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Showing 11 results for Rezai
Eiraj Sayadrezai, Majid Rostami,
Volume 8, Issue 3 (Autumn 2008)
Abstract
Background & objectives: Warts are common dermatological disorder which are difficult to treat and usually relapse. In this study the efficacy of topical %5 5- fluorouracil was compared with conventional cryotherapy in treatment of plantar Warts. Methods: In a clinical trial study, 50 patients clinically diagnosed as warts were divided in to two groups. 25 patients were treated with topical 5% 5- fluorouracil while the other 25 were treated with cryotherapy. After treatment, patients were followed for 6 months from the viewpoints of treatment complication, efficacy and relapse rate. Results: It was observed that treating period in cryotherapy was short but 5F-U therapy needed longer time. Initially in 5-FU group 52% of patient had good response, 36%moderate response and in 12% no response was observed there is no significant difference in view of sex in this group (p=51%) and in cryotherapy group 60% of patients had good response, 28% moderate response and in 12% no response was observed like wise there was no significant difference in terms of gender (p=0.08). In response to therapy there was no difference between two groups (p=0.09%) after 6 months follow up relapse rate was 18% in cryotherapy patients and only 8%in 5-FU group which wasn't statistically meaningful and no difference was observed between two groups (p=0.27). Conclusion: The results indicated that course of treatment was shorter in cryotherapy than the topical 5- FU but the relapse rate didn't have any difference between two groups. The only significant difference was pain in which 5- FU was painless but cryotherapy was painful.
Khalil Rustami, Hosein Zohouri, Eiraj Sayad Rezaii ,
Volume 8, Issue 4 (Winter 2008)
Abstract
Background and objectives: The most common cause of death in the people (1-44 years old) is trauma and it ranks third as the cause of death in all ages. Road and city accidents with motor vehicles and its effects consist 50% of trauma cases. The mortality rate in traffic accident shows the depth of traffic event, but in any way most of the victims can be saved and we can prevent many of these accidents. The accident is of greater importance in especially developing countries like our country, because in addition to losing a great number of active economic and social power, it causes damage in the corpus of the community, in a way that these accidents cost more than 3% of country in gross productions. Methods: This investigation which is considered as a descriptive study is in order to do an epidemiologic investigation of accidents that have led to death in Ardabil Province from Farvardin 2002 to Farvardin 2003 through collected data from Ardabil’s legal medicine center and was analyzed through SPSS. Results: The analysis of collected data consisted of 272 cases of events, shows that most of them are male (82%) and they are 21-30 years old. The existence of inversed relation ship with educational level and mortality rate was one of the other findings. Also it became clear that most of the vehicles were small vehicles (70.6%) and most of the victims were pedestrians (34%). Accidents rate in road was 63.6% and accidents in the cities 36.4%, and most of them have happened in summer (38.2%). Most of the mortalities took place in the first minutes and at the same place of accident (50%) and mortality cause of most people was multiple traumas (48.5%) and Brain injuries (46.6%). Conclusion: Factors influencing the rate of death in accidents are as followings: male, age (21-30), low education level, summer, and small vehicles. The main causes of death in accidents are multiple trauma and head injuries.
Eiraj Sayadrezai, Esmaeil Farzaneh , Ahad Azamy , Afsaneh Enteshari Mogaddam, Samira Shahbazzadegan, Reza Mehrgany,
Volume 9, Issue 4 (winter 2009)
Abstract
Background and objectives: Suicide is an important problem for social safety and health. This phenomenon is costly for remedy and also is against Islamic values and ethics. Recognizing some risk factors of forecasting after epidemiologic studies on people whom attempted to suicide could prepare and present outlines and proper guides for preventing by health and social planners. This research is purposed on suicide epidemiologic study to obtain full and enough data about deceased people by suicide in Ardebil province. Methods: The subjects of this descriptive, analytic and sectional research were 64 deceased people by suicide from 2003-2008, who were registered in Bualy, Fatemu, Alavi Hospital and Forensic Medicine of Ardabil Province. The Data was gathered by a researcher designed questionnaire and analyzed using SPSS software. Results: The highest rate of suicide belonged to age rank of 15-24 years (43.8 %), which occurred in female (62.5 %), married people (57.8 %) urban society (65.6 %) and patient without past chronic physical illness or psychiatric history and without pre-attempt suicide. Self poisoning by drugs and toxins were the most common used method in this case (90.6 %). Orderly the most common used drugs were Organo-Phosphorate Toxins, Tricyclic Antidepressants and Aluminum Phosphid. Conclusion:This research is indicating various risk factors such as sex, age, marriage status, residing place of society and easy access to drugs and toxins. According to obtained results, it is better or proper to accomplished related education and training of preventation and interference of mental health in second and third decades of life with allocation of much time for females (especially married). We suggest paying more attention to education, preventation, diagnosis and treatment of poisoning especially poisoning by most common drugs and toxins.
Parviz Mohajeri , Babak Izadi , Mansour Rezai , Badie Falahi , Hosna Khademi , Roya Ebrahimi ,
Volume 11, Issue 1 (spring 2011)
Abstract
Background & Objectives: Nowadays, appearance of ESBL producing bacteria is medical problem in the treatment of infections. Uropathogenic Escherichia coli like many other bacteria can produce these types of enzymes. T he assessment of the ESBL production by clinical isolates is not done routinely in laboratories. The aim of this study was to determine the prevalence of ESBL producing E.coli and its antibiotic resistance pattern in Kermanshah. Methods: This cross - sectional study was done on 200 Uropathogenic E. coli strains isolated from people in Kermanshah. Sensitivity of isolates to different antibiotics was determined by disk diffusion test and ESBL production was assessed by DDST method. Results: The E. coli strains showed high susceptibility to imipenem (100%), amikacin (97%), nitrofurantoin (95.5%), gentamicin (85%), cefepime (75%), ceftazidime (74%), ofloxacin (73.5%), ciprofloxacin, ceftriaxone and aztreonam (71%) and cefotaxime (70%) respectively. The highest resistance was seen to ampicillin (77%), carbenicillin (76%), pipracillin (74%) and SXT (62.5% ). Resistance rate to third generation cephalosporins was 63-75%. Fifty seven isolates (27%) were ESBL producers and 47 isolates (87%) produced all four types of ESBL enzymes. Conclusion: There are some similarities and differences in the antibiotic resistance pattern and ESBL production among the isolates in different areas of Iran and other countries. Identification of ESBL producing bacteria and determining its antimicrobial resistance pattern are recommended to effective treatment of infections.
Darioush Mohajeri , Ali Rezaie , Ghafour Mousavi, Mohammad Mazani, Adel Rezaei-Moghadam,
Volume 12, Issue 2 (summer 2012)
Abstract
Background & Objectives: The aim of the present study was to evaluate the protective effects of Crocin on rat high fat diet-induced hepatic steatosis model. Methods: For this purpose, male rats were given either standard diet as control, high fat diet for induction of hepatic steatosis and high fat diet plus Crocin through gavage at different doses (25, 50 and 100 mg kg-1/day) for protection of liver steatosis, at a period of 4 weeks in different experimental groups and compared considering serum lipid profile, serum biomarkers of liver tissue injury, hepatic antioxidant activity and liver histopathological changes. The serum levels of triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein for determination of deleterious metabolic effects, alanine aminotransferase, aspartate aminotransferase for determination of hepatocyte injury, alkaline phosphatase, bilirubin for assessment of biliary function, malondialdehyde and reduced glutathione content for assessment of liver free radical activity, the enzymatic activities of glutathione peroxidase, superoxide dismutase and catalase as indicators of antioxidation in liver tissue, were measured. Finally, the biochemical findings were matched with histopathological verifications. Results: After 4 weeks, high fat diet caused deleterious metabolic effects, including hypertriglyceridemia, hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Crocin treatment significantly reduced elevated markers of liver tissue injury and malondialdehyde , and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the heptoprotective effect of Crocin. Conclusions: Crocin exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions.
Hosein Najafzadeh, Mahmood Khaksari Mahabadi, Sareh Rezaie, Peghah Ardalani,
Volume 13, Issue 1 (spring 2013)
Abstract
Background: Crocus sativus L., commonly known as saffron is used for different purposes such as an antispasmodic and expectorant. Recent studies have demonstrated that saffron extracts have antitumor, radical scavenger, hypolipidemic, anticonvulsant effects and it improves activity on learning and memory. The aim of the present study was to assess the effect ofaqueous saffron extracton weight, length, macroscopic and microscopic skeletal malformation in fetuses of rats. Methods: Study was carried on 3 groups of female Wistar rats. Group1 was kept as control and received normal saline with equal volume of extract Group 2 received saffron extract with 80mg/kg-IP on 10th and 11th day of gestation Group 3 received saffron extract with 200mg/kg-IP on 10th and 11th day of gestation. Rats were dissected on day 20 of gestation, embryos harvested by cesarean section. The living status and weight and length of fetuses were detected. After examination for determination of gross malformations, fetuses were placed in alcohol and stained by Alizarin red-Alcian blue method then evaluation was carried by stereomicroscope. Results: Saffron extract at dose of 80 mg/kg significantly increased the weights and body-lengths of fetuses in compare with saline and extract at dose 200 mg/kg. Macroscopic and Microscopic studies did not show any skeletal abnormalities by two above doses of saffron. Conclusion: The results show short time administration of saffron aqueous extract does not cause malformation on skeletal system.
Abolfazl Mozafari , Syiamak Mohebi, Mohsen Rezaie, Zahra Afrakhteh ,
Volume 14, Issue 2 (summer 2014)
Abstract
Background & objectives : O bstructive sleep apnea is a preventable and prevalent major health hazard with serious health consequences including excessive daytime sleepiness, cognitive disturbances, depression, cardiovascular diseases and hypertension. Obstructive sleep apnea is a disorder affecting 2 to 4% of the adult population. The continuous positive airway pressur e (CPAP) i s the most efficacious therapy and is often the first option for these patients. The pressure titration during laboratory polysomnography is required for treatment by CPAP. Methods: The patients with obstructive sleep apnea requiring continuous positive airway pressure treatment were selected . CPAP titration was done according to American Academy of Sleep Medicine protocol. Comparison among continuous positive airway pressure with polysomnographic parameters was performed and analyzed with Pearson correlation coefficient. For analysis of qualitative parameters, we used chi-square and then checked with SPSS version 18 software. Results: From 125 patients with obstructive sleep apnea, there were 112 cases with inclusion criteria. Mean age of participants was 55.07 ± 12, male frequency was 59.2%, apnea hypopnea index was 43.62 and mean continuous positive airway pressure was 12.50 . There was significant relationship among the pressure of continuous positive airway pressure with apnea hypopnea index (P=0.028), arousal index (P=0.011), body mass index (P=0.041) and O2 desaturation index (P=0.022), although age was not significantly related. Conclusion: In accordance to this data, we found out a prediction equation for optimal CPAP in our patients
Tayebeh Mohammadi, Mahmood Khaksary Mahabadi , Hosein Najaf-Zadevarzi , Zahra , Rezai ,
Volume 16, Issue 2 (summer 2016)
Abstract
Background & objectives: Cyclophosphamide is one of the common drugs used for cancer treatment. Cyclophosphamide affects the placenta and it is teratogenic in pregnant women. The purpose of this study was to evaluate the protective effects of Mesna and Galbanum essential oil concurrent administration against cyclophosphamide toxicity in rat placenta tissue.
Methods: 22 pregnant female rats were randomly divided into 3 groups: (1) control (normal saline, n=7 rats), (2) cyclophosphamide (15mg/kg, n=7 rats), (3) cyclophosphamide (15mg/kg), Mesna (100mg/kg) and Galbanum (200mg/kg, n=8 rats). Medications were administered intraperitoneally on the 13th day of pregnancy. Then, rats were sacrificed on the 20th day of pregnancy. The placenta was separated and fixed after macroscopic evaluation. 5 µm tissue sections were prepared, stained and studied by light microscopy.
Results: Cyclophosphamide reduced the placental weight, thickness and the length of the small and large diameters. Histologically, it reduced the thickness of the labyrinth and basal layers, caused necrosis and congestion in these layers, reduced giant cells numbers and caused their nuclear shrinkage (p<0.05). Mesna and Galbanum oil had no effect on placental morphometry rather than cyclophosphamide (p>0.05) but histologically it could increase the labyrinth and basal layers thickness and also the giant cells numbers (p<0.05). It could also prevent nuclear shrinkage, giant cells and spongiotrophoblasts necrosis in the basal layer and reduce congestion in the labyrinth layer (p<0.05).
Conclusion: Mesna and Galbanum oil preserved the placenta of pregnant rat against toxic effects of cyclophosphamide probably by its antioxidant features and free radicals deletion.
Ms Shadi Sabetghadam, Afsaneh Keramat, Mina Malary, Sedighe Rezaie Chamani,
Volume 19, Issue 3 (atumn 2019)
Abstract
Introduction & objectives: Vaginismus is an uncontrolled contraction of the outer third muscle of the vagina that prevents intercourse. Based on the DSM-V-TR system, this disorder is associated with dyspareunia and "Genito-pelvic pain/penetration disorder". The purpose of this overview was to summarize population-based studies that reported the prevalence of vaginismus in the general population and to discover the discrepancies between studies.
Methods: This systematic review study was conducted on published articles on the prevalence of vaginismus in the world and in English. In selecting the articles, the keywords including Vaginismus, Prevalence, Incidence, Sexual Dysfunction, Genito-Pelvic Pain, Penetration Disorder with all possible combinations were systematically searched in the google scholar, science direct, PubMed, Cochrane databases. No search time limit was set to retrieve all relevant articles published by September 21, 2018.
Results: Of the 10 studies, 4 articles reported prevalence of vaginismus in the general population. In selected studies, the incidence of vaginismus in the general population of women was reported 0.4% to 8%.
Conclusion: Different prevalence rates have been reported in different studies for vaginismus. In this review study, it was not possible to Meta-analyze and determines the overall prevalence due to the heterogeneity of the prevalence reports and different study methods.
Sadaf Khaki, Nastaran Hadizadeh, Leila Rezaie Shirmard ,
Volume 22, Issue 4 (Winter 2023)
Abstract
Background & objectives: Due to the existence of various issues and limitations associated with traditional buccal drug delivery systems such as the disability to consume food whilst using topical drugs in the mouth cavity, unpredictable drug release profile, undesirable taste, low patient adherence to therapy, and accelerated drug removal with saliva, these conventional methods are now rapidly becoming replaced with oral thin films as more precise and novel oral drug delivery platforms. The current study aims to discuss the design and characterization of betamethasone-loaded oral thin films with the aim of improved drug delivery in mouth cavity diseases.
Methods: In this study, oral thin films with and without betamethasone were fabricated through the solvent casting method as a common, fast, and affordable technique prior to being evaluated for different physiochemical characteristics including weight, width, surface pH, disintegration period in vitro conditions, and swelling rates as well as drug release profiles at different intervals.
Results: Obtained oral films were demonstrated to possess adequate homogeneity, flexibility, and mechanical resistance. Accordingly, the average surface pH for films without and with betamethasone was equal to 6.75 and 6.66, respectively, which are in notable compatibility with the neutral pH of the oral cavity. Betamethasone-loaded films’ disintegration duration appeared to be superior to that of films without betamethasone and was in close correlation with their higher swelling rates. Further experiments revealed 25-30% drug release in the initial 20 minutes, followed by more than 90% betamethasone release in 360 minutes in a sustained manner.
Conclusion: These results are indicative of betamethasone oral films’ satisfactory physiochemical properties and potential applicability as a sufficient oral drug delivery platform in mouth cavity diseases such as oral lichen planus or recurrent mouth sores. By sticking to the mouth mucosa, these films can significantly reduce drug removal with saliva and thus ameliorate sufficient delivery of therapeutic agents to specific mouth lesions. Moreover, they can alleviate some of the issues and limitations of traditional topical oral drug delivery and improve treatment or control of disease symptoms.
Sara Zolfalipormaleki, Hossein Gamari Kivi , Ali Rezai Sharif ,
Volume 23, Issue 3 (Autumn 2023)
Abstract
Background: Given the high prevalence of obesity and overweight and the detrimental impact on the mental health of affected people, the objective of this study is to examine the effectiveness of narrative therapy on social physique anxiety in obese and overweight women.
Methods: The current research was a semi-experimental type, with a pre-test, post-test design with a control group. The study population for this research consisted of all obese and overweight women in Tabriz city in 2023. 30 women were selected by the available sampling method and were randomly divided into two groups: the experimental group and the control group. The experimental group received narrative treatment in 8 sessions of 90 minutes, while the control group did not receive any treatment and was placed on the waiting list. At the end of the treatment period, a post-test was performed in both groups. The Social Physique Anxiety Scale by Hart et al. (1989) was used as the measurement tool. The collected data were analyzed using descriptive statistics (mean and standard deviation) and inferential statistics (covariance test with repeated measures) by SPSS-24 software.
Results: In the pre-test, the mean and standard deviation of social physique anxiety in the experimental group were 44.33±2.289, while in the control group, it was 43.67±3.063. In the post-test stage, the values for social physique anxiety in the experimental group were 36.33±3.117, while in the control group, it was 43.80±3.385. The results indicated the effectiveness of narrative therapy (p<0.001). In the follow-up stages, it was found that the effects of narrative therapy are lasting (p<0.001).
Conclusion: According to the results, it can be concluded that narrative can be an effective method for reducing social physique anxiety in obese and overweight women.
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