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Showing 4 results for Rezagholizadeh
Yavar Mahmoodzadeh , Mohammad Mazani, Lotfollah Rezagholizadeh, Aliasghar Abbaspour, Eslam Zabihi, Pirooz Pourmohammad,
Volume 16, Issue 4 (winter 2016)
Abstract
Background & objectives: Some herbs contain compounds with antioxidant activity and can be used to protect or cure damages caused by chemical toxins. The aim of this study was to evaluate the effects of carbon tetrachloride (CCl4) on total antioxidants in various tissues and Tanacetum parthenium impacts on reducing devastating effects of carbon tetrachloride.
Methods: A total of 42 male Wistar rats were divided into seven groups of six animals in each group: normal control, damaged control, three groups that treated with 40, 80, and 120 mg/kg of Tanacetum parthenium extract 14 days before CCl4 injection and two groups served as post-treatment groups that received 80 and 120 mg/kg extract 2, 6, 24, and 48 h after CCl4 injection. At the end of study the liver, kidney, testis, and heart were removed and then homogenized and then the antioxidant activity of the tissues assessed using FRAP method. Results were analyzed by one-way ANOVA test.
Results: The results showed that the injection of carbon tetrachloride significantly decreasestotal antioxidant in both liver (p<0.001) and kidney (p<0.05) tissues. Administration of extract significantly (p<0.05) increased the total antioxidant of liver and kidney.
Conclusion: Protective effect of Feverfew against CCl4 induced damages is more effective in liver and kidney than testis and heart..
Masoud Ojarudi, Mohammad Mazani, Reza Hajihosseini, Alireza Moradi, Lotfollah Rezagholizadeh,
Volume 18, Issue 4 (winter 2018)
Abstract
Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- intoxicated rats.
Methods: In this experimental study, forty-two male Wistar rats were divided into 7 groups (n=6). Three control groups including normal control, combined extract control and damaged control were designated that received distilled water, a mixture of cinnamon and ginger extracts and distilled water respectively for 14 days.
Other 4 groups were pre-treatment groups which were treated with cinnamon (50 mg/kg/d), ginger (250 mg/kg/d), cinnamon + ginger (25+125 mg/kg/d) and silymarin (100 mg/kg/d) respectively for 14 days before being damaged by intraperitoneal injection of CCl4 (1 ml/kg, 1:1 in olive oil). Fifty - two hours after CCl4 injection, blood sampling was performed and biochemical parameters were measured in serum of rats.
Results: The results of this study showed that the injection of CCl4 significantly increased the ALT and AST enzymes activity ,cholesterol, triglyceride, and LDL levels and decreased the blood albumin and HDL levels in damaged rats compared to the normal control group (p<0.001). However, pre-treatment with the cinnamon and ginger extracts, especially combination of extracts significantly improved these values compared to the CCl4 damage group (p<0.001).
Conclusion: The results suggest that simultaneous use of cinnamon and ginger extracts has more significant protective effects against CCl4-induced hepatotoxicity.
Hamed Fouladi, Lotfollah Rezagholizadeh, Masoud Ojarudi, Amir Khalafi, Mohammad Mazani, Sina • mahdavifard,
Volume 20, Issue 3 (autumn 2020)
Abstract
Background & objectives: The liver is one of the most important organs in the body and plays an essential role in the metabolism of drugs and toxins. Therefore, any damage to the liver can disrupt its function and cause various diseases. On the other hand, due to the increasing use of the medicinal herbs, in this study, the effects of hepatic protection of aqueous extracts of Humulus lupulus on liver damage induced by carbon tetrachloride in rats were investigated.
Methods: In this experimental study, 36 male Wistar rats were divided into 6 groups (n=6). Group 1 (normal control) and Group 2 (control CCl4): administered with distilled water orally for 14 days. Groups 3, 4, and 5 received 50, 100, and 200 mg/kg of Humulus lupulus extract for 14 days respectively. Group 6: administered with silymarin (as standard drug) 100 mg/kg orally for 14 days. All of the groups except group 1 received 1 ml CCl4 (1:1 v/v dissolved in olive oil) on 14th day. All animals were sacrificed and blood samples were collected to determine the biochemical parameters.
Results: Pretreatment with a Humulus lupulus extract significantly reduced the serum levels of ALT, AST, ALP, TG, and increased the serum HDL levels, but did not have a significant effect on GGT and LDL levels.
Conclusion: The results of this study showed that the Humulus lupulus extract can protect the liver from damage caused by carbon tetrachloride and have beneficial effects on lipid profile.
Hamid Vasfi, Hamid Mohebbi, Marefat Siahkouhian, Lotfollah Rezagholizadeh, Abuzar Jorbonian,
Volume 24, Issue 1 (Spring 2024)
Abstract
Background: Weight gain and obesity are the global health problem. Time-restricted feeding is a relatively new method of weight loss with many metabolic and anthropometric benefits. Low-intensity aerobic exercise also has beneficial effects on weight loss and metabolic factors; However, the combined effect of TRF and low-intensity aerobic exercise on metabolic and anthropometric factors in healthy overweight middle-aged men has rarely been investigated. The present research has investigated this purpose.
Methods: Among 55 volunteers, 27 healthy middle-aged men in the age (35 to 55) with overweight (25 The groups included: 1-TRF18:6 & EX 2-TRF 16:8 & EX 2-TRF 14:10 & EX. Three groups performed TRF protocols with different feeding times (6, 8 and 10 hours of free feeding) and fasting in the remaining 24 hours, and the same low -intensity aerobic exercise (55-65% of maximum heart rate). The interventions continued for 12 weeks. Blood and body composition tests were measured before and after the intervention. Daily food intake was measured before the intervention and during 12 weeks. Finally, all the data were analyzed.Analysis of variance with repeated measures was used for analysis. P values less than 0.05 were considered as a significant criterion in all statistical tests.
Results: The combination of TRF and exercise decreased glucose and insulin resistance in all groups. Cholesterol and LDL decreased in the 6-h and 8-h TRF groups. HDL reduction was significant only in the 8-h TRF group. Weight and BMI were reduced in the 6-h and 8-h TRF groups. The percentage of fat reduced in the 6-h group. There was no significant difference between the groups for any of the variables. The average energy received in 12 weeks was not significantly different in any group; however the 6-h model caused a greater decrease in the average energy received during 12 weeks than in the other two groups.
Conclusion: The 6-h TRF model along with light aerobic exercise is suggested as the most reliable method to improve the metabolic and anthropometric profile in overweight middle-aged men.
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