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Showing 3 results for Piri
Mohammad Yousef Alikhani , Masoud Khorasani , Hadi Piri Dogahe, Mahdi Shirzad Siboni,
Volume 11, Issue 2 (summer 2011)
Abstract
Background & Objectives: E. coli is an opportunistic and pathogenic bacterium in human. It is a fecal contamination indicator of the water. The aim of this study is to investigate the efficiency of ultra violet radiation in disinfection of E. coli in aquatic environments in a batch system. Methods: At first, reactor was designed and made. The effects of pH, exposure time and initial inoculum were studied. Kinetic parameters were obtained by application of zero, first and second - order equations . Results: The result showed that removal efficiency decreased with increase of initial inoculumand the kinetics of disinfection was described by first-order model. The result also showed that removal efficiency augmented with increasing exposure time and pH . Conclusion: The results of this study shows that ultra violet radiation can be used as an effective disinfection method for E. coli in aquatic environments.
Ali Niapour, Zahra Taghipour, Sahar Kiani, Fereshteh Karamali, Nazila Niapour, Mohammad Mehdi Mir Hosseini, Mohammad Reza Piri, Hosein Salehi, Noruz Najafzadeh, Mohammad Hosein Nasr-Esfahani ,
Volume 13, Issue 4 (Winter 2013)
Abstract
Objective: Spinal cord injury (SCI) has become an especially challenging target in experimental neuroscience. Approach into the spinal cord is the interface among all different types of spinal cord injury modeling. The lower thoracic spinal cord has generated special interest due to the lower limbs’ spinal pattern generator position and presence of relative scales for behavioral assessment. However, a clear method with which to approach the thoracic spinal cord has yet to be determined. Methods : A total of 20 animals were subjected to this study. Following induction of anesthesia, the 10th thoracic vertebra were positioned, and muscles were retracted. Using the high speed rotary, the vertebral lamina were carefully thinned. As a final point, the reduced lamina was meticulously removed away to expose underlying spinal cord. Loco motor behavioral test (BBB) was implemented before and after surgery procedure. Results: This manuscript has presented the stepwise method to expose rat thoracic spinal cord. Whole procedure took less than an hour. Animals acquired complete BBB loco motor rating score before and after surgery indicating the safety of procedure. Conclusion: This article introduces simple and practical approach for the rat lower thoracic spine. The anatomical orientation, anesthesia , postoperative management , and common problems are discussed .
Ensieh Ahmadpour, Maghsoud Piri, Mohammad Ali Azarbijani,
Volume 21, Issue 4 (winter 2022)
Abstract
Background & objective: Alzheimer's disease (AD) is the most common cause of dementia among the elderly, threatening their quality of life. On the other hand, regular exercise is associated with improved brain health and cognitive function. However, the mechanisms of these benefits have not yet been fully elucidated. Therefore, the aim of this study was to investigate the effect of 4 weeks of moderate intensity interval aerobic training on cognitive function and expression level of PGC1α and VEGF genes in the hippocampus of old rats with AD.
Methods: For this purpose, 20-month-old male Wistar rats were divided into three groups of AD (n=8), AD+exercise training (n=8) and control (n=8). Intra-hippocampal injection of Aβ42 was used to induce AD. The animals in the exercise group performed moderate-intensity interval aerobic exercise for 4 weeks, 5 days a week. To assess spatial learning and memory, the animals underwent the Morris water maze test 48 hours following the last training session. Then, the animals were killed and hippocampal tissue was extracted. Real time-PCR method was used to measure gene expression. Statistical analysis was performed using one-way analysis of variance and Pearson correlation coefficient at the significance level of p£0.05.
Results: The results showed that Aβ42 injection impaired spatial learning and memory function and reduced the expression level of PGC1α and VEGF genes in hippocampal tissue (p£0.05). Aerobic exercise improved spatial learning and memory function and increased PGC1α and VEGF genes expression (p£0.01). Also, a significant positive relationship was observed between the PGC1α and VEGF gene expression levels in the hippocampus (r= 0.859, p≤0.01). In addition, there was a significant inverse relationship between PGC1α and VEGF genes expression and the mean time spent to find the platform (r= -0.9, p£0.01 and r= -0.750, p£0.01, respectively), and a significant positive relationship with the time spent in the target quadrant (r= -0.794, p£0.01 and r= -0.632, p£0.01, respectively).
Conclusion: In general, aerobic training improves spatial learning and memory performance in old animals with AD; up-regulation of the exercise-induced PGC1α/VEGF pathway in the brain, at least in part, appears to be involved in this adaptation.
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