Introduction : Cardiac events due to coronary artery disease (CAD) are the most common cause of death in all over the world. Myocardial ischemia and its consequent heart failure are considered as common problems and complications of CAD. The purpose of this study was to assess the anti-ischemic effects of fibrates in patients with CAD.

  Methods : This clinical-trial study was conducted on patients with dyslipidemia and CAD referred to the Baqiyatallah university hospital, Tehran, during 2008-2010. A total of 124 patients randomly divided into two groups: the first group (64 patients) received simvastatin (20-60 mg/day)+fenofibrate (200 mg/day) with lipid-limited diet and exercise and the second group (60 patients) received simvastatin (20-60 mg/day) with diet and exercise for one year and the patients were evaluated at the end of this period.

  Results : The mean age was 54.3±6.5 years and 53.2% of patients were male. Metabolic equation index was changed from 4.32±0.5 to 5.68±0.5 at the first group (P<0.001) and 4.43±0.9 to 4.41±1.1 at the other one (P=0.121) and also time of exercise was changed from 5.21±1.81 to 6.01±1.8 (P<0.001) and 5.43±1.26±5.23±1.2 (P=0.089) respectively. No serious adverse effects were seen.

  Conclusion : Lipid-lowering therapy with simvastatin and fenofibrate reduces myocardial ischemia. Therefore it’s recommended to add fenofibrate to statinsin the treatment of dyslipidemia in patients with high risk of cardiovascular accidents as complementary treatment.

Background & objectives: Most of coronary angiography patients have not enough information about undergoing procedure . This lack of knowledge makes anxiety in patients and thereby changes their vital signs. There is no study regarding the effective education of patients based on their native language. This study was done to investigate the effect of video education in native language on vital signs caused by anxiety of patients undergoing coronary angiography.

Methods: This quasi experimental study was done in 2013 on 160 patients undergoing angiography in Imam Khomeini Hospital in Ardabil. Participants were divided into two groups randomly (80 in each group): case (native video education) and control groups. The sheets of hemodynamic variables were completed in determined time intervals for data collection. ANOVA with repeated measures and Chi square were used to analyze the data in SPSS13 software. P-value<0.05 was considered statistically significant.

Results: The results of repeated measures ANOVA showed significant improvement in vital sign variables except for temperature in both groups over the time (p<0.05). And there was significant difference in the mean vital sign variables in determined time intervals (p<0.05).

Conclusion: Video education in native language decreases the vital signs in coronary angiography patients. Therefore the video education especially in native language is recommended for improving vital signs before invasive procedures.