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Showing 4 results for Roghani
Zahra Kiasalari , Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Mohammad Javad Hasas ,
Volume 14, Issue 3 (Autumn 2014)
Abstract
Background & objectives : Epileptic seizures accompany disturbances in learning, memory, and cognitive skills. With regard to antiepileptic potential of curcumin and its beneficial effect on memory, the effect of its administration on learning and memory in kainate-epileptic rats was investigated. Methods: Forty male rats were divided into sham, positive control ( valproate-treated epileptic), epileptic, and two curcumin-treated epileptic groups. Rat model of epilepsy was induced by unilateral intrahippocampal administration of 4 μg of kainate per rat. Rats received intraperitoneal injection of curcumin (50 and 100 mg/kg) daily for 1 week before surgery. For evaluation of learning and memory, initial (IL) and step-through latencies (STL) were determined using passive avoidance test and alternation behavior percentage was obtained according to Y maze test. Results: Regarding IL, there was no significant difference between the groups. In contrast, STL significantly decreased in curcumin-50-treated epileptic group (p<0.05) (a change from 263.1 to 184.5 s). However, this parameter significantly increased in curcumin-100-treated epileptic group as compared to epileptic group (p<0.01) (a change from 263.1 to 220.3 s). In addition, STL was also significantly higher in valproic acid-treated epileptic group versus epileptic group (p<0.05) (a change from 145.7 to 210.3 s). Alternation percentage was also significantly higher in curcumin-50- and curcumin-100-treated epileptic groups relative to epileptic group (p<0.05) (a change from 60.5 to 77.6 and 80.3%). Conclusion: Curcumin could dose-dependently enhance the consolidation and recall in epileptic animals and could improve spatial memory in such animals.
Zahra Kiasalari, Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Athar Abdolrazaghnezhad,
Volume 16, Issue 1 (spring 2016)
Abstract
Background & objectives: Temporal lobe epilepsy is associated with neuronal apoptosis. Curcumin has antioxidant and anticonvulsant activities, therefore this study was conducted to assess involvement of Bax and Bcl2 in protective effect of curcumin in epileptic rats.
Methods: 28 rats were divided into sham, curcumin-pretreated sham, epileptic (kainate), and curcumin-pretreated epileptic groups. Experimental model of epilepsy was induced by intrahippocampal administration of kainic acid. Rats received curcumin at a dose of 100 mg/kg. Finally, Nissl staining and Bax and Bcl2 immunohistochemistry were conducted on hippocampal sections and data were analyzed using one-way ANOVA and unpaired t-test. The p-value less than 0.05was considered statistically significant.
Results: Induction of epilepsy was followed by a significant seizure and curcumin pretreatment significantly reduced seizure intensity (p<0.01). In addition, there were no significant differences between the groups in Nissl staining of CA3 area neurons. In addition, Bax positive neurons were observed in CA3 area in kainate group and significantly decreased in curcumin pretreated rats (p<0.05). Meanwhile, Bcl2 positive neurons were also moderately observed in kainate group and curcumin pretreatment significantly increased it (p<0.05).
Conclusion: Curcumin pretreatment exhibits anticonvulsant activity in epileptic rats. It also decreases the expression of pro-apoptotic protein Bax and significantly enhances the expression of anti-apoptotic protein Bcl2 and hence could reduce neuronal apoptosis.
َasieh Alizadeh Makvandi , Mohsen Khalili, Mehrdad Roghani, Sara Amiri Moghaddam ,
Volume 19, Issue 4 (winter 2019)
Abstract
Background & objectives: Depression is a common and debilitating brain disorder and a type of psychiatric syndromes. The most common symptoms of this disease are irritability, worthlessness, sleep problems and anxiety disorders. Reserpine is a drug that can cause depression in animals if used at a very low dose. Electroconvulsive therapy (ECT) is one of the most effective non-pharmacological treatments for depression. In this study, the effect of electroconvulsive therapy on male rats depressed by reserpine in behavioral tests and neural counting in the hippocampus and prefrontal cortex areas was investigated.
Methods: In this experimental study, 40 male rats were used and they were divided into four groups of ten: 1-control group, 2- ECT group, 3- Depressed group induced by reserpine (0.2 mg/kg i.p.), 4- Depressed + ECT group. Open field, sucrose preference, forced swimming and elevated plus maze tests were used to evaluate anxiety and depression-related behavioral function. At the end of the tests, histochemical studies were performed with neuronal counting in the hippocampus and prefrontal cortex.
Results: The results of anxiety and depression behavioral tests showed a significant difference between depressed group and depressed+ECT group (p<0.05). Similarly, studies of the tissue degeneration from hippocampal and prefrontal incisions, showed that ECT could significantly decrease cell death in the depressed+ECT group compared to the depressed group (p<0.05).
Conclusion: According to the results, ECT can reduce the anxiety and depression behaviors induced by reserpine injections in depressed animals and can cause neurogenesis in the hippocampus and prefrontal cortex.
Soheila Fakhrian Roghani, Allahyar Arabmomeni,
Volume 23, Issue 4 (Winter 2024)
Abstract
Background: Obesity is a major health problem worldwide. Therefore, the purpose of this study was to determine the effects of l-carnitine supplementation on physical factors related to health and lipid profiles in obese female children with basic gymnastics exercises.
Methods: In this quasi-experimental study, with a pre-test-post-test design and a placebo group, 60 obese children among the girl students of Isfahan with BMI=30.28 kg/m2 were selected purposefully and were divided into 4 groups (Basic gymnastics training, L-carnitine consumption, Combined, and Placebo). The training protocol was implemented for 12 weeks, three times a week, and 45 minutes for each session. Furthermore, the groups of L-carnitine consumption and combined used L-carnitine tablets with a dose of 2 g per day for 12 weeks. To analyze the data, multivariate covariance, and post hoc Tukey tests were used.
Results: A significant increase in Cardio-respiratory endurance, muscular endurance, muscular strength and flexibility was observed in both basic gymnastics training and combined groups (p≤0.001). In addition, a significant decrease in total cholesterol, triglyceride, and LDL and a significant increase in HDL were observed in the basic gymnastics training, and combined groups (p≤0.002). Also, the changes caused by the combined group on all variables were significantly better than other groups.
Conclusions: These findings indicate the beneficial effects of basic gymnastics training along with L-carnitine supplementation on physical factors related to health and lipid profile in obese children. Therefore, the combined use of basic gymnastic exercises and L-carnitine supplementation can be useful to improve these variables.
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