Background & Objectives: Consumption of ω3 fatty acids supplementation inhibits oxidative stress injury, increases activity of antioxidant enzymes and decreases lipid peroxidation in gastric cancer patients. In this study, we examined effects of ω-3 fatty acid intakes on oxidative stress in gastric cancer patients undergoing chemotherapy.

  Methods: This double blind clinical trial study was conducted on 30 adult patients (15 cases and 15 controls) with gastric cancer during chemotherapy in Ardabil city in 2010. Case and control groups were selected by randomized allocation. Three grams ω -3 fatty acid supplementation (1.8 g EPA & 1.2 g DHA in 10 g fish oil) and placebo were given case and control groups for 45 days, respectively. Anthropometric indices (weight, height & BMI) were measured. Blood samples were taken and then biochemical factors including triglycerides, total cholesterol, HDL and LDL cholesterol, MDA, and total antioxidants were evaluated at the beginning, middle and end of the study . The data were analyzed by using Paired sample t-test, Independent sample t-test and repeated measures test.

  Results: MDA, Weight and BMI of omega group after intervention were significantly more than control group at the end of the study (p<0.05). Weight and BMI were decreased but serum MDA was significantly increased in control group during the study (p<0.05). Weight, BMI , and total antioxidants were significantly increased in omega group during day 30-45, (p<0.05). There were no significant differences in other biochemical factors at the end of study.

  Conclusion: The present investigation shows administration of ω3 fatty acid supplements to gastric cancer patients during chemotherapy increases the total antioxidants capacity and prevents the enhancement of oxidative stress.

 Background & Objectives: The intake of antioxidant supplementations can have key role in prevention of oxidative stress in healthy individuals. Pomegranate has antioxidant effects and may play a role in reduction of oxidative stress in healthy males. Therefore, this study examined the effect of pomegranate juice supplementation on oxidative stress in young healthy males.

 Methods : In semi-experimental study, 14 healthy students living in Dormitories of Ardabil University of Medical Sciences were included. Subjects were given one cup of pomegranate juice supplementation per day for two weeks . Fasting blood samples were taken both at the start and the end of 2-week period to measure the antioxidant enzyme activities such as superoxide dismutase , glutathione peroxidase , paraoxonase - 1, aryl esterase , and the values ​​of serum total antioxidant capacity , glutathione, and lipid profiles . Data were analyzed using descriptive and paired t - test s.

 Results: T he level of serum total antioxidant capacity and activities of enzymes such as superoxide dismutase, glutathione peroxidase, arylesterase, and standardized arylesterase activity were significantly increased at the end of two weeks (p<0.05). The serum level of malondialdehyde was significantly decreased after intervention (p<0.05). Changes were not significant, although the serum levels of glutathione and HDL- cholesterol increased and LDL- cholesterol decreased at the end of two weeks period.

 Conclusion: The results of this study showed that the pomegranate juice supplementation had beneficial effects in helping body's antioxidant defense system and reduction of oxidative stress in young healthy males . This study suggests that the pomegranate juice supplementation can be useful against oxidative stress included in dietaries of young healthy males.