant relationship between type and topography of cancer with dysphasia, weight loss and epigasteric pain(p<0.05). The results showed significiant relationship between type and topography of cacers with Bormann classification(p=0.001). Further epidemiologic studies are required to evaluate etiology of cardia cancers in Ardabil.
Eabbas Yazdanbod, Fateme Samadi, Reza Malekzade, Masuood Babaie , Manoogehr Iranparvar , Ahmad Azami ,
Volume 5, Issue 2 (Summer 2005)
Abstract
Background & Objectives: Recent studies in Ardabil province indicated that upper GI cancer is the most common kind of cancer in this province. Due to the lack of any study concerning the survival rate of the patients in this province, the present research set out to evaluate the effect of demographic features of GI cancers, risk factors, histopathology type, the site of tumor and treatment on the survival rate of these patients. Methods: In this descriptive-analytical and prospective study, we followed up 420 upper GI cancer cases (141 esophagus cancers and 279 stomach cancers) who were initially diagnosed in the only subspeciality GI clinic of Ardabil province during four years from 2000 to 2003. Results: The information related to 299 patients was recorded. The dates of death of 55 cases were found referring to the provincial death registration program while the addreses of 67 cases were not found. The 1-4-year survival rates in the patients with upper GI cancer in Ardabil province were 25.9%, 11.1%, 4.5% and 1.8% respectively. In this study men had a lower survival rate than women and patients with esophagus cancer had a longer survival rate. In the patients with stomach cancer "Signet ring cell type" histopathology had the lowest survival rate. The patients who had undergone surgery survived longer than other patients with no resectional surgery treatment. Histopathology grading, age at first diagnosis, positive familial history of GI cancer, as well as cigarette, alcohol and opium consumption had no effect on survival rate of these patients. Conclusion: Overall survival rate of our patients is very low this condition might be related to late diagnosis and less treatment facilities in Ardabil province.
Ahad Azami , Abbas Yazdanbod, Nateg Abbasgolizadeh, Yegane Sadeghy,
Volume 6, Issue 2 (Summer 2006)
Abstract
Background & Objectives: According to a recent report published by the ministry of health, Esophageal cancer is the second most common fatal cancer in Ardabil. This study investigated the relationship between anatomical sites and pathological features of Esophagus cancer with related risk factors. Methods: This descriptive-cross-secional and prospective study was conducted on patients referring to GI clinic of Ardabil (Aras) between 2000-2003. Patients with suspicious upper GI symptoms underwent upper GI vide-endoscopy. At least five to six endoscopic punch biopsies were obtained from all the lesions and sent for pathology. Diagnosis was confirmed by pathology. Anatomical sites, demographic information of the patients (age, sex, educational state, residential area) smoking habit, alcohol and opium consumption were entered into the questionnaire. Statistical analyses were performed using the EPI 2000 statistical software. Results: The mean age of the patients with cancer was 59 ± 11.64 years and the male to female ratio was 1:1. Villagers constituted 117 (77%) of the patients. 93.4% of these patients were illiterate. The cancers were of the following types: 126 (82.9%) SCC, 25 (16.4%) adenocarcinoma and 1(0.7%) in situ carcinoma. The most common site of esophageal SCC cancer was middle third of esophagus with 73 (48%) patients. In contrast the most common site of adenocarcinoma in 31 (20%) patients was lower third of esophagus. No meaningful relationship was found between esophageal cancer and smoking drinking or opium consumption. Conclusion: The findings indicated that unlikewestern countries esophagus cancer had no relationship with smoking or alcohol consumption in Ardabil. Other studies are recommended to be performed to find out more about relationship between known esophageal risk factors including nutritional habits, nitrosamines, soil contents, agricultural products and genetic background.
Farhad Salehzadeh , Dina Emami , Aliasghar Zolfeghari , Abbas Yazdanbod , Shahram Habibzadeh , Bahman Bashardoost , Manoochehr Barak , Eiraj Feizy , Hormoz Azimi , Marina Jastan , Jafar Khalafi ,
Volume 6, Issue 3 (Autumn 2006)
Abstract
Background and Objectives: Familial Mediterranean fever which is the prototype of the hereditary periodic fever syndromes is common in the countries around the Mediterranean Sea. Regarding the geographical position of the northwest of Iran, having Turkish originality and its vicinity to the Mediterranean Sea , the incidence of this disease is significant in Ardabil. The goal of this study was to introduce Familial Mediterranean Fever as a disease with significant outbreak in this area. Methods: This research is a descriptive study which has been done during one year from October 2004 to October 2005. According to the Tel-Hashomer criteria, the patients suffering from Familial Mediterranean Fever were collected from private clinics and pediatric rheumatology clinics records. Then from 112 patients only 74 ones were studied. All of the patients were interviewed and filled out a questionnaire. Results: Familial Mediterranean fever is common among children under 18 (76%) and more common in male than female. Abdominal pain has been the most common complaint (74%) and abdominal pain and fever (95% and 84% respectively) were the main clinical symptoms. The most common period of pain was 12-72 hours and the common recovery (attack free) period was from 1 week to 1 month (63/5%). Majority of the patients had hospital admission for diagnostic work up (85%) and some of them (32%) had been under surgical operation mistakenly. On the whole 92% of the patients had taken medications as a result of wrong diagnosis and 20% had positive familial history. 50% of the patients' parents were first degree relatives and in 59.5% delay in diagnosis was more than 3 years. Conclusion: Results of this study and introduction of this group of patients in a one-year research indicate that: Familial Mediterranean Fever is more common in the Northwest of Iran although physicians are not familiar with that. The common age for manifestation of this disease is under 18 and its presentation after the age of 40 is very rare.
Abbas Yazdanbod , Manoochehr Iran Parvar , Firooz Amani , Reza Malekzadeh , Saeid Salavati ,
Volume 6, Issue 3 (Autumn 2006)
Abstract
Background and Objectives: Gastric cancer is the second most common cause of cancer in terms of mortality in the world. Ardabil province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) Adeno carcinoma in Iran. The most common site of upper gastrointestinal cancer in Ardabil is cardia region (its right-side wall). Therefore this study aimed to investigate comparatively histopathology of right and left side of cardia and z-line considering the incidence of inflammatory and precancerous lesions. Methods: This descriptive and cross-sectional study was performed on one hundred adults who referred to Aras clinic for endoscopy. Endoscopy was done with video endoscope and a single biopsy was taken from right and left side of cardia and z-line respectively and one from antrum for H.Pylori. All the samples of the biopsy material were fixed in formalin in separate bottles and pathologic study of the samples with regard to inflammatory and precancerous lesions were done according to Sydney classification of gastritis. The collected data wereanalyzed by SPSS software using descriptive and analytical statistics. Results: 61 (61%) patients were male and 39 (39%) female. The age range of patients was 19-80 years old (standard deviation 53±16.2). Mild to severe inflammation in left and right side of cardia and z-line was 82.6%, 84%, 97.1%, 93%, mild to severe atrophy in 22.8%, 28.7%, 26.5%, 24.4% and metaplasia type 1 to 3 in 2.2%, 6.4%, 2.9%, 12.2% respectively. Suspected dysplasia in cardia and z-line was only in one case. Analysis of these variables with McNamara, Wilcoxon and Lambda tests showed no statistically meaningful difference considering the histopathological findings in left and right side wall of cardia and z-line Conclusion: This study showed no statistically meaningful difference between right and left wall of cardia and z-line considering the incidence of inflammatory and precancerous lesions. This observation is not consistent with high incidence of right sided cardia cancer. Further study with multiple biopsy sample and more sensitive methods is recommended for the diagnosis of precancerous lesions.
Farhad Pourfarzi , Afsaneh Enteshari Mogaddam, Abbas Yazdanbod , Zahra Tazakkori , Esmaeil Farzaneh , Mehrdad Mirzarahimi,
Volume 11, Issue 1 (spring 2011)
Abstract
Background & Objectives : Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is common through the world including Iran. Because of its chronic nature and lack of effective treatment, patients are always anxious and stressful and physicians are also exhausted of untreated patients. The cause of IBS is unclear and it has not effective treatment. Therefore, there is a need to find and introduce a proper method of treatment to control symptoms including abdominal pain and defecation changes. This study was aimed to determine the effectiveness of probiotic yogurt on the general relief of symptoms associated with IBS. Methods : Subjects were recruited from patients of gastroenterology clinic in Imam Khomeini Hospital, Ardabil. A total of sixty patients fulfilling the Rome II criteria took part in this study. Subjects were randomized into two groups of trial and control. Pre- and post- treatment symptoms were investigated using a questionnaire. Thirty one patients received probiotic and 29 patients normal yogurt for 4 weeks. Bottles of yoghurt were manufactured, and coded by a company. Both participants and researcher were blinded for the bottles' code. The symptoms were followed before and after two and four weeks of treatment and two weeks post- discontinuing of trial, too. Data were analyzed by SPSS (Ver. 17) and differences between groups were compared statistically using of chi-square and t-test. Results: A total number of 60 patients were recruited in this study of whom 36 (60%) were female and 24(40%) male. The average age of participants was 34.1±9 which did not differ between two groups. The onset of symptoms did not show any difference between two groups. The trial group had a history of 5.7±5.1 years while this was 6.5±4.9 for the controls. In overall, patients who were given probiotic yogurt had shown a better response in the control of abdominal pain and flatulence than those who were treated with normal yogurt. There was not a significant difference between two groups in the response to treat for other symptoms including epigastric pain, vomiting, frequency of defecation and feces consistency. Conclusion: According to our research, adding probiotic yogurt to the patient diet may help ease symptoms of IBS especially, abdominal pain and flatulence. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms can have positive public health consequences.
Farhad Pourfarzi, Abbas Yazdanbod, Reza Daneshvar , Seiyed Hosein Saberi ,
Volume 12, Issue 5 (suppl 2012)
Abstract
Background & Objectives: Colorectal cancer is considered as the third prevalent malignancy worldwide. Investigation of information on cancers in Iran during 1985-1996 showed an increase in the incidence and prevalence of colorectal cancer. Its rank in Iran has increased from 9 to 5th during 10 years. It was reported as high prevalent cancer in Iranian people aged less than 40 years among Asian countries. Methods: In this cases-control study patients with a pathologic report of colorectal cancer were recruited among those cases registered in Ardabil Cancer Registry. Control group were selected from neighbors, frequency matched for age and gender. Subjects were interviewed using a questionnaire consisting information on age, gender, smoking, drugs and alcohol consuming, diet, family history of cancer and serum IgM and IgG level for H. pylori. Data were analyzed using SPSS v16. Results: In the current study, 43 persons (53.8%) were male and 37 (46.2%) were female. In the case group, 10 persons (12.5%) were under 40, 34 cases (42.5%) in age group of 41- 60 and 36 persons (45%) were more than 61 years. In the control group 12 persons (15%) were under 40, 36 persons (45.5%) in age group of 41-60 and 40 persons (68%) were more than 61 years. In the control group 3 cases had BMI less than 19, 36 cases (45%) between 19-24.9, 31 cases (38.8%) between 25-29.9 and 10 cases (12.5%) were more than 30, whereas this variable was 2.5, 32.5, 46.2 and 18.8% respectively in the case group. Positive history of smoking found to increase the risk of cancer around 1.8 times (OR= 1.78 CI: 0.91- 5.85). However, significant difference was not observed between two groups regarding alcoholic beverage consumption (p=0.385) . There were significant differences between two groups in terms of vegetables and carbohydrates intake. Difference was also significant between two groups regarding positive level of IgG. Among studied persons, 19 and 13 patients in case and control group had positive IgM respectively. Conclusion: Our finding showed an increased risk colorectal cancer in those consuming low vegetable and fruits and high carbohydrate consuming, having smoking history, positive family history of cancer and serum IgG level.
Abbas Yazdanbod, Afshin Hooshyar, Rasool Nemati, Nasrollah Maleki, Gholamreza Hamidkholgh,
Volume 13, Issue 4 (Winter 2013)
Abstract
Eosinophilic gastroenteritis is a rare disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal system. The clinical presentation is depending on the involved area and its extension into the layers of the gastrointestinal tract. We repor ted a case of eosinophilic gastroenteritis in the setting of cryptogenic cirrhosis which initially appeared as a tumoral obstruction of the 3rd portion of duodenum which is relieved by surgical bypass and two years later presented as eosinophilic ascitis. The patient was treated with corticosteroid with full absorption of ascitis.
S Bakhti, S Latifi-Navid, S Zahri, A Yazdanbod,
Volume 15, Issue 3 (autumn 2015)
Abstract
Background & objectives: Several studies have described VacA and CagA as the two important virulence determinants of Helicobacter pylori, which are associated with gastric ulcer (GU) and duodenal ulcer (DU). The aim of present study was to determine the associations of the i and d regions genotypes of H. pylori vacA gene and cagA status with GU and DU risk.
Methods: A total of 177 isolates were cultured from the biopsies of Iranian patients with different geographic origins and genotyped. Data were collected and analyzed.
Results: Frequency of the vacA i1, i2, i1i2, d1, and d2 alleles and cagA in all patients was 42.9%, 55.4%, 1.7%, 41.8%, 58.2% and 68.4%, respectively. There was a significant difference between the frequencies of vacA i1 in isolates from GU than those from non-atrophic gastritis (p<0.05). When the GU was considered as a dependant factor by the multiple logistic regression analysis, the vacA i1 genotype was significantly associated with the age- and sex-adjusted risk for GU (p=0.006, odds ratio [OR]=3.56 95% confidence interval [CI]=1.45–8.75). Statistical analysis showed no significant association between vacA d genotype and digestive diseases. After controlling for age and sex variables, the cagA genotype remained in the final model when the DU was considered as a dependant factor by the the multiple logistic regression analysis (p=0.021, OR=3.77 95% CI=1.22-11.60).
Conclusion: We have proposed that the H. pylori vacA i1 and cagA genotypes could be considered as benefit biomarkers for prediction of risk of GU and DU in Iran, respectively.
Effat Seyedhashemi, Elham Niasti, Nima Farahmand, Mohammad Mazani, Abbas Yazdanbod, Firouz Amani, , Seyyed Saeid Hossini-Asl ,
Volume 19, Issue 4 (winter 2019)
Abstract
Background & objectives: Gastric cancer has a very wide geographic distribution. Identification of the genetic factors involved in the cancer predisposition is very important. IL-1β as a pro inflammatory cytokine is involved in gastric acid secretion in the H. pylori infected individuals. This study was aimed to evaluate the role of IL-1β-511 polymorphism on the susceptibility to gastric cancer in residents of Ardabil province.
Methods: One-hundred patients affected with gastric cancer and 100 normal individuals were selected as case and control groups, respectively. After DNA extraction from peripheral blood samples, the presence of the polymorphism IL-1β-511 was determined via PCR-RFLP assay. The results were evaluated by agarose gel electrophoresis.
Results: Among cases, CC, CT, and TT genotypes were observed in 19%, 60%, and 21% of individuals, respectively. Also, the distribution of genotypes among the participated individuals in control group was 4%, 67%, and 29%, respectively. There was a significant difference (p<0.05) between case and control groups.
Conclusion: According to this study, there was a significant relationship between IL-1β 511C allele polymorphism and gastric cancer in patients with gastric cancer in Ardabil province. It is indicated that some of the polymorphisms in IL-1β cytokine are associated with gastric cancer, and this finding would be used as a predictive value.
Mehdi Valizadeh , Esmaeil Babaei, Rasoul Sharifi, Abbas Yazdanbod,
Volume 20, Issue 2 (summer 2020)
Abstract
Background & objectives: Colon cancer is a common disease in the world that causes high mortality in affected people. The lack of appropriate diagnostic and prognostic markers has led to the failure in early diagnosis of colorectal malignancies. MicroRNAs play an important role in controlling the expression of target genes involved in the development and progression of colon cancer. The aim of the present study was the bioinformatics identification of microRNAs with distinct expression in cancerous and non-cancerous colon samples.
Methods: This type of study was theoretical bioinformatics and microarray data of 1513 colon cancer samples with the accession number of GSE115513 were obtained from the GEO site and marker genes were selected by using R program. Target genes of the identified microRNAs were provided by TARGETSCAN software and finally, the graphical network was plotted in Cytoscape software.
Results: Analysis of microarray data showed that has-miR-663b, has-miR-650, has-miR-17-5p, has-miR-4539 and has-miR-501-3p have biomarker potential in cancer samples. Statistical analysis and investigation of the target genes indicated that miR-663b (ROCAUC=0.8965, p=0.001) and has-miR-650 (ROCAUC=0.9104, p=0.001) had significant distinct expression between cancerous and non-tumor margins with biomarker potential.
Conclusion: The has-miR-663b and has-miR-650 genes can be used as diagnostic markers to distinguish colon cancer from non-cancerous samples
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