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Showing 2 results for Samiee
Rahim Masoumi , Navid Masoumi , Nasrin Fouladi , Elaheh Samiee,
Volume 11, Issue 3 (autumn 2011)
Abstract
Background &Objectives :Hyphema which commonly caused by the blunt trauma, is defined as blood accumulation in the anterior chamber of the eye. It is associated with several complications from which secondary hemorrhage is more important. This study was aimed to determine Tranexamic acid effect on reduction of the secondary hemorrhage in traumatic hyphema. Methods: This study was a randomized controlled trial in 54 patients with traumatic hyphema referred to ophthalmology clinic of Alavi Hospital in Ardabil during 2006-2008. The patients were divided into two groups. Half of the patients received Tranexamic acid and the rest used placebo. After examination of the eyes, the data were analyzed by using Chi-squareand Student-t tests. Results : In this study 79.6% of patients were men and the rest were women. They had 19.8 ± 9.44 years old as mean. The vision for 33.3% of the individuals showed light perception, 29.6% hand motion and 35.2% of them indicated finger count. 1.9% of patients had grade I, 11.1% grade II, 38.9% grade III and 48.1% grade IV hyphema. The patients who received Tranexamic acid did not show secondary hemorrhage but five untreated individuals were undergone bleeding. Conclousion : Tranexamic acid reduced secondary hemorrhage in patients with blunt trauma-related hyphema. We suggest further studies of relationship between intra-ocular pressure and secondary hemorrhage rate.
Mohammad Sofiabadi, Fateme Samiee, Mohammad Hossein Esmaeili,
Volume 23, Issue 2 (summer 2023)
Abstract
Background & objectives: There is a tendency to increase the risk of dementia in patients with periodontitis, but the opposite, the role of Alzheimer's disease on periodontal disease is still unclear, so in this study, the effect of experimental Alzheimer's disease on periodontal inflammatory cells, collagen fibers and neovascularization was investigated in male rats.
Methods: In this experimental study, 16 Wistar male rats (230-250 grams) were randomly divided into 2 groups; control (saline) and streptozotocin 3 mg/kg (bilateral ICV injection, with a volume of 10 μl, in both groups). After 4 weeks of treatment, two groups were tested with the Morris water maze. Then the rats were killed by deep anesthesia and sampling from the papilla around the two central incisor teeth was done. Samples were fixed and the paraffin block was prepared, serial 5-micron slices were made with a microtome. After hematoxylin & eosin staining, the number of inflammatory cells (PMNs, eosinophils, and mast cells), angiogenesis, and fibroblasts were counted using a microscope (400×). Data were analyzed using SPSS 21 software and an independent T-test.
Results: The results showed that Alzheimer's disease causes an increase in periodontal inflammatory cells, collagen fibers and new vessels in the gums of mice, and the difference between these changes between the experimental and control groups was significant in all parameters (p<0.00).
Conclusion: According to these findings, Alzheimer's disease causes or aggravates inflammation and increases the rate of periodontal diseases in rat and may have the same effect in humans.
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