---

  Background and objective: Injuries account for 16% of global burden of diseases and causes a great deal of mortality and morbidity. Today, amputation is one of the biggest challenges facing us and may accompany serious functional, psychosocial and personality disorders in communities. Therefore, we decided to assess the causes and types of traumatic amputation in patients referring Ardabil’s Fatemi Educational Hospital from 2005 through 2006.

  Methods and materials: The present study was descriptively & analytically) retrospective in which the data were collected using a questionnaire. Our study population included 218 cases referring Ardabil Fatima educational Hospital for amputation from the beginning of 2005 through the end of 2006.

  Results: In this study, the mean age of injured cases is 28.9±19.1 and men were also injured three times more than women. Most of the cases attended in summer between 8:00 Am -8:00 Pm. The number of cases among city dwellers and residents of rural areas were almost equal and most of the cases (39/6%) were illiterate. Most of the cases were injured outdoors especially in their workplace. The most commonly seen cause of amputation was tools used in farming and husbandry especially mower. Most of the amputations (50/5%) were total and unintentional (99.5%). Most of the injuries were seen in upper extremities (94.5%), hands and especially fingers (97%)�

  conclusion: Based on the obtained results, male workers are at a higher risk. Most of the injuries occurred during the work hours and amputation caused by tools used in farming and husbandry has a high prevalence. This is probably due to the unsafe and old structure of these tools.

---

 
Background & objectives: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by systemic inflammations and is characterized by irreversible airflow limitations. Leptin is a cytokine with pre-inflammatory effect. However, there have been no studies on the effect of conjugated linoleic acid (CLA) on the serum leptin concentration in COPD patients. Therefore, the present study aimed to explore the effect of CLA on the serum leptin level, lung function and quality of life in COPD patients.
Methods: This interventional study was conducted on 90 COPD patients. The patients were randomly divided into two groups (supplement and placebo) with 45 patients per group. After obtaining written consent from the patients and recording their demographic characteristics, the spirometry was performed and COPD assessment test (CAT) score was calculated. Moreover, a fasting blood sample was collected from each of them in order to analyze their serum leptin concentration. After that, the patients in the supplement group were administered with 3.2 g/day of CLA for 6 weeks. The patients in another group received placebo. After the intervention, spirometry, CAT score calculation and blood sampling were repeated for all of the patients and the obtained results were analyzed.
Results: after the intervention, a significant decrease both in the serum leptin level and in CAT score as a quality life marker  was observed in the supplement group (p<0.05). Moreover, the FEV1 levels as a lung function test, increased significantly in the supplement group after the intervention (p<0.05). Although, the difference between the two groups was not significant.
Conclusion: The use of CLA supplement can improve COPD patients’ quality of life through decreasing the serum level of leptin in their blood.
 

---

Background & objectives: Recent evidence suggests that bone morphogenetic proteins (BMPs) are involved in regulating of adipose tissue. This study aimed to evaluate the effect of three resistance training methods on bone morphogenetic protein 2 and lipid profile in obese men.
Methods: In a semi-experimental trial, 44 obese men (23-32 years) were selected and randomly divided into four groups, including control, interval resistance training, traditional resistance training and circuit resistance training. Interval, traditional and circuit resistance training performed with an intensity of 50% of maximum repetition and active rest, 3-time sessions per week for 12 weeks. Serum BMP-2 levels were measured using an ELISA kit. Data were analyzed using paired t-test, one-way analysis of variance and Tukey post hoc test at the p<0.05.
Results: The results showed that interval, traditional and circuit resistance training were associated with a significant decrease in bone morphogenetic protein 2 (BMP-2), LDL, cholesterol and triglyceride concentrations in interval, traditional and circuit resistance training groups, and also a significant increase in HDL concentration in interval and circuit resistance training groups in comparison with   the pretest (p<0.001). BMP-2 levels were significantly lower in the interval resistance training group than in the traditional resistance training group (p<0.001). The HDL and LDL, cholesterol and triglycerides levels in obese men in the interval and circuit resistance training groups were significantly higher and lower than in the interval resistance training group, respectively (p<0.001).
Conclusion: 12 weeks of the interval, circuit and traditional resistance training were associated with decreased BMP-2 and improved lipid profile in obese men, and interval resistance training may be more effective on BMP-2 and lipid profile in obese men.