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Showing 6 results for Shahla
Homayoun Sadegi Bazargani , Shahnam Arshi, Ali Akbar Mortazazadeh, Jafar Bashiri , Naiere Aminisani, Saied Hashem Sezavar , Hasan Adalatkhah , Shahram Seifnejad, Ali Ruhi, Hale Shahlazadeh ,
Volume 5, Issue 2 (Summer 2005)
Abstract
Background & Objectives : Providing health services for all population subgroups of a community is a major hallmark for health administration. Little is known about health status of Ashayer population in Iran. This study aims at evaluating health status and quality of health service delivery to them. Methods: In a cross-sectional research 320 households (1800 persons), entered the study. Moreover, blood samples from 458 dogs were taken and studied with both Direct Aglutination Test (DAT) and a newly presented dipstick test . All children under 12 were also studied with DAT. In computing the sample size the generalizability for 63 variables with a minimum and maximum probability level of 90% and 97% respectively were taken into account and since the cluster sampling was employed, the Design Effect would be at least 1.56 and for different variables in the first sample it would be at most 4. Results: Only 30 households(9.7%) used piped water supply inside their houses while most of the other families (41%) obtained their water from mobile water tanks. Residual water chlorine was measured to be zero in 88.7% of the samples taken from drinking water of Ashayer. 89 (27.8%) households had lavatories and 22 (7%) households had bathrooms inside their houses. 90.4% of those using raw vegetables washed them only with plain water. Monthly incidence rate for accidents was 230 per 10000. 18.1% of women in reproductive age had a history of abortion. Unwanted pregnancy rate was 38.9%. 47.1% of women with a labor history in past three years had never been visited by any person legally allowed to do so. Women in reproductive age had a poor knowledge about contraceptive methods. The minimum delay for vaccination was 16.9 (SD= 19.26) days regarding the third dose of OPV and the highest delay in vaccination was 46.44 (SD=60.7) days belonging to the third dose of HBV. From all 503 persons above 12 years old, 77 cases had hypertension. Periodontal easy bleeding was observed in 13.7 % and pyorrhea in 19.3%. 10.2 % had aching neck, 18.7% had backache and arthralgia was shown in 13.5%. The unmet need for physician's visit was 64.8%. The frequency of positive cases of leshmaniasis was 3.4% and 3.06% for boys and girls respectively. 28 male and 6 female dogs were positive in DAT test making an overall positive rate of 7.4%. Sensitivity of dipstick test was higher than 80 percent only when golden standard was considered to be DAT ≥ 1 /640. Conclusion: Many of the health indices of Ashayer except for vaccination were suitable. This requires further attemps on the part of govermental and health outhorities. Kale-azar disease can spread to the north of the province as well as the neighboring provinces due to the migration of these tribes. It is predicted that Bilesavar and Parsabad cities will be added to the andemic regions of this disease in coming years. Using dipstick test recently offered by WHO is recommended to be used to screen the infected dogs.
Faride Golfooroshan, Effat Khodaeiani , Shahla Babaei Nejad , Delara Laghosi,
Volume 6, Issue 2 (Summer 2006)
Abstract
Background & Objectives: Diabetes mellitus (DM) is a clinically and genitically heterogeneous group of disorders characterized by abnormally high levels of glucose in blood. The skin is involved both in the effects of acute metabolic changes and in the chronic degenerative compilications of diabetes. Skin lesions are frequently observed in diabetic patients and it is generally stated that about 30% of these patients have cutaneous disorders. The aim of this study was to assess the prevalence of skin lesion in patients with diabetes mellitus referring to dermatology and diabetes clinic of Sina hospital in Tabriz . Methods: This descriptive-analytical study was conducted on diabetic patients with skin lesion who referr e d to diabetic and dermatology clinic of Sina hospital of Tabriz during 2003. Data collecting instrument was a questionnaire which included some variables such as age, sex, job, type of diabetes, its duration, control of blood glucose, receiving regular treatment, type of lesion. The questionnaire was filled out for each patient with skin lesion individally. Skin lesions due to burn were excluded from our study. The data were analyzed by SPSS using Chi-aquare and Fisher test. Results : From a total of 500 patients, 80 patients (16%) had skin lesions. 57.5% of these patients was male and 91.2% had type II DM. Mean age of the patients with skin lesion was 56.86±1.54 years and mean diabetes duration was 10.87±0.82 years. Patients over 50 years had the most skin lesion . The most common type of skin lesion in the diabetic patients were 30 cases of necrotic ulcer (6%) and 22 cases of diabetic dermopathy (4.4%) respectively. Other skin lesions such as infection, sclerodermoid, punched out lesions, neuropathic ulcer, diabetic bulla, dermatitis and lichen planus were not common . 97.5% of diabetic patients with skin lesion had poor control of blood glucose. Twelve percent of the patients had some kind of diabetic foot ulcer (Neuropathic Necrotic, punched out and cellulitis ulcer altogether) of which 21.6% underwent amputation. Conclusion: The results showed that rate of skin lesions in diabetic patients is decreased. compared to the past. This may be due to increase of knowledge and attitude of patients regarding diabetes and its complications.
Fariba Kahnamuie Agdam , Haleh Shahlazadeh , Mina Ataee ,
Volume 14, Issue 4 (winter 2014)
Abstract
Primary Extra nodular non-Hodgkin lymphoma during pregnancy is rare with occurrence rate of 0.8 in 100000 pregnancy. In this report, the case of a 19-year-old woman during week 14 of her intrauterine pregnancy with primary extra nodular non-Hodgkin lymphoma is described. The staging consisted with thyroid open biopsy. After induced abortion the subject underwent chemotherapy with CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisolone) for 6 cycles.
Shahla Mohammad Ganji , Mohammadnaser Molapour , Golamreza Javadi , Eisa Jahanzad,
Volume 16, Issue 3 (autumn 2016)
Abstract
Background & objectives: KAI1 is a tumor suppressor gene and inhibitor of metastasis in a wide range of malignancies. While it is ubiquitously expressed in normal tissues, KAI1 expression subjects to the down regulation in tumors. The present research aims semi-quantitative evaluation of KAI1 mRNA expression in Iranian patients with colorectal cancer (CRC) and correlation between expression levels of KAI1 and stage oftumorigenesis, especially metastasis and invasion of CRC as well as pathologic factors of patients.
Methods: RT-PCR was done by specific primers for KAI1 and β-actin genes on the 80 tumor tissues and 14 normal tissues as fresh samples which obtained from 80 unrelated patients referred to Imam Khomeini Hospital.
Results: According the results, 51.2% and 48.8% of the sample were on and off for KAI1 gene expression, respectively. As a detail, 97.3% of samples in the stage 3 and 4 and 94.5% of metastatic phases samples showed no expression of this gene. Statistical analysis showed that there is a significant difference of the KAI1 expression between four groups of samples; normal, stage 1, 2 and 3 (p<0.05). Also a significant difference was observed between semi-quantitative KAI1 expression and degree of spread to regional lymph nodes (p=0.02) as well as semi-quantitative KAI1 expression and metastasis (p=0.000001).
Conclusion: A significant difference between semi-quantitative expression of KAI1 and degree of spread to regional lymph nodes (p=0.02) and metastasis (p=0.000001) was observed.
Shokouh Chegini, Mina Ramezani, Solmaz Shahla,
Volume 18, Issue 2 (summer 2018)
Abstract
Background & objectives: Artemisia absinthium (known as wormwood) is used as an antihelminthical, antimalarial, antiseptic and anti-inflammatory agent, and is used for treatment of gastric pain in the traditional medicine. In the present study, we evaluated the effects of hydroalcoholic extract of A. absinthium on the ovary tissues and pituitary_gonadal axis of the adult female NMRI mice.
Methods: In this experimental study, intraperitoneally (IP) injections of hydroalcoholic extract of A. absinthium, were performed over 30 days on 50 mice with 50 (first group), 100 (second group), and 150 mg/kg.bw (third group) doses. The sham group was received distilled water and control group received no injection. After 30 days of injections, the animals were dissected, and blood samples were collected by heart aspiration. The levels of LH, FSH, estrogen and progesterone of serum were measured by ELISA method. Seven µm sections of ovary were prepared by a microtome and stained by H&E method. Data were analyzed by One-Way ANOVA and Tukey post- hoc test. The Significance level was set at p<0.05.
Results: Our findings indicated a significant reduction (p<0.05) in the body weight in all experimental groups compared with sham and control groups. In parameters such as: large and small diameters of the ovary , number of primary, secondary, growing, graafian follicles, and corpus luteum, a significant decrease was observed in 100 and 150 mg/kg doses (p<0.05). In all experimental groups, no significant changes were observed in estradiol and progesterone levels. However, FSH and LH showed a significant decrease in 100 and 150 mg/kg doses (p<0.05).
Conclusion: Therefore, it can be concluded that Artemisia absinthium hydroalcohlic extract in high doses has damaging effects on the process of oogenesis, which may be due to α and β Thujoun, Alkaloid and Saponin constituents in this plant.
Seyed Hosseiali Saberi, Behnam Kamalidehghan, Shahla Farshidi , Dr. Seyed Masoud Houshmand, Roshanak Jazayeri,
Volume 20, Issue 2 (summer 2020)
Abstract
Background & objectives: Mucopolysaccharidosis IVA (Morquio syndrome type A) is a lysosomal storage disorder caused by a mutation in the GALNS gene located on chromosome 16q24.3 and is inherited in an autosomal recessive manner. To date, more than 300 different mutations associated with MPS IVA, have been reported. Mutational heterogeneity can lead to difficulties in interpretation of molecular testing results, as novel mutations/variants of unknown significance may be detected relatively frequently. The purpose of this study is to analyze the GALNS mutations in Iranian MPS IVA patients.
Methods: Mutation screening of the GALNS gene was performed using direct sequence analysis on DNA samples from 8 unrelated Iranian MPS IVA patients.
Results: We have identified three novels and four previously reported mutations in 8 Iranian patients. We identified three novel missense mutations including: c.680T>C (p.F227S) in exon 7, c.G949C (p.G317R) and c.956G>C (p.R319T) in exon 9 in three different Iranian MPS IVA patients. Bioinformatics analysis predicted the novel mutations as being disease-causing.
Conclusion: Our findings indicate the molecular heterogeneity of GALNS gene in Iranian patients. We also managed to find three new mutations of MPS IVA in Iranian patients, which are helpful in diagnosis, genetic counseling and prenatal diagnosis in affected families
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