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Showing 3 results for Safarzadeh
Saeed Mashahadi, Shahram Habibzadeh, Gholamreza Hamidkholgh, Amirahmad Arabzadeh, Elham Safarzadeh,
Volume 0, Issue 0 (In Press 2024)
Abstract
Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-COV2) caused more than one million deaths in the first 6 months of the pandemic and caused huge economic and social problems internationally. An effective vaccine is certainly essential to prevent further deaths. One of the vaccines used in the control and prevention of the disease was the Sputnik V vaccine, and in this study, the side effects of the Sputnik V vaccine in vaccinated individuals in Ardabil province were evaluated.
Methods: In this retrospective descriptive cross-sectional study, the side effects observed in individuals vaccinated with the "Sputnik V vaccine" in the first and second doses were examined. Demographic information such as age and gender, history of drug use, general side effects including respiratory, gastrointestinal and neurological side effects and local side effects such as pain, swelling, redness, muscle spasms, as well as the time of onset of side effects and the duration of side effects were recorded for all vaccinated individuals. After collection, the data were analyzed using statistical methods.
Results: Among general complications, body aches were the most common with 65.4% and palpitations were the least common with 1.71%. In terms of respiratory complications, sore throat and burning sensation in the throat were the most common with 8.3% and runny nose was the least common with 3.9%. Among gastrointestinal complications, nausea was the most common with 13.4% and vomiting was the least common with 2.0 %. In terms of local complications, injection site pain was the most common with 50.5% and armpit pain on the same side of the injection was the least common with 3.9%.
Conclusion: Side effects of the Sputnik V vaccine were usually mild to moderate and acceptable and tolerable.
Mahshid Khajavi, Elham Safarzadeh, Faraz Mahdizadeh, Shokofeh Banaei,
Volume 0, Issue 0 (In Press 2024)
Abstract
Background: 5-fluorouracil is one of the chemotherapy drugs that has destructive effects on body tissues such as the heart, liver, kidney, brain and reproductive system in humans and animals. Reproductive dysfunction is considered to be an important side effect of chemotherapy drugs such as 5-fluorouracil (5-FU). This study was designed to assess the effects of Oleuropein (OLE) against 5-FU-induced ovarian toxicity.
Methods: 24 adult female rats (weighing 200-225 g) were randomly divided into 4 groups (N= 6) with a treatment period of 14 days including the control group, 5-FU (100 mg/kg/week, IP), OLE (200 mg/kg/day, IP), 5-FU + OLE group, administrated 5-FU (100 mg/kg/week) with OLE (200 mg/kg/day). After treatment, blood samples were collected for the measurement of female sexual hormones, and ovarian samples were taken for histological assessment.
Results: 5-FU significantly decreased female sexual hormones. Also, it caused tissue damage in the ovary, as 5-FU-administered rats had degenerated follicles and hemorrhage. While the administration of OLE significantly increased the estradiol, and progesterone (p< 0.05) levels and improved ovarian pathological changes.
Conclusion: Oleuropein reduces 5-fluorouracil –induced reproductive toxicity in female rats.
Mohsen Yaghoubi , Lotfali Bolboli , Abbas Naghizadeh , Aydin Valizadeh , Samad Safarzadeh ,
Volume 14, Issue 1 (spring 2014)
Abstract
Background and Objectives : The risk of coronary artery disease increases with increasing of blood pressureboth in hypertensive and normotensive persons on the other hand nutritional factors have asignificant effect on blood pressure. The purpose of this study was to assess theeffect of caffeine on blood pressure in sedentary healthy male during resistance exercise. Methods: In single-blind crossover study , twenty healthy and non-athlete male in the University of Mohaghegh Ardabili randomly selected and stratified according to age and BMI into twogroups: caffeine and placebo. The subjects performed repetitions to exhaustion at 60% of 1RM for any motion of chest press, leg press, squat and lat pulldown, 1 hour after taking caffeine (6 mg/kg body weight) or Placebo (similar dosage of starch). Blood pressure (BP) was measured before and 1 hour after taking caffeine and also immediately after any exercise. Data analysis was conducted using independent and paired t-test. Results : Results indicated that systolic and diastolic BP and mean arterial pressure significantly elevated following caffeine intake at rest, but no significant differences were observed after exercise. Conclusion: These findings indicate that caffeine at this dosage level alters cardiovascular dynamics by augmenting arterial blood pressure in moderately non-athletes male at rest. However, it seems that taking caffeine before resistance exercise does not cause abnormal elevations in blood pressure in sedentary healthy male.
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