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  Background & Objectives: Lipoprotein [LP(a)] is formed by assembly of LDL particles and carbohydrate rich protein, apolipoprotein(a). LP(a) is elevated in patients with proteinuria or nephrotic syndrome, but it is still controversial whether this is due to hypoalbuminemia or proteinuria.

  Methods: We studied a group of 71 children suffering from nephrotic syndrome in the absence of renal failure. The levels of serum albumin, LP (a), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C) ,high density, lipoprotein- cholesterol (HDL- C), APOAI and APOB were measured by standard methods. The results were compared with those obtained from 75 age and sex matched normal children as control group. The concentrations of creatinin and protein in random urine samples obtained from children and the protein/creatinin ratio were calculated. The Relationship between measured parameters and/or serum albumin and proteinuria was evaluated.

  Results: Compared to the control group the serum levels of total cholesterol, triglycerides, LDL-C, LP (a), APOB and APOAI increated (p<0.05 in all cases), but no marked differences were observed in levels of HDL-C in case group. The levels of serum albumin in patient group were significantly lower than that of control (p<0.05). Serum levels of lipids and lipoproteins including APOAI and APOB were more correlated with plasma albumin level than with protein/creatinin ratio in the patient group.

  Conclusion: The results indicated that in children nephrotic syndrome with on renal failure, the increase of serum levels of LP (a) is mainly related to hypoalbuminemia that stimulates liver synthesis of APOB and is not related to the degree of proteinuria. It was concluded that determination of APOB is the best marker of hyperlipidemia in nephrotic syndrome and normal serum albumin levels seem to be a factor that may determine the of treatment efficacy of hyperlipidemia in nephrotic syndrome.

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 Background & Objectives:�Lipid peroxidation has recently attracted considerable attention. It has been linked to carcinogenesis, aging and variety of other diseases including atherosclerosis. Atherogenesis involves the complicated interaction between cells of the arterial wall and lipoproteins (mainly oxidized LDL). The aim of this study was to investigate the relationship between serum malodialdehyde (MDA), the important indicator of lipid peroxidation and alteration in serum lipids and lipoproteins concentrations in male patients with coronary artery disease (CAD).

  Methods: The subjects of this study were 51 male patients under 55 with angiographically comfirmed CAD admitted to Shahid Madani Hospital and 60 age and sex matched apparently healthy individuals as the control group. The serum level of MDA was measured by colorimetric method using thiobarbituric acid reaction and lipid and lipoproteins concentrations were determined by standard enzymatic methods.

  Results: Significant elevation in the level of MDA was noticed compared to the controls (P=0.03) . Serum concentrations of cholesterol, triglyceride, LDL-C and LDL - C /HDL - C ratio in cases were higher than those of the controls (P=0.03) . There was a positive and significant relationship between serum MDA and biochemical risk factors including Triglyceride, Cholesterol, LDL-C and LDL - C/HDL - C ratio (p=0.03). The correlation between serum MDA and serum HDL-C was negative and meaningful (P=0.03) . No relationship was observed between serum MDA with BMI and age in cases.

Conclusion: Simultaneous control and monitoring of both dyslipoproteinemia and lipid peroxidation may be of equal importance in prevention of occurrence and progression of CAD.